Marco Vignuzzi
Marco Vignuzzi
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Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population
M Vignuzzi, JK Stone, JJ Arnold, CE Cameron, R Andino
Nature 439 (7074), 344-348, 2006
Coronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeutics
EC Smith, H Blanc, M Vignuzzi, MR Denison
PLoS pathogens 9 (8), e1003565, 2013
Engineering attenuated virus vaccines by controlling replication fidelity
M Vignuzzi, E Wendt, R Andino
Nature medicine 14 (2), 154-161, 2008
Evolutionary constraints on chaperone-mediated folding provide an antiviral approach refractory to development of drug resistance
R Geller, M Vignuzzi, R Andino, J Frydman
Genes & development 21 (2), 195-205, 2007
Arbovirus high fidelity variant loses fitness in mosquitoes and mice
LL Coffey, Y Beeharry, AV Bordería, H Blanc, M Vignuzzi
Proceedings of the National Academy of Sciences 108 (38), 16038-16043, 2011
Harnessing endogenous miRNAs to control virus tissue tropism as a strategy for developing attenuated virus vaccines
D Barnes, M Kunitomi, M Vignuzzi, K Saksela, R Andino
Cell host & microbe 4 (3), 239-248, 2008
Remote Site Control of an Active Site Fidelity Checkpoint in a ViralRNA-dependent RNAPolymerase
JJ Arnold, M Vignuzzi, JK Stone, R Andino, CE Cameron
Journal of Biological Chemistry 280 (27), 25706-25716, 2005
Ribavirin and lethal mutagenesis of poliovirus: molecular mechanisms, resistance and biological implications
M Vignuzzi, JK Stone, R Andino
Virus research 107 (2), 173-181, 2005
Host alternation of chikungunya virus increases fitness while restricting population diversity and adaptability to novel selective pressures
LL Coffey, M Vignuzzi
Journal of virology 85 (2), 1025-1035, 2011
Coxsackievirus B3 mutator strains are attenuated in vivo
NF Gnädig, S Beaucourt, G Campagnola, AV Bordería, M Sanz-Ramos, ...
Proceedings of the National Academy of Sciences 109 (34), E2294-E2303, 2012
Group selection and contribution of minority variants during virus adaptation determines virus fitness and phenotype
AV Bordería, O Isakov, G Moratorio, R Henningsson, S Agüera-González, ...
PLoS pathogens 11 (5), e1004838, 2015
Ribavirin: a drug active against many viruses with multiple effects on virus replication and propagation. Molecular basis of ribavirin resistance
S Beaucourt, M Vignuzzi
Current opinion in virology 8, 10-15, 2014
Emergence and transmission of arbovirus evolutionary intermediates with epidemic potential
KA Stapleford, LL Coffey, S Lay, AV Bordería, V Duong, O Isakov, ...
Cell host & microbe 15 (6), 706-716, 2014
RNA virus population diversity, an optimum for maximal fitness and virulence
VK Korboukh, CA Lee, A Acevedo, M Vignuzzi, Y Xiao, JJ Arnold, ...
Journal of Biological Chemistry 289 (43), 29531-29544, 2014
Alphavirus mutator variants present host-specific defects and attenuation in mammalian and insect models
K Rozen-Gagnon, KA Stapleford, V Mongelli, H Blanc, AB Failloux, ...
PLoS Pathogens 10 (1), e1003877, 2014
Structure-function relationships underlying the replication fidelity of viral RNA-dependent RNA polymerases
G Campagnola, S McDonald, S Beaucourt, M Vignuzzi, OB Peersen
Journal of Virology 89 (1), 275-286, 2015
Fidelity variants of RNA dependent RNA polymerases uncover an indirect, mutagenic activity of amiloride compounds
LI Levi, NF Gnädig, S Beaucourt, MJ McPherson, B Baron, JJ Arnold, ...
PLoS pathogens 6 (10), e1001163, 2010
Phylogenetic and genome-wide deep-sequencing analyses of canine parvovirus reveal co-infection with field variants and emergence of a recent recombinant strain
R Pérez, L Calleros, A Marandino, N Sarute, G Iraola, S Grecco, H Blanc, ...
PLoS One 9 (11), e111779, 2014
Mutational robustness of an RNA virus influences sensitivity to lethal mutagenesis
JD Graci, NF Gnädig, JE Galarraga, C Castro, M Vignuzzi, CE Cameron
Journal of virology 86 (5), 2869-2873, 2012
Naked RNA immunization with replicons derived from poliovirus and Semliki Forest virus genomes for the generation of a cytotoxic T cell response against the influenza A virus …
M Vignuzzi, S Gerbaud, S van der Werf, N Escriou
Journal of General Virology 82 (7), 1737-1747, 2001
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