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Farren Isaacs
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Programming cells by multiplex genome engineering and accelerated evolution
HH Wang, FJ Isaacs, PA Carr, ZZ Sun, G Xu, CR Forest, GM Church
Nature 460 (7257), 894-898, 2009
18172009
Genomically recoded organisms expand biological functions
MJ Lajoie, AJ Rovner, DB Goodman, HR Aerni, AD Haimovich, ...
science 342 (6156), 357-360, 2013
9312013
Computational studies of gene regulatory networks: in numero molecular biology
J Hasty, D McMillen, F Isaacs, JJ Collins
Nature Reviews Genetics 2 (4), 268-279, 2001
8122001
Phenotypic consequences of promoter-mediated transcriptional noise
WJ Blake, G Balázsi, MA Kohanski, FJ Isaacs, KF Murphy, Y Kuang, ...
Molecular cell 24 (6), 853-865, 2006
7112006
Engineered riboregulators enable post-transcriptional control of gene expression
FJ Isaacs, DJ Dwyer, C Ding, DD Pervouchine, CR Cantor, JJ Collins
Nature biotechnology 22 (7), 841-847, 2004
7032004
Precise manipulation of chromosomes in vivo enables genome-wide codon replacement
FJ Isaacs, PA Carr, HH Wang, MJ Lajoie, B Sterling, L Kraal, AC Tolonen, ...
Science 333 (6040), 348-353, 2011
6612011
Prediction and measurement of an autoregulatory genetic module
FJ Isaacs, J Hasty, CR Cantor, JJ Collins
Proceedings of the National Academy of Sciences 100 (13), 7714-7719, 2003
5672003
A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes
L Bazak, A Haviv, M Barak, J Jacob-Hirsch, P Deng, R Zhang, FJ Isaacs, ...
Genome research 24 (3), 365-376, 2014
5372014
The real cost of sequencing: scaling computation to keep pace with data generation
P Muir, S Li, S Lou, D Wang, DJ Spakowicz, L Salichos, J Zhang, ...
Genome biology 17 (1), 1-9, 2016
4812016
RNA synthetic biology
FJ Isaacs, DJ Dwyer, JJ Collins
Nature biotechnology 24 (5), 545-554, 2006
4662006
Recoded organisms engineered to depend on synthetic amino acids
AJ Rovner, AD Haimovich, SR Katz, Z Li, MW Grome, BM Gassaway, ...
Nature 518 (7537), 89-93, 2015
3672015
Designer gene networks: Towards fundamental cellular control
J Hasty, F Isaacs, M Dolnik, D McMillen, JJ Collins
Chaos: An Interdisciplinary Journal of Nonlinear Science 11 (1), 207-220, 2001
3522001
Engineering an allosteric transcription factor to respond to new ligands
ND Taylor, AS Garruss, R Moretti, S Chan, MA Arbing, D Cascio, ...
Nature methods 13 (2), 177-183, 2016
3082016
The genome project-write
JD Boeke, G Church, A Hessel, NJ Kelley, A Arkin, Y Cai, R Carlson, ...
Science 353 (6295), 126-127, 2016
2802016
Evolution of translation machinery in recoded bacteria enables multi-site incorporation of nonstandard amino acids
M Amiram, AD Haimovich, C Fan, YS Wang, HR Aerni, I Ntai, DW Moonan, ...
Nature biotechnology 33 (12), 1272-1279, 2015
2722015
Tracking, tuning, and terminating microbial physiology using synthetic riboregulators
JM Callura, DJ Dwyer, FJ Isaacs, CR Cantor, JJ Collins
Proceedings of the National Academy of Sciences 107 (36), 15898-15903, 2010
2142010
Potent noncovalent inhibitors of the main protease of SARS-CoV-2 from molecular sculpting of the drug perampanel guided by free energy perturbation calculations
CH Zhang, EA Stone, M Deshmukh, JA Ippolito, MM Ghahremanpour, ...
ACS central science 7 (3), 467-475, 2021
2092021
Cell-free protein synthesis from genomically recoded bacteria enables multisite incorporation of noncanonical amino acids
RW Martin, BJ Des Soye, YC Kwon, J Kay, RG Davis, PM Thomas, ...
Nature communications 9 (1), 1203, 2018
2062018
Cell-free Protein Synthesis from a Release Factor 1 Deficient Escherichia coli Activates Efficient and Multiple Site-specific Nonstandard Amino Acid Incorporation
SH Hong, I Ntai, AD Haimovich, NL Kelleher, FJ Isaacs, MC Jewett
ACS synthetic biology 3 (6), 398-409, 2014
1632014
Crystal structure of an insect antifreeze protein and its implications for ice binding
A Hakim, JB Nguyen, K Basu, DF Zhu, D Thakral, PL Davies, FJ Isaacs, ...
Journal of Biological Chemistry 288 (17), 12295-12304, 2013
1412013
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Articles 1–20