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Nicholas R. Larson
Nicholas R. Larson
Verified email at biogen.com
Title
Cited by
Cited by
Year
Comparison of polysorbate 80 hydrolysis and oxidation on the aggregation of a monoclonal antibody
NR Larson, Y Wei, I Prajapati, A Chakraborty, B Peters, C Kalonia, ...
Journal of Pharmaceutical Sciences 109 (1), 633-639, 2020
702020
Glatiramer acetate persists at the injection site and draining lymph nodes via electrostatically-induced aggregation
JY Song, NR Larson, S Thati, I Torres-Vazquez, N Martinez-Rivera, ...
Journal of controlled release 293, 36-47, 2019
292019
Molecular trajectories provide signatures of protein clustering and crowding at the oil/water interface
AC McUmber, NR Larson, TW Randolph, DK Schwartz
Langmuir 31 (21), 5882-5890, 2015
222015
Improved fluorescence methods for high-throughput protein formulation screening
Y Wei, NR Larson, SK Angalakurthi, C Russell Middaugh
SLAS Technology: Translating Life Sciences Innovation 23 (6), 516-528, 2018
212018
Soluble antigen arrays for selective desensitization of insulin-reactive B cells
MA Leon, SM Wemlinger, NR Larson, JK Ruffalo, JO Sestak, ...
Molecular pharmaceutics 16 (4), 1563-1572, 2019
202019
Optimization of RG1-VLP vaccine performance in mice with novel TLR4 agonists
A Zacharia, E Harberts, SM Valencia, B Myers, C Sanders, A Jain, ...
Vaccine 39 (2), 292-302, 2021
172021
pH-dependent phase behavior and stability of cationic lipid–mRNA nanoparticles
NR Larson, G Hu, Y Wei, AD Tuesca, ML Forrest, CR Middaugh
Journal of Pharmaceutical Sciences 111 (3), 690-698, 2022
162022
Label-free, direct measurement of protein concentrations in turbid solutions with a UV–visible integrating cavity absorbance spectrometer
NR Larson, Y Wei, CR Middaugh
Analytical chemistry 90 (8), 4982-4986, 2018
152018
Cis/trans isomerization of unsaturated fatty acids in polysorbate 80 during light exposure of a monoclonal antibody–containing formulation
I Prajapati, BH Peters, NR Larson, Y Wei, S Choudhary, C Kalonia, ...
Journal of Pharmaceutical Sciences 109 (1), 603-613, 2020
142020
Effect of 2 emulsion-based adjuvants on the structure and thermal stability of staphylococcus aureus alpha-toxin
Y Wei, J Xiong, NR Larson, V Iyer, G Sanyal, SB Joshi, DB Volkin, ...
Journal of pharmaceutical sciences 107 (9), 2325-2334, 2018
122018
Effects of glycan structure on the stability and receptor binding of an IgG4-Fc
H Kang, NR Larson, DR White, CR Middaugh, T Tolbert, C Schöneich
Journal of Pharmaceutical Sciences 109 (1), 677-689, 2020
92020
ACUVRA: Anion-Exchange Chromatography UV-Ratio Analysis—A QC-Friendly Method for Monitoring Adeno-Associated Virus Empty Capsid Content To Support Process Development and GMP …
R Frenkel, D Tribby, B Boumajny, N Larson, M Sampson, C Barney, ...
The AAPS Journal 25 (1), 3, 2022
42022
Synthetic Cationic Autoantigen Mimics Glatiramer Acetate Persistence at the Site of Injection and Is Efficacious Against Experimental Autoimmune Encephalomyelitis
JY Song, JD Griffin, NR Larson, MA Christopher, CR Middaugh, ...
Frontiers in Immunology 11, 603029, 2021
32021
Rapid high-resolution size distribution protocol for adeno-associated virus using high speed SV-AUC
SA Berkowitz, N Larson, G Bou-Assaf, T Laue
Analytical Biochemistry, 115482, 2024
22024
Subunit-based vaccines: challenges in developing protein-based vaccines
SF Ausar, NR Larson, Y Wei, A Jain, CR Middaugh
Practical Aspects of Vaccine Development, 79-135, 2022
22022
Chapter 7: An Empirical Phase Diagram: High-Throughput Screening Approach to the Characterization and Formulation of Biopharmaceuticals
Y Wei, SB Joshi, A Bhambhani, Y Zeng, NR Larson, G Hu, EJ Deeds, ...
Development of Biopharmaceutical Drug-Device Products, 139-185, 2020
22020
Development of UPLC-UV-ELSD Method for Fatty Acid Profiling in Polysorbate 80 and Confirmation of the Presence of Conjugated Fatty Acids by Mass Spectrometry, UV Absorbance and …
M Doyle, A Barnes, NR Larson, H Liu, L Yi
Journal of Pharmaceutical Sciences 112 (9), 2393-2403, 2023
12023
Conformational changes and drivers of monoclonal antibody liquid-liquid phase separation
NR Larson, Y Wei, TA Cruz, R Esfandiary, CK Kalonia, ML Forrest, ...
Journal of pharmaceutical sciences 112 (3), 680-690, 2023
12023
Visible Light Degradation of a Monoclonal Antibody in a High-Concentration Formulation: Characterization of a Tryptophan-Derived Chromophoric Photo-product by Comparison to …
I Prajapati, NR Larson, S Choudhary, C Kalonia, S Hudak, R Esfandiary, ...
Molecular Pharmaceutics 18 (9), 3223-3234, 2021
12021
Development and Application of Spectroscopic Techniques for Characterizing Turbid Solutions of Biopharmaceuticals
NR Larson
University of Kansas, 2020
12020
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