| Activated ClpP kills persisters and eradicates a chronic biofilm infection BP Conlon, ES Nakayasu, LE Fleck, MD LaFleur, VM Isabella, K Coleman, ... Nature 503 (7476), 365-370, 2013 | 743 | 2013 |
| Pseudomonas aeruginosa Biofilms in Disease LR Mulcahy, VM Isabella, K Lewis Microbial ecology 68, 1-12, 2014 | 581 | 2014 |
| Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketonuria VM Isabella, BN Ha, MJ Castillo, DJ Lubkowicz, SE Rowe, YA Millet, ... Nature biotechnology 36 (9), 857-864, 2018 | 465 | 2018 |
| An engineered E. coli Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans CB Kurtz, YA Millet, MK Puurunen, M Perreault, MR Charbonneau, ... Science translational medicine 11 (475), eaau7975, 2019 | 289 | 2019 |
| Developing a new class of engineered live bacterial therapeutics to treat human diseases MR Charbonneau, VM Isabella, N Li, CB Kurtz Nature Communications 11 (1), 1738, 2020 | 261 | 2020 |
| Biochemical and genomic analysis of the denitrification pathway within the genus Neisseria KR Barth, VM Isabella, VL Clark Microbiology 155 (12), 4093-4103, 2009 | 97 | 2009 |
| Safety and pharmacodynamics of an engineered E. coli Nissle for the treatment of phenylketonuria: a first-in-human phase 1/2a study MK Puurunen, J Vockley, SL Searle, SJ Sacharow, JA Phillips III, ... Nature Metabolism 3 (8), 1125-1132, 2021 | 96 | 2021 |
| Analysis of the hierarchy of quorum-sensing regulation in Pseudomonas aeruginosa VE Wagner, LL Li, VM Isabella, BH Iglewski Analytical and bioanalytical chemistry 387, 469-479, 2007 | 91 | 2007 |
| Functional analysis of NsrR, a nitric oxide‐sensing Rrf2 repressor in Neisseria gonorrhoeae VM Isabella, JD Lapek Jr, EM Kennedy, VL Clark Molecular microbiology 71 (1), 227-239, 2009 | 89 | 2009 |
| Deep sequencing-based analysis of the anaerobic stimulon in Neisseria gonorrhoeae VM Isabella, VL Clark BMC genomics 12, 1-24, 2011 | 87 | 2011 |
| A genetic determinant of persister cell formation in bacterial pathogens DR Cameron, Y Shan, EA Zalis, V Isabella, K Lewis Journal of bacteriology 200 (17), 10.1128/jb. 00303-18, 2018 | 78 | 2018 |
| Toward the rational design of carbapenem uptake in Pseudomonas aeruginosa VM Isabella, AJ Campbell, J Manchester, M Sylvester, AS Nayar, ... Chemistry & biology 22 (4), 535-547, 2015 | 69 | 2015 |
| Thinking outside the “bug”: a unique assay to measure intracellular drug penetration in gram-negative bacteria Y Zhou, C Joubran, L Miller-Vedam, V Isabella, A Nayar, S Tentarelli, ... Analytical chemistry 87 (7), 3579-3584, 2015 | 69 | 2015 |
| Revisiting the Gram-negative lipoprotein paradigm ED LoVullo, LF Wright, V Isabella, JF Huntley, MS Pavelka Jr Journal of bacteriology 197 (10), 1705-1715, 2015 | 66 | 2015 |
| cis-and trans-acting elements involved in regulation of norB (norZ), the gene encoding nitric oxide reductase in Neisseria gonorrhoeae V Isabella, LF Wright, K Barth, JM Spence, S Grogan, CA Genco, VL Clark Microbiology 154 (1), 226-239, 2008 | 64 | 2008 |
| Improvement of a synthetic live bacterial therapeutic for phenylketonuria with biosensor-enabled enzyme engineering KJ Adolfsen, I Callihan, CE Monahan, PJ Greisen, J Spoonamore, ... Nature communications 12 (1), 6215, 2021 | 57 | 2021 |
| Characterization of novel respiratory syncytial virus inhibitors identified by high throughput screen VA Laganas, EF Dunn, RE McLaughlin, CL Tiong-Yip, O Yuzhakov, ... Antiviral Research 115, 71-74, 2015 | 25 | 2015 |
| An engineered bacterial therapeutic lowers urinary oxalate in preclinical models and in silico simulations of enteric hyperoxaluria D Lubkowicz, NG Horvath, MJ James, P Cantarella, L Renaud, ... Molecular Systems Biology 18 (3), e10539, 2022 | 21 | 2022 |
| Identification of a conserved protein involved in anaerobic unsaturated fatty acid synthesis in Neiserria gonorrhoeae: implications for facultative and obligate … VM Isabella, VL Clark Molecular microbiology 82 (2), 489-501, 2011 | 18 | 2011 |
| Killing persister cells and eradicating a biofilm infection by activating the ClpP protease BP Conlon, ES Nakayasu, LE Fleck, MD LaFleur, VM Isabella, K Coleman, ... Nature 503 (7476), 365, 2013 | 15 | 2013 |
