| Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel B Li, P Ge, KA Murray, P Sheth, M Zhang, G Nair, MR Sawaya, WS Shin, ... Nature communications 9 (1), 3609, 2018 | 453 | 2018 |
| Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly X Gui, F Luo, Y Li, H Zhou, Z Qin, Z Liu, J Gu, M Xie, K Zhao, B Dai, ... Nature communications 10 (1), 2006, 2019 | 142 | 2019 |
| Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation WS Shin, J Di, Q Cao, B Li, PM Seidler, KA Murray, G Bitan, L Jiang Alzheimer's research & therapy 11 (1), 1-13, 2019 | 97 | 2019 |
| Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design. JL Cao Q, Shin WS, Chan H, Vuong CK, Dubois B, Li B, Murray KA, Sawaya MR ... Natature Chemistry 10 (s41557-018-0147-z), 2018 | 50* | 2018 |
| Thymidylate kinase: an old topic brings new perspectives Q Cui, W S Shin, Y Luo, J Tian, H Cui, D Yin Current medicinal chemistry 20 (10), 1286-1305, 2013 | 45 | 2013 |
| Anti-inflammatory effect of avenanthramides via NF-κB pathways in C2C12 skeletal muscle cells C Kang, WS Shin, D Yeo, W Lim, T Zhang, LL Ji Free Radical Biology and Medicine 117, 30-36, 2018 | 36 | 2018 |
| Discovery of 1-hydroxypyridine-2-thiones as selective histone deacetylase inhibitors and their potential application for treating leukemia R Muthyala, WS Shin, J Xie, YY Sham Bioorganic & medicinal chemistry letters 25 (19), 4320-4324, 2015 | 32 | 2015 |
| Different amyloid-β self-assemblies have distinct effects on intracellular tau aggregation WS Shin, J Di, KA Murray, C Sun, B Li, G Bitan, L Jiang Frontiers in molecular neuroscience 12, 268, 2019 | 19 | 2019 |
| Discovery of 1‐Hydroxypyridine‐2(1H)‐thione‐6‐carboxylic Acid as a First‐in‐Class Low‐Cytotoxic Nanomolar Metallo β‐Lactamase Inhibitor WS Shin, A Bergstrom, RA Bonomo, MW Crowder, R Muthyala, YY Sham ChemMedChem 12 (11), 845-849, 2017 | 19 | 2017 |
| Nicotinamide mononucleotide adenylyltransferase uses its NAD+ substrate-binding site to chaperone phosphorylated Tau X Ma, Y Zhu, J Lu, J Xie, C Li, WS Shin, J Qiang, J Liu, S Dou, Y Xiao, ... elife 9, e51859, 2020 | 17 | 2020 |
| Ischemic axonal injury up-regulates MARK4 in cortical neurons and primes tau phosphorylation and aggregation EY Hayden, J Putman, S Nunez, WS Shin, M Oberoi, M Charreton, ... Acta neuropathologica communications 7, 1-12, 2019 | 17 | 2019 |
| Cell permeable vanX inhibitors as vancomycin re-sensitizing agents R Muthyala, N Rastogi, WS Shin, ML Peterson, YY Sham Bioorganic & medicinal chemistry letters 24 (11), 2535-2538, 2014 | 16 | 2014 |
| CryoEM reveals how the small molecule EGCG binds to Alzheimer’s brain-derived tau fibrils and initiates fibril disaggregation PM Seidler, DR Boyer, MR Sawaya, P Ge, WS Shin, MA DeTure, ... bioRxiv, 2020.05. 29.124537, 2020 | 11 | 2020 |
| A novel drug discovery strategy: Mechanistic investigation of an enantiomeric antitumor agent targeting dual p53 and NF-κB pathways C Zhuang, C Sheng, WS Shin, Y Wu, J Li, J Yao, G Dong, W Zhang, ... Oncotarget 5 (21), 10830, 2014 | 11 | 2014 |
| Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel. Nat Commun 9: 3609 B Li, P Ge, KA Murray, P Sheth, M Zhang, G Nair, MR Sawaya, WS Shin, ... | 7 | 2018 |
| Fragment‐based screening and hit‐based substructure search: Rapid discovery of 8‐hydroxyquinoline‐7‐carboxylic acid as a low‐cytotoxic, nanomolar metallo β‐lactamase inhibitor WS Shin, ME Nguyen, A Bergstrom, IR Jennings, MW Crowder, ... Chemical Biology & Drug Design 98 (4), 481-492, 2021 | 4 | 2021 |
| Data on the mode of binding between avenanthramides and IKKβ domains in a docking model C Kang, WS Shin, D Yeo, W Lim, LL Ji Data in brief 17, 994-997, 2018 | 3 | 2018 |
| Cryo-EM of full-length alpha-synuclein reveals fibril polymorphs with a common structural kernel. Nat Commun, 9 (1), 3609 B Li, P Ge, KA Murray, P Sheth, M Zhang, G Nair, MR Sawaya, WS Shin, ... | 3 | 2018 |
| O4‐01‐01: INHIBITING AMYLOID‐BETA CYTOTOXICITY THROUGH ITS INTERACTION WITH THE CELL SURFACE RECEPTOR LILRB2 BY STRUCTURE‐BASED DESIGN L Jiang, Q Cao, WS Shin, DS Eisenberg Alzheimer's & Dementia 15, P1229-P1229, 2019 | 2 | 2019 |
| Cryo-EM structure of amyloid fibril formed by α-synuclein hereditary A53E mutation reveals a distinct protofilament interface C Sun, K Zhou, P DePaola, WS Shin, T Hillyer, MR Sawaya, R Zhu, ... Journal of Biological Chemistry 299 (4), 2023 | 1 | 2023 |
Lin JiangAssociate Professor of Neurology, University of California, Los AngelesVerified email at ucla.edu
