Dr. James D. Johnson, PhD
Dr. James D. Johnson, PhD
Life Sciences Institute, University of British Columbia
Verified email at - Homepage
Cited by
Cited by
Guidelines for the use and interpretation of assays for monitoring autophagy
DJ Klionsky, FC Abdalla, H Abeliovich, RT Abraham, A Acevedo-Arozena, ...
Autophagy 8 (4), 445-544, 2012
Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells
A Rezania, JE Bruin, P Arora, A Rubin, I Batushansky, A Asadi, S O'dwyer, ...
Nature biotechnology 32 (11), 1121-1133, 2014
Hyperinsulinemia drives diet-induced obesity independently of brain insulin production
AE Mehran, NM Templeman, GS Brigidi, GE Lim, KY Chu, X Hu, ...
Cell metabolism 16 (6), 723-737, 2012
β-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment
LR Brunham, JK Kruit, TD Pape, JM Timmins, AQ Reuwer, Z Vasanji, ...
Nature medicine 13 (3), 340-347, 2007
Increased islet apoptosis in Pdx1+/– mice
JD Johnson, NT Ahmed, DS Luciani, Z Han, H Tran, J Fujita, S Misler, ...
The Journal of clinical investigation 111 (8), 1147-1160, 2003
Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet β cells
E Bernal-Mizrachi, S Fatrai, JD Johnson, M Ohsugi, K Otani, Z Han, ...
The Journal of clinical investigation 114 (7), 928-936, 2004
Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and β-cell death
DS Luciani, KS Gwiazda, TLB Yang, TB Kalynyak, Y Bychkivska, ...
Diabetes 58 (2), 422-432, 2009
Effects of palmitate on ER and cytosolic Ca2+ homeostasis in β-cells
KS Gwiazda, TLB Yang, Y Lin, JD Johnson
American Journal of Physiology-Endocrinology and Metabolism 296 (4), E690-E701, 2009
Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome
JD Johnson, E Bernal-Mizrachi, EU Alejandro, Z Han, TB Kalynyak, H Li, ...
Proceedings of the National Academy of Sciences 103 (51), 19575-19580, 2006
Reduced insulin production relieves endoplasmic reticulum stress and induces β cell proliferation
M Szabat, MM Page, E Panzhinskiy, S Skovs°, M Mojibian, ...
Cell metabolism 23 (1), 179-193, 2016
The carbohydrate-insulin model: a physiological perspective on the obesity pandemic
DS Ludwig, LJ Aronne, A Astrup, R de Cabo, LC Cantley, MI Friedman, ...
The American journal of clinical nutrition 114 (6), 1873-1885, 2021
Different effects of FK506, rapamycin, and mycophenolate mofetil on glucose-stimulated insulin release and apoptosis in human islets
JD Johnson, Z Ao, P Ao, H Li, LJ Dai, Z He, M Tee, KJ Potter, AM Klimek, ...
Cell transplantation 18 (8), 833-845, 2009
A causal role for hyperinsulinemia in obesity
NM Templeman, S Skovs°, MM Page, GE Lim, JD Johnson
Journal of Endocrinology 232 (3), R173-R183, 2017
A multi-year analysis of islet transplantation compared with intensive medical therapy on progression of complications in type 1 diabetes
GL Warnock, DM Thompson, RM Meloche, RJ Shapiro, Z Ao, P Keown, ...
Transplantation 86 (12), 1762-1766, 2008
Carboxypeptidase E mediates palmitate-induced β-cell ER stress and apoptosis
KD Jeffrey, EU Alejandro, DS Luciani, TB Kalynyak, X Hu, H Li, Y Lin, ...
Proceedings of the National Academy of Sciences 105 (24), 8452-8457, 2008
RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets
JD Johnson, Z Han, K Otani, H Ye, Y Zhang, H Wu, Y Horikawa, S Misler, ...
Journal of Biological Chemistry 279 (23), 24794-24802, 2004
Nicotinic acid-adenine dinucleotide phosphate-sensitive calcium stores initiate insulin signaling in human beta cells
JD Johnson, S Misler
Proceedings of the National Academy of Sciences 99 (22), 14566-14571, 2002
Characterization of polyhormonal insulin-producing cells derived in vitro from human embryonic stem cells
JE Bruin, S Erener, J Vela, X Hu, JD Johnson, HT Kurata, FC Lynn, ...
Stem cell research 12 (1), 194-208, 2014
Hyperinsulinemia in obesity, inflammation, and cancer
AMY Zhang, EA Wellberg, JL Kopp, JD Johnson
Diabetes & metabolism journal 45 (3), 285, 2021
Reduced circulating insulin enhances insulin sensitivity in old mice and extends lifespan
NM Templeman, S Flibotte, JHL Chik, S Sinha, GE Lim, LJ Foster, ...
Cell reports 20 (2), 451-463, 2017
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