Paul Seidler, Ph.D.
Cited by
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Formation, structure, and reactivity of amino-terminated organic films on silicon substrates
J Kim, P Seidler, LS Wan, C Fill
Journal of colloid and interface science 329 (1), 114-119, 2009
Structure-based inhibitors of tau aggregation
PM Seidler, DR Boyer, JA Rodriguez, MR Sawaya, D Cascio, K Murray, ...
Nature chemistry 10 (2), 170-176, 2018
Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2
PD Patel, P Yan, PM Seidler, HJ Patel, W Sun, C Yang, NS Que, ...
Nature chemical biology 9 (11), 677-684, 2013
Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED
MJ De La Cruz, J Hattne, D Shi, P Seidler, J Rodriguez, FE Reyes, ...
Nature methods 14 (4), 399-402, 2017
Investigations of chemical modifications of amino-terminated organic films on silicon substrates and controlled protein immobilization
J Kim, J Cho, PM Seidler, NE Kurland, VK Yadavalli
Langmuir 26 (4), 2599-2608, 2010
Investigations of the effect of curing conditions on the structure and stability of amino-functionalized organic films on silicon substrates by Fourier transform infrared …
J Kim, P Seidler, C Fill, LS Wan
Surface Science 602 (21), 3323-3330, 2008
Structure-based inhibitors of amyloid beta core suggest a common interface with tau
SL Griner, P Seidler, J Bowler, KA Murray, TP Yang, S Sahay, ...
Elife 8, e46924, 2019
Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation
WS Shin, J Di, Q Cao, B Li, PM Seidler, KA Murray, G Bitan, L Jiang
Alzheimer's research & therapy 11, 1-13, 2019
Structure-based discovery of small molecules that disaggregate Alzheimer’s disease tissue derived tau fibrils in vitro
PM Seidler, KA Murray, DR Boyer, P Ge, MR Sawaya, CJ Hu, X Cheng, ...
Nature communications 13 (1), 5451, 2022
Structure-based inhibitors halt prion-like seeding by Alzheimer’s disease–and tauopathy–derived brain tissue samples
PM Seidler, DR Boyer, KA Murray, TP Yang, M Bentzel, MR Sawaya, ...
Journal of Biological Chemistry 294 (44), 16451-16464, 2019
Common fibrillar spines of amyloid-β and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors
P Krotee, SL Griner, MR Sawaya, D Cascio, JA Rodriguez, D Shi, ...
Journal of Biological Chemistry 293 (8), 2888-2902, 2018
De novo designed protein inhibitors of amyloid aggregation and seeding
KA Murray, CJ Hu, SL Griner, H Pan, JT Bowler, R Abskharon, ...
Proceedings of the National Academy of Sciences 119 (34), e2206240119, 2022
Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease
R Abskharon, PM Seidler, MR Sawaya, D Cascio, TP Yang, S Philipp, ...
Journal of Biological Chemistry 295 (31), 10662-10676, 2020
Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2
E Tayeb-Fligelman, X Cheng, C Tai, JT Bowler, S Griner, MR Sawaya, ...
BioRxiv, 2021.03. 05.434000, 2021
Characterization of the Grp94/OS-9 chaperone–lectin complex
PM Seidler, SA Shinsky, F Hong, Z Li, MS Cosgrove, DT Gewirth
Journal of molecular biology 426 (21), 3590-3605, 2014
Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils
KA Murray, CJ Hu, H Pan, J Lu, R Abskharon, JT Bowler, GM Rosenberg, ...
Proceedings of the National Academy of Sciences 120 (7), e2217835120, 2023
Identifying amyloid-related diseases by mapping mutations in low-complexity protein domains to pathologies
KA Murray, MP Hughes, CJ Hu, MR Sawaya, L Salwinski, H Pan, ...
Nature structural & molecular biology 29 (6), 529-536, 2022
CryoEM reveals how the small molecule EGCG binds to Alzheimer’s brain-derived tau fibrils and initiates fibril disaggregation
PM Seidler, DR Boyer, MR Sawaya, P Ge, WS Shin, MA DeTure, ...
bioRxiv, 2020.05. 29.124537, 2020
Three‐repeat and four‐repeat tau isoforms form different oligomers
H Shahpasand‐Kroner, J Portillo, C Lantz, PM Seidler, N Sarafian, JA Loo, ...
Protein Science 31 (3), 613-627, 2022
Structure-based inhibitors of tau aggregation. Nat Chem 10: 170–176
PM Seidler, DR Boyer, JA Rodriguez, MR Sawaya, D Cascio, K Murray, ...
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Articles 1–20