Tara Spires-Jones
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Tau suppression in a neurodegenerative mouse model improves memory function
K Santacruz, J Lewis, T Spires, J Paulson, L Kotilinek, M Ingelsson, ...
Science 309 (5733), 476-481, 2005
Propagation of tau pathology in a model of early Alzheimer's disease
A De Calignon, M Polydoro, M Suárez-Calvet, C William, DH Adamowicz, ...
Neuron 73 (4), 685-697, 2012
Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease
M Meyer-Luehmann, TL Spires-Jones, C Prada, M Garcia-Alloza, ...
Nature 451 (7179), 720-724, 2008
The intersection of amyloid beta and tau at synapses in Alzheimer’s disease
TL Spires-Jones, BT Hyman
Neuron 82 (4), 756-771, 2014
Oligomeric amyloid β associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques
RM Koffie, M Meyer-Luehmann, T Hashimoto, KW Adams, ML Mielke, ...
Proceedings of the National Academy of Sciences 106 (10), 4012-4017, 2009
Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy
TL Spires, M Meyer-Luehmann, EA Stern, PJ McLean, J Skoch, ...
Journal of Neuroscience 25 (31), 7278-7287, 2005
Caspase activation precedes and leads to tangles
A De Calignon, LM Fox, R Pitstick, GA Carlson, BJ Bacskai, ...
Nature 464 (7292), 1201-1204, 2010
Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo
TA Fulga, I Elson-Schwab, V Khurana, ML Steinhilb, TL Spires, BT Hyman, ...
Nature cell biology 9 (2), 139-148, 2007
The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system
HC Tai, A Serrano-Pozo, T Hashimoto, MP Frosch, TL Spires-Jones, ...
The American journal of pathology 181 (4), 1426-1435, 2012
Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy
TL Spires, JD Orne, K SantaCruz, R Pitstick, GA Carlson, KH Ashe, ...
The American journal of pathology 168 (5), 1598-1607, 2006
Environmental enrichment rescues protein deficits in a mouse model of Huntington's disease, indicating a possible disease mechanism
TL Spires, HE Grote, NK Varshney, PM Cordery, A Van Dellen, ...
Journal of Neuroscience 24 (9), 2270-2276, 2004
Amyloid β induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation
HY Wu, E Hudry, T Hashimoto, K Kuchibhotla, A Rozkalne, Z Fan, ...
Journal of Neuroscience 30 (7), 2636-2649, 2010
Tau pathophysiology in neurodegeneration: a tangled issue
TL Spires-Jones, WH Stoothoff, A de Calignon, PB Jones, BT Hyman
Trends in neurosciences 32 (3), 150-159, 2009
Interactions of pathological proteins in neurodegenerative diseases
TL Spires-Jones, J Attems, DR Thal
Acta neuropathologica 134, 187-205, 2017
Tau association with synaptic vesicles causes presynaptic dysfunction
L Zhou, J McInnes, K Wierda, M Holt, AG Herrmann, RJ Jackson, ...
Nature communications 8 (1), 1-13, 2017
Apolipoprotein E4 effects in Alzheimer’s disease are mediated by synaptotoxic oligomeric amyloid-β
RM Koffie, T Hashimoto, HC Tai, KR Kay, A Serrano-Pozo, D Joyner, ...
Brain 135 (7), 2155-2168, 2012
Alzheimer's disease: synapses gone cold
RM Koffie, BT Hyman, TL Spires-Jones
Molecular neurodegeneration 6, 1-9, 2011
Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide
T Hashimoto, A Serrano-Pozo, Y Hori, KW Adams, S Takeda, AO Banerji, ...
Journal of Neuroscience 32 (43), 15181-15192, 2012
Transgenic models of Alzheimer's disease: learning from animals
TL Spires, BT Hyman
NeuroRx 2 (3), 423-437, 2005
The physiological roles of tau and Aβ: implications for Alzheimer’s disease pathology and therapeutics
SA Kent, TL Spires-Jones, CS Durrant
Acta neuropathologica 140 (4), 417-447, 2020
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