Jochen Weile

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Frederick P (Fritz) RothUniversity of Pittsburgh School of Medicine, Department of Computational & Systems BiologyVerified email at pitt.edu
Atina CotéUniversity of TorontoVerified email at utoronto.ca
Yingzhou WuUniversity of TorontoVerified email at mail.utoronto.ca
Douglas M FowlerUniversity of WashingtonVerified email at uw.edu
Patrick AloyICREA Research Professor at the Institute for Research in BiomedicineVerified email at irbbarcelona.org
Alan F RubinWalter and Eliza Hall Institute of Medical Research Verified email at wehi.edu.au
Anil WipatProfessor of Bioinformatics Newcastle UniversityVerified email at ncl.ac.uk
Marc VidalProfessor of Genetics, Harvard Medical SchoolVerified email at dfci.harvard.edu
Carles PonsInstitute for Research in BiomedicineVerified email at irbbarcelona.org
Jan BaumbachInstitute for Computational Systems Biology, University of HamburgVerified email at cosy.bio
Simon CockellSenior Lecturer, School of Biomedical, Nutritional and Sports Sciences, Newcastle UniversityVerified email at newcastle.ac.uk
Phillip LordLecturer in Computing Science, Newcastle UniversityVerified email at newcastle.ac.uk
Darren WilkinsonProfessor of Statistics, Durham University, U.K.Verified email at durham.ac.uk
Murat TasanRsearch Fellow, University of TorontoVerified email at utoronto.ca
Fan YangPathology, Stanford UniveristyVerified email at stanford.edu
Matthew PocockComputing Science, Newcastle UniversityVerified email at ncl.ac.uk
Gary BaderProfessor of Molecular Genetics and Computer Science, The Donnelly Centre, University of TorontoVerified email at utoronto.ca
George S KaragiannisDepartment of Microbiology & Immunology, Albert Einstein College of MedicineVerified email at einsteinmed.org
Artem LysenkoRIKENVerified email at postman.riken.jp
Matthew M. HindlePostdoctoral Researcher, University of EdinburghVerified email at ed.ac.uk

Jochen Weile

University of Toronto

Verified email at mail.utoronto.ca

Deep Mutational Scanning Protein-protein interaction Systems biology Computational biology


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A reference map of the human binary protein interactome K Luck, DK Kim, L Lambourne, K Spirohn, BE Begg, W Bian, R Brignall, ... Nature 580 (7803), 402-408, 2020	1055	2020
Widespread macromolecular interaction perturbations in human genetic disorders N Sahni, S Yi, M Taipale, JIF Bass, J Coulombe-Huntington, F Yang, ... Cell 161 (3), 647-660, 2015	595	2015
MaveDB: an open-source platform to distribute and interpret data from multiplexed assays of variant effect D Esposito, J Weile, J Shendure, LM Starita, AT Papenfuss, FP Roth, ... Genome biology 20, 1-11, 2019	217	2019
A framework for exhaustively mapping functional missense variants J Weile, S Sun, AG Cote, J Knapp, M Verby, JC Mellor, Y Wu, C Pons, ... Molecular systems biology 13 (12), 957, 2017	197	2017
Multiplexed assays of variant effects contribute to a growing genotype–phenotype atlas J Weile, FP Roth Human genetics 137 (9), 665-678, 2018	141	2018
Pooled‐matrix protein interaction screens using Barcode Fusion Genetics N Yachie, E Petsalaki, JC Mellor, J Weile, Y Jacob, M Verby, SB Ozturk, ... Molecular systems biology 12 (4), 863, 2016	134	2016
Improved pathogenicity prediction for rare human missense variants Y Wu, H Liu, R Li, S Sun, J Weile, FP Roth The American Journal of Human Genetics 108 (10), 1891-1906, 2021	114	2021
Integrative pathway dissection of molecular mechanisms of moxLDL-induced vascular smooth muscle phenotype transformation GS Karagiannis, J Weile, GD Bader, J Minta BMC cardiovascular disorders 13, 1-19, 2013	78	2013
A proactive genotype-to-patient-phenotype map for cystathionine beta-synthase S Sun, J Weile, M Verby, Y Wu, Y Wang, AG Cote, I Fotiadou, ... Genome medicine 12, 1-18, 2020	63	2020
KeyPathwayMiner: detecting case-specific biological pathways using expression data N Alcaraz, H Kücük, J Weile, A Wipat, J Baumbach Internet Mathematics 7 (4), 299-313, 2011	60	2011
Systematic analysis of bypass suppression of essential genes J Van Leeuwen, C Pons, G Tan, ZY Wang, J Hou, J Weile, M Gebbia, ... Molecular systems biology 16 (9), 1-24, 2020	51	2020
Shifting landscapes of human MTHFR missense-variant effects J Weile, N Kishore, S Sun, R Maaieh, M Verby, R Li, I Fotiadou, ... The American Journal of Human Genetics 108 (7), 1283-1300, 2021	49	2021
An integrated dataset for in silico drug discovery SJ Cockell, J Weile, P Lord, C Wipat, D Andriychenko, M Pocock, ... Journal of integrative bioinformatics 7 (3), 15-27, 2010	49	2010
A comprehensive map of human glucokinase variant activity S Gersing, M Cagiada, M Gebbia, AP Gjesing, AG Coté, G Seesankar, ... Genome Biology 24 (1), 97, 2023	36	2023
Mapping DNA damage‐dependent genetic interactions in yeast via party mating and barcode fusion genetics JJ Díaz‐Mejía, A Celaj, JC Mellor, A Coté, A Balint, B Ho, P Bansal, ... Molecular Systems Biology 14 (5), e7985, 2018	31	2018
MaveRegistry: a collaboration platform for multiplexed assays of variant effect D Kuang, J Weile, N Kishore, M Nguyen, AF Rubin, S Fields, DM Fowler, ... Bioinformatics 37 (19), 3382-3383, 2021	24	2021
A web application and service for imputing and visualizing missense variant effect maps Y Wu, J Weile, AG Cote, S Sun, J Knapp, M Verby, FP Roth Bioinformatics 35 (17), 3191-3193, 2019	20	2019
Bayesian integration of networks without gold standards J Weile, K James, J Hallinan, SJ Cockell, P Lord, A Wipat, D Wilkinson Bioinformatics 28 (11), 1495-1500, 2012	18	2012
Assessing predictions of fitness effects of missense mutations in SUMO‐conjugating enzyme UBE2I J Zhang, LN Kinch, Q Cong, J Weile, S Sun, AG Cote, FP Roth, NV Grishin Human mutation 38 (9), 1051-1063, 2017	17	2017
CoryneCenter–An online resource for the integrated analysis of corynebacterial genome and transcriptome data H Neuweger, J Baumbach, S Albaum, T Bekel, M Dondrup, AT Hüser, ... BMC systems biology 1, 1-12, 2007	15	2007

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