Benoit Lehallier
Benoit Lehallier
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Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris.
TM Consortium
Nature 562 (7727), 367, 2018
A single-cell transcriptomic atlas characterizes ageing tissues in the mouse
Nature 583 (7817), 590-595, 2020
Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain
J Marschallinger, T Iram, M Zardeneta, SE Lee, B Lehallier, MS Haney, ...
Nature neuroscience 23 (2), 194-208, 2020
Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease
D Gate, N Saligrama, O Leventhal, AC Yang, MS Unger, J Middeldorp, ...
Nature 577 (7790), 399-404, 2020
Undulating changes in human plasma proteome profiles across the lifespan
B Lehallier, D Gate, N Schaum, T Nanasi, SE Lee, H Yousef, ...
Nature medicine 25 (12), 1843-1850, 2019
Ageing hallmarks exhibit organ-specific temporal signatures
N Schaum, B Lehallier, O Hahn, R Pálovics, S Hosseinzadeh, SE Lee, ...
Nature 583 (7817), 596-602, 2020
Physiological blood–brain transport is impaired with age by a shift in transcytosis
AC Yang, MY Stevens, MB Chen, DP Lee, D Stähli, D Gate, K Contrepois, ...
Nature 583 (7816), 425-430, 2020
Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1
H Yousef, CJ Czupalla, D Lee, MB Chen, AN Burke, KA Zera, J Zandstra, ...
Nature medicine 25 (6), 988-1000, 2019
An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging
N Sayed, Y Huang, K Nguyen, Z Krejciova-Rajaniemi, AP Grawe, T Gao, ...
Nature aging 1 (7), 598-615, 2021
Exercise plasma boosts memory and dampens brain inflammation via clusterin
Z De Miguel, N Khoury, MJ Betley, B Lehallier, D Willoughby, N Olsson, ...
Nature 600 (7889), 494-499, 2021
Brain endothelial cells are exquisite sensors of age-related circulatory cues
MB Chen, AC Yang, H Yousef, D Lee, W Chen, N Schaum, B Lehallier, ...
Cell reports 30 (13), 4418-4432. e4, 2020
Preclinical assessment of young blood plasma for Alzheimer disease
J Middeldorp, B Lehallier, SA Villeda, SSM Miedema, E Evans, E Czirr, ...
JAMA neurology 73 (11), 1325-1333, 2016
Multiomics modeling of the immunome, transcriptome, microbiome, proteome and metabolome adaptations during human pregnancy
MS Ghaemi, DB DiGiulio, K Contrepois, B Callahan, TTM Ngo, ...
Bioinformatics 35 (1), 95-103, 2019
Activation of the STING-dependent type I interferon response reduces microglial reactivity and neuroinflammation
V Mathur, R Burai, RT Vest, LN Bonanno, B Lehallier, ME Zardeneta, ...
Neuron 96 (6), 1290-1302. e6, 2017
Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17
T Iram, F Kern, A Kaur, S Myneni, AR Morningstar, H Shin, MA Garcia, ...
Nature 605 (7910), 509-515, 2022
A proteomic clock of human pregnancy
N Aghaeepour, B Lehallier, Q Baca, EA Ganio, RJ Wong, MS Ghaemi, ...
American journal of obstetrics and gynecology 218 (3), 347. e1-347. e14, 2018
Systematic review and analysis of human proteomics aging studies unveils a novel proteomic aging clock and identifies key processes that change with age
AA Johnson, MN Shokhirev, T Wyss-Coray, B Lehallier
Ageing research reviews 60, 101070, 2020
Predicting early symptomatic osteoarthritis in the human knee using machine learning classification of magnetic resonance images from the osteoarthritis initiative
BG Ashinsky, M Bouhrara, CE Coletta, B Lehallier, KL Urish, PC Lin, ...
Journal of Orthopaedic Research 35 (10), 2243-2250, 2017
Data mining of human plasma proteins generates a multitude of highly predictive aging clocks that reflect different aspects of aging
B Lehallier, MN Shokhirev, T Wyss‐Coray, AA Johnson
Aging cell 19 (11), e13256, 2020
Combined plasma and cerebrospinal fluid signature for the prediction of midterm progression from mild cognitive impairment to Alzheimer disease
B Lehallier, L Essioux, J Gayan, R Alexandridis, T Nikolcheva, ...
JAMA neurology 73 (2), 203-212, 2016
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