Concomitant Raman spectroscopy and dynamic light scattering for characterization of therapeutic proteins at high concentrations C Zhou, W Qi, EN Lewis, JF Carpenter Analytical biochemistry 472, 7-20, 2015 | 112 | 2015 |
The effects of excipients on protein aggregation during agitation: an interfacial shear rheology study L Liu, W Qi, DK Schwartz, TW Randolph, JF Carpenter Journal of pharmaceutical sciences 102 (8), 2460-2470, 2013 | 109 | 2013 |
How well do low-and high-concentration protein interactions predict solution viscosities of monoclonal antibodies? MA Woldeyes, W Qi, VI Razinkov, EM Furst, CJ Roberts Journal of pharmaceutical sciences 108 (1), 142-154, 2019 | 80 | 2019 |
A safe, blood-brain barrier permeable triphenylmethane dye inhibits amyloid-β neurotoxicity by generating nontoxic aggregates HE Wong, W Qi, HM Choi, EJ Fernandez, I Kwon ACS chemical neuroscience 2 (11), 645-657, 2011 | 74 | 2011 |
Structural differences between Aβ (1-40) intermediate oligomers and fibrils elucidated by proteolytic fragmentation and hydrogen/deuterium exchange A Zhang, W Qi, TA Good, EJ Fernandez Biophysical journal 96 (3), 1091-1104, 2009 | 68 | 2009 |
Microparticles and nanoparticles delivered in intravenous saline and in an intravenous solution of a therapeutic antibody product NN Pardeshi, W Qi, K Dahl, L Caplan, JF Carpenter Journal of pharmaceutical sciences 106 (2), 511-520, 2017 | 63 | 2017 |
Combined dynamic light scattering and Raman spectroscopy approach for characterizing the aggregation of therapeutic proteins EN Lewis, W Qi, LH Kidder, S Amin, SM Kenyon, S Blake Molecules 19 (12), 20888-20905, 2014 | 55 | 2014 |
A new approach to explore the impact of freeze-thaw cycling on protein structure: hydrogen/deuterium exchange mass spectrometry (HX-MS) A Zhang, W Qi, SK Singh, EJ Fernandez Pharmaceutical research 28, 1179-1193, 2011 | 53 | 2011 |
Two Disaccharides and Trimethylamine N-Oxide Affect Aβ Aggregation Differently, but All Attenuate Oligomer-Induced Membrane Permeability W Qi, A Zhang, TA Good, EJ Fernandez Biochemistry 48 (37), 8908-8919, 2009 | 53 | 2009 |
Osmolyte effects on monoclonal antibody stability and concentration-dependent protein interactions with water and common osmolytes GV Barnett, VI Razinkov, BA Kerwin, S Blake, W Qi, RA Curtis, CJ Roberts The Journal of Physical Chemistry B 120 (13), 3318-3330, 2016 | 51 | 2016 |
Aggregate structure, morphology and the effect of aggregation mechanisms on viscosity at elevated protein concentrations GV Barnett, W Qi, S Amin, EN Lewis, CJ Roberts Biophysical Chemistry 207, 21-29, 2015 | 43 | 2015 |
Characterization of sizes of aggregates of insulin analogs and the conformations of the constituent protein molecules: a concomitant dynamic light scattering and Raman … C Zhou, W Qi, EN Lewis, JF Carpenter Journal of Pharmaceutical Sciences 105 (2), 551-558, 2016 | 41 | 2016 |
Temperature dependence of protein solution viscosity and protein–protein interactions: insights into the origins of high-viscosity protein solutions MA Woldeyes, W Qi, VI Razinkov, EM Furst, CJ Roberts Molecular pharmaceutics 17 (12), 4473-4482, 2020 | 40 | 2020 |
Simultaneous monitoring of peptide aggregate distributions, structure, and kinetics using amide hydrogen exchange: Application to Aβ (1‐40) fibrillogenesis W Qi, A Zhang, D Patel, S Lee, JL Harrington, L Zhao, D Schaefer, ... Biotechnology and bioengineering 100 (6), 1214-1227, 2008 | 40 | 2008 |
Characterization of nanoparticle tracking analysis for quantification and sizing of submicron particles of therapeutic proteins C Zhou, AB Krueger, JG Barnard, W Qi, JF Carpenter Journal of Pharmaceutical Sciences 104 (8), 2441-2450, 2015 | 37 | 2015 |
Effects of Excipients on the Chemical and Physical Stability of Glucagon during Freeze-Drying and Storage in Dried Formulations WJ Fang, W Qi, J Kinzell, S Prestrelski, JF Carpenter Pharmaceutical Research, 1-14, 2012 | 36 | 2012 |
Formation of stable nanobubbles on reconstituting lyophilized formulations containing trehalose C Zhou, D Cleland, J Snell, W Qi, TW Randolph, JF Carpenter Journal of Pharmaceutical Sciences 105 (7), 2249-2253, 2016 | 34 | 2016 |
Structural changes and aggregation mechanisms for anti-streptavidin IgG1 at elevated concentration GV Barnett, W Qi, S Amin, EN Lewis, VI Razinkov, BA Kerwin, Y Liu, ... The Journal of Physical Chemistry B 119 (49), 15150-15163, 2015 | 30 | 2015 |
Kinetics and competing mechanisms of antibody aggregation via bulk-and surface-mediated pathways CV Wood, S McEvoy, VI Razinkov, W Qi, EM Furst, CJ Roberts Journal of pharmaceutical sciences 109 (4), 1449-1459, 2020 | 28 | 2020 |
Membrane interactions of a self-assembling model peptide that mimics the self-association, structure and toxicity of Aβ (1–40) LC Salay, W Qi, B Keshet, LK Tamm, EJ Fernandez Biochimica et Biophysica Acta (BBA)-Biomembranes 1788 (9), 1714-1721, 2009 | 24 | 2009 |