Jason D. Graci
Jason D. Graci
Principal Scientist, PTC Therapeutics Inc.
Verified email at
Cited by
Cited by
Mechanisms of action of ribavirin against distinct viruses
JD Graci, CE Cameron
Reviews in medical virology 16 (1), 37-48, 2006
Quasispecies, error catastrophe, and the antiviral activity of ribavirin
JD Graci, CE Cameron
Virology 298 (2), 175-180, 2002
RNA virus population diversity, an optimum for maximal fitness and virulence
VK Korboukh, CA Lee, A Acevedo, M Vignuzzi, Y Xiao, JJ Arnold, ...
Journal of Biological Chemistry 289 (43), 29531-29544, 2014
Therapeutically targeting RNA viruses via lethal mutagenesis
JD Graci, CE Cameron
Future Medicine 3 (6), 553-566, 2008
Mutational robustness of an RNA virus influences sensitivity to lethal mutagenesis
JD Graci, NF Gnädig, JE Galarraga, C Castro, M Vignuzzi, CE Cameron
Journal of virology 86 (5), 2869-2873, 2012
Lethal mutagenesis of picornaviruses with N-6-modified purine nucleoside analogues
JD Graci, K Too, ED Smidansky, JP Edathil, EW Barr, DA Harki, ...
Antimicrobial agents and chemotherapy 52 (3), 971-979, 2008
Synthesis and antiviral activity of 5-substituted cytidine analogues: identification of a potent inhibitor of viral RNA-dependent RNA polymerases
DA Harki, JD Graci, JE Galarraga, WJ Chain, CE Cameron, BR Peterson
Journal of medicinal chemistry 49 (21), 6166-6169, 2006
Lethal mutagenesis of poliovirus mediated by a mutagenic pyrimidine analogue
JD Graci, DA Harki, VS Korneeva, JP Edathil, K Too, D Franco, ...
Journal of virology 81 (20), 11256-11266, 2007
Synthesis and antiviral evaluation of a mutagenic and non-hydrogen bonding ribonucleoside analogue: 1-β-d-ribofuranosyl-3-nitropyrrole
DA Harki, JD Graci, VS Korneeva, SKB Ghosh, Z Hong, CE Cameron, ...
Biochemistry 41 (29), 9026-9033, 2002
Targeting of hematologic malignancies with PTC299, a novel potent inhibitor of dihydroorotate dehydrogenase with favorable pharmaceutical properties
L Cao, M Weetall, C Trotta, K Cintron, J Ma, MJ Kim, B Furia, C Romfo, ...
Molecular cancer therapeutics 18 (1), 3-16, 2019
Structure–activity relationship (SAR) optimization of 6-(indol-2-yl) pyridine-3-sulfonamides: identification of potent, selective, and orally bioavailable small molecules …
N Zhang, X Zhang, J Zhu, A Turpoff, G Chen, C Morrill, S Huang, ...
Journal of Medicinal Chemistry 57 (5), 2121-2135, 2014
Challenges for the development of ribonucleoside analogues as inducers of error catastrophe
JD Graci, CE Cameron
Antiviral Chemistry and Chemotherapy 15 (1), 1-13, 2004
High-throughput screening uncovers a compound that activates latent HIV-1 and acts cooperatively with a histone deacetylase (HDAC) inhibitor
S Micheva-Viteva, Y Kobayashi, LC Edelstein, AL Pacchia, HLR Lee, ...
Journal of Biological Chemistry 286 (24), 21083-21091, 2011
Effects of introduction of hydrophobic group on ribavirin base on mutation induction and anti-RNA viral activity
K Moriyama, T Suzuki, K Negishi, JD Graci, CN Thompson, CE Cameron, ...
Journal of medicinal chemistry 51 (1), 159-166, 2008
The DHODH inhibitor PTC299 arrests SARS-CoV-2 replication and suppresses induction of inflammatory cytokines
J Luban, RA Sattler, E Mühlberger, JD Graci, L Cao, M Weetall, C Trotta, ...
Virus research 292, 198246, 2021
Discovery of novel HCV inhibitors: synthesis and biological activity of 6-(indol-2-yl) pyridine-3-sulfonamides targeting hepatitis C virus NS4B
X Zhang, N Zhang, G Chen, A Turpoff, H Ren, J Takasugi, C Morrill, J Zhu, ...
Bioorganic & medicinal chemistry letters 23 (13), 3947-3953, 2013
Synthesis of a universal 5‐nitroindole ribonucleotide and incorporation into RNA by a viral RNA‐dependent RNA polymerase
DA Harki, JD Graci, JP Edathil, C Castro, CE Cameron, BR Peterson
Chembiochem 8 (12), 1359-1362, 2007
Identification of PTC725, an orally bioavailable small molecule that selectively targets the hepatitis C virus NS4B protein
Z Gu, JD Graci, FC Lahser, JJ Breslin, SP Jung, JH Crona, P McMonagle, ...
Antimicrobial agents and chemotherapy 57 (7), 3250-3261, 2013
6-(Azaindol-2-yl) pyridine-3-sulfonamides as potent and selective inhibitors targeting hepatitis C virus NS4B
G Chen, H Ren, N Zhang, W Lennox, A Turpoff, S Paget, C Li, N Almstead, ...
Bioorganic & Medicinal Chemistry Letters 25 (4), 781-786, 2015
Small molecule splicing modifiers with systemic HTT-lowering activity
A Bhattacharyya, CR Trotta, J Narasimhan, KJ Wiedinger, W Li, ...
Nature communications 12 (1), 1-12, 2021
The system can't perform the operation now. Try again later.
Articles 1–20