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Timothy Osborne
Timothy Osborne
Professor of Medicine, Biological Chemistry and Pediatrics Johns Hopkins Medicine
Verified email at jh.edu - Homepage
Title
Cited by
Cited by
Year
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ...
autophagy 17 (1), 1-382, 2021
96402021
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
DJ Klionsky, H Abeliovich, P Agostinis, DK Agrawal, G Aliev, DS Askew, ...
Autophagy 4 (2), 151-175, 2008
26652008
Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors
SB Joseph, BA Laffitte, PH Patel, MA Watson, KE Matsukuma, R Walczak, ...
Journal of Biological Chemistry 277 (13), 11019-11025, 2002
8912002
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway
WA Freed-Pastor, H Mizuno, X Zhao, A Langer°d, SH Moon, ...
Cell 148 (1-2), 244-258, 2012
8322012
Sterol regulatory element-binding proteins (SREBPs): key regulators of nutritional homeostasis and insulin action
TF Osborne
Journal of Biological Chemistry 275 (42), 32379-32382, 2000
6632000
HMG CoA reductase: a negatively regulated gene with unusual promoter and 5′ untranslated regions
GA Reynolds, SK Basu, TF Osborne, DJ Chin, G Gil, MS Brown, ...
Cell 38 (1), 275-285, 1984
5671984
SREBPs: metabolic integrators in physiology and metabolism
TI Jeon, TF Osborne
Trends in Endocrinology & Metabolism 23 (2), 65-72, 2012
5212012
Sterol regulatory element–binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity
Y Kidani, H Elsaesser, MB Hock, L Vergnes, KJ Williams, JP Argus, ...
Nature immunology 14 (5), 489-499, 2013
4252013
Sterol Regulation of Fatty Acid Synthase Promoter: COORDINATE FEEDBACK REGULATION OF TWO MAJOR LIPID PATHWAYS (∗)
MK Bennett, JM Lopez, HB Sanchez, TF Osborne
Journal of Biological Chemistry 270 (43), 25578-25583, 1995
4211995
Two tandem binding sites for sterol regulatory element binding proteins are required for sterol regulation of fatty-acid synthase promoter
MM Maga˝a, TF Osborne
Journal of Biological Chemistry 271 (51), 32689-32694, 1996
3941996
A feed-forward loop amplifies nutritional regulation of PNPLA3
Y Huang, S He, JZ Li, YK Seo, TF Osborne, JC Cohen, HH Hobbs
Proceedings of the National Academy of Sciences 107 (17), 7892-7897, 2010
3902010
Polyunsaturated fatty acids decrease expression of promoters with sterol regulatory elements by decreasing levels of mature sterol regulatory element-binding protein
TS Worgall, SL Sturley, T Seo, TF Osborne, RJ Deckelbaum
Journal of Biological Chemistry 273 (40), 25537-25540, 1998
3581998
Thyroid hormone regulation and cholesterol metabolism are connected through sterol regulatory element-binding protein-2 (SREBP-2)
DJ Shin, TF Osborne
Journal of Biological Chemistry 278 (36), 34114-34118, 2003
3542003
Cooperation by Sterol Regulatory Element-binding Protein and Sp1 in Sterol Regulation of Low Density Lipoprotein Receptor Gene (∗)
HB Sanchez, L Yieh, TF Osborne
Journal of Biological Chemistry 270 (3), 1161-1169, 1995
3531995
Linking lipid metabolism to the innate immune response in macrophages through sterol regulatory element binding protein-1a
SS Im, L Yousef, C Blaschitz, JZ Liu, RA Edwards, SG Young, M Raffatellu, ...
Cell metabolism 13 (5), 540-549, 2011
3362011
Identification of nucleotides responsible for enhancer activity of sterol regulatory element in low density lipoprotein receptor gene.
JR Smith, TF Osborne, JL Goldstein, MS Brown
Journal of Biological Chemistry 265 (4), 2306-2310, 1990
3011990
A Direct Role for Sterol Regulatory Element Binding Protein in Activation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Gene (∗)
SM Vallett, HB Sanchez, JM Rosenfeld, TF Osborne
Journal of Biological Chemistry 271 (21), 12247-12253, 1996
2771996
Host defense against viral infection involves interferon mediated down-regulation of sterol biosynthesis
M Blanc, WY Hsieh, KA Robertson, S Watterson, G Shui, P Lacaze, ...
PLoS biology 9 (3), e1000598, 2011
2742011
Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism
S Masri, P Rigor, M Cervantes, N Ceglia, C Sebastian, C Xiao, ...
Cell 158 (3), 659-672, 2014
2652014
Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been
TF Osborne, PJ Espenshade
Genes & development 23 (22), 2578-2591, 2009
2582009
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