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T.J. Sego
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Building digital twins of the human immune system: toward a roadmap
R Laubenbacher, A Niarakis, T Helikar, G An, B Shapiro, RS Malik-Sheriff, ...
npj Digital Medicine 5 (1), 64, 2022
512022
A modular framework for multiscale, multicellular, spatiotemporal modeling of acute primary viral infection and immune response in epithelial tissues and its application to …
TJ Sego, JO Aponte-Serrano, JF Gianlupi, SR Heaps, K Breithaupt, ...
PLoS Computational Biology, 2020
512020
A heuristic computational model of basic cellular processes and oxygenation during spheroid-dependent biofabrication
TJ Sego, U Kasacheuski, D Hauersperger, A Tovar, NI Moldovan
Biofabrication 9 (2), 024104, 2017
272017
Compartmental model suggests importance of innate immune response to COVID-19 infection in rhesus macaques
E Mochan, TJ Sego, L Gaona, E Rial, GB Ermentrout
Bulletin of mathematical biology 83 (7), 79, 2021
152021
Computational Fluid Dynamic Analysis of Bioprinted Self‐Supporting Perfused (SSuPer) Tissue Models
TJ Sego, M Prideaux, J Sterner, BP McCarthy, P Li, LF Bonewald, B Ekser, ...
Biotechnology and Bioengineering, 2019
142019
Multiscale Model of Antiviral Timing, Potency, and Heterogeneity Effects on an Epithelial Tissue Patch Infected by SARS-CoV-2
J Ferrari Gianlupi, T Mapder, TJ Sego, JP Sluka, SK Quinney, M Craig, ...
Viruses 14 (3), 605, 2022
132022
Multicellular spatial model of RNA virus replication and interferon responses reveals factors controlling plaque growth dynamics
JO Aponte-Serrano, JJA Weaver, TJ Sego, JA Glazier, JE Shoemaker
PLoS Computational Biology 17 (10), e1008874, 2021
132021
A multiscale multicellular spatiotemporal model of local influenza infection and immune response
TJ Sego, ED Mochan, GB Ermentrout, JA Glazier
Journal of Theoretical Biology 532, 110918, 2022
122022
Generation of multicellular spatiotemporal models of population dynamics from ordinary differential equations, with applications in viral infection
TJ Sego, JO Aponte-Serrano, JF Gianlupi, JA Glazier
BMC biology 19, 1-24, 2021
112021
Advancing therapies for viral infections using mechanistic computational models of the dynamic interplay between the virus and host immune response
VI Zarnitsyna, JF Gianlupi, A Hagar, TJ Sego, JA Glazier
Current Opinion in Virology 50, 103-109, 2021
102021
A Modular Framework for Multiscale Spatial Modeling of Viral Infection and Immune Response in Epithelial Tissue
TJ Sego, JO Aponte-Serrano, J Ferrari-Gianlupi, S Heaps, EM Quardokus, ...
bioRxiv, 2020.04. 27.064139, 2020
82020
Tissue forge: interactive biological and biophysics simulation environment
TJ Sego, JP Sluka, HM Sauro, JA Glazier
PLOS Computational Biology 19 (10), e1010768, 2023
62023
Unification of aggregate growth models by emergence from cellular and intracellular mechanisms
TJ Sego, JA Glazier, A Tovar
Royal Society Open Science 7 (8), 192148, 2020
52020
Building digital twins of the human immune system: toward a roadmap. npj Digital Medicine 5
R Laubenbacher, A Niarakis, T Helikar, G An, B Shapiro, R Malik-Sheriff, ...
42022
Generating Agent-Based Multiscale Multicellular Spatiotemporal Models from Ordinary Differential Equations of Biological Systems, with Applications in Viral Infection
TJ Sego, JO Aponte-Serrano, JF Gianlupi, JA Glazier
bioRxiv, 2021.01. 28.428647, 2021
42021
Modeling progressive damage accumulation in bone remodeling explains the thermodynamic basis of bone resorption by overloading
TJ Sego, YT Hsu, TM Chu, A Tovar
Bulletin of Mathematical Biology 82, 1-23, 2020
42020
Towards the Optimal Crown-to-Implant Ratio in Dental Implants
TJ Sego, YT Hsu, TMG Chu, A Tovar
ASME 2017 International Design Engineering Technical Conferences and …, 2017
32017
General, open-source vertex modeling in biological applications using Tissue Forge
TJ Sego, T Comlekoglu, SM Peirce, DW Desimone, JA Glazier
Scientific Reports 13 (1), 17886, 2023
22023
Hybrid Kinetic Monte Carlo Models of Cellular Processes in Interactive Dynamic Microenvironments
TJ Sego
Purdue University, 2019
22019
Agent-Based Numerical Methods for 3D Bioprinting in Tissue Engineering
TJ Sego, NI Moldovan, A Tovar
Numerical Methods and Advanced Simulation in Biomechanics and Biological …, 2018
22018
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Articles 1–20