Simpson Joseph
Simpson Joseph
Professor of Chemistry & Biochemistry, UC San Diego
Verified email at
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Electrostatics of nanosystems: application to microtubules and the ribosome
NA Baker, D Sept, S Joseph, MJ Holst, JA McCammon
Proceedings of the National Academy of Sciences 98 (18), 10037-10041, 2001
Simulating movement of tRNA into the ribosome during decoding
KY Sanbonmatsu, S Joseph, CS Tung
Proceedings of the National Academy of Sciences 102 (44), 15854-15859, 2005
Fragile X mental retardation protein regulates translation by binding directly to the ribosome
E Chen, MR Sharma, X Shi, RK Agrawal, S Joseph
Molecular cell 54 (3), 407-417, 2014
Essential nucleotide sequences and secondary structure elements of the hairpin ribozyme.
A Berzal‐Herranz, S Joseph, BM Chowrira, SE Butcher, JM Burke
The EMBO Journal 12 (6), 2567-2573, 1993
Unfolding of mRNA secondary structure by the bacterial translation initiation complex
SM Studer, S Joseph
Molecular cell 22 (1), 105-115, 2006
In vitro selection of active hairpin ribozymes by sequential RNA-catalyzed cleavage and ligation reactions.
A Berzal-Herranz, S Joseph, JM Burke
Genes & development 6 (1), 129-134, 1992
Optimization of an anti-HIV hairpin ribozyme by in vitro selection.
S Joseph, JM Burke
Journal of Biological Chemistry 268 (33), 24515-24518, 1993
Rapid kinetic analysis of EF-G-dependent mRNA translocation in the ribosome
SM Studer, JS Feinberg, S Joseph
Journal of molecular biology 327 (2), 369-381, 2003
Substrate selection rules for the hairpin ribozyme determined by in vitro selection, mutation, and analysis of mismatched substrates.
S Joseph, A Berzal-Herranz, BM Chowrira, SE Butcher, JM Burke
Genes & development 7 (1), 130-138, 1993
EF‐G‐catalyzed translocation of anticodon stem–loop analogs of transfer RNA in the ribosome
S Joseph, HF Noller
The EMBO Journal, 1998
Deletion of a conserved, central ribosomal intersubunit RNA bridge
IK Ali, L Lancaster, J Feinberg, S Joseph, HF Noller
Molecular cell 23 (6), 865-874, 2006
Functional role of the sarcin–ricin loop of the 23S rRNA in the elongation cycle of protein synthesis
X Shi, PK Khade, KY Sanbonmatsu, S Joseph
Journal of molecular biology 419 (3-4), 125-138, 2012
Identification of molecular interactions between P-site tRNA and the ribosome essential for translocation
JS Feinberg, S Joseph
Proceedings of the National Academy of Sciences 98 (20), 11120-11125, 2001
Mapping the inside of the ribosome with an RNA helical ruler
S Joseph, B Weiser, HF Noller
Science 278 (5340), 1093-1098, 1997
Mapping the rRNA neighborhood of the acceptor end of tRNA in the ribosome.
S Joseph, HF Noller
The EMBO Journal 15 (4), 910-916, 1996
M., and McCammon, J.(2001)
N Baker, D Sept, S Joseph, M Holst
Proc. Natl. Acad. Sci. USA 98, 10037-10041, 0
Structure and function of ribosomal RNA
HF Noller, R Green, G Heilek, V Hoffarth, A Hüttenhofer, S Joseph, I Lee, ...
Biochemistry and cell biology 73 (11-12), 997-1009, 1995
Modified nucleotides in tRNALys and tRNAVal are important for translocation
SS Phelps, A Malkiewicz, PF Agris, S Joseph
Journal of molecular biology 338 (3), 439-444, 2004
Fragile X mental retardation protein: A paradigm for translational control by RNA-binding proteins
E Chen, S Joseph
Biochimie 114, 147-154, 2015
Understanding discrimination by the ribosome: Stability testing and groove measurement of codon–anticodon pairs
KY Sanbonmatsu, S Joseph
Journal of molecular biology 328 (1), 33-47, 2003
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