Andrea LeBlanc
Andrea LeBlanc
Professor of Neuroscience, McGill U.
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Involvement of caspases in proteolytic cleavage of Alzheimer’s amyloid-β precursor protein and amyloidogenic Aβ peptide formation
FG Gervais, D Xu, GS Robertson, JP Vaillancourt, Y Zhu, JQ Huang, ...
Cell 97 (3), 395-406, 1999
Fatal familial insomnia and familial Creutzfeldt-Jakob disease: disease phenotype determined by a DNA polymorphism
LG Goldfarb, RB Petersen, M Tabaton, P Brown, AC LeBlanc, P Montagna, ...
Science 258 (5083), 806-808, 1992
Fatal familial insomnia, a prion disease with a mutation at codon 178 of the prion protein gene
R Medori, HJ Tritschler, A LeBlanc, F Villare, V Manetto, HY Chen, R Xue, ...
New England Journal of Medicine 326 (7), 444-449, 1992
Selective cytotoxicity of intracellular amyloid β peptide1–42 through p53 and Bax in cultured primary human neurons
Y Zhang, R McLaughlin, C Goodyer, A LeBlanc
The Journal of cell biology 156 (3), 519-529, 2002
Prion protein protects human neurons against Bax-mediated apoptosis
Y Bounhar, Y Zhang, CG Goodyer, A LeBlanc
Journal of Biological Chemistry 276 (42), 39145-39149, 2001
Amyloid β peptide of Alzheimer’s disease downregulates Bcl-2 and upregulates Bax expression in human neurons
E Paradis, H Douillard, M Koutroumanis, C Goodyer, A LeBlanc
Journal of Neuroscience 16 (23), 7533-7539, 1996
Testosterone‐mediated neuroprotection through the androgen receptor in human primary neurons
J Hammond, Q Le, C Goodyer, M Gelfand, M Trifiro, A LeBlanc
Journal of neurochemistry 77 (5), 1319-1326, 2001
Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease
A LeBlanc, H Liu, C Goodyer, C Bergeron, J Hammond
Journal of Biological Chemistry 274 (33), 23426-23436, 1999
Active caspase-6 and caspase-6-cleaved tau in neuropil threads, neuritic plaques, and neurofibrillary tangles of Alzheimer's disease
H Guo, S Albrecht, M Bourdeau, T Petzke, C Bergeron, AC LeBlanc
The American journal of pathology 165 (2), 523-531, 2004
Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation
V Kaushal, R Dye, P Pakavathkumar, B Foveau, J Flores, B Hyman, ...
Cell Death & Differentiation 22 (10), 1676-1686, 2015
Fatal familial insomnia: a second kindred with mutation of prion protein gene at codon 178
R Medori, P Montagna, HJ Tritschler, A LeBlanc, P Cortelli, P Tinuper, ...
Neurology 42 (3), 669-669, 1992
Neuroprotective functions of prion protein
X Roucou, M Gains, AC LeBlanc
Journal of neuroscience research 75 (2), 153-161, 2004
Cytosolic prion protein is not toxic and protects against Bax-mediated cell death in human primary neurons
X Roucou, Q Guo, Y Zhang, CG Goodyer, AC LeBlanc
Journal of Biological Chemistry 278 (42), 40877-40881, 2003
Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model
J Flores, A NoŽl, B Foveau, J Lynham, C Lecrux, AC LeBlanc
Nature communications 9 (1), 3916, 2018
Cellular prion protein neuroprotective function: implications in prion diseases
X Roucou, AC LeBlanc
Journal of molecular medicine 83, 3-11, 2005
Cellular prion protein inhibits proapoptotic Bax conformational change in human neurons and in breast carcinoma MCF-7 cells
X Roucou, PN Giannopoulos, Y Zhang, J Jodoin, CG Goodyer, A LeBlanc
Cell Death & Differentiation 12 (7), 783-795, 2005
Selective and protracted apoptosis in human primary neurons microinjected with active caspase-3,-6,-7, and-8
Y Zhang, C Goodyer, A LeBlanc
Journal of Neuroscience 20 (22), 8384-8389, 2000
Activation of caspase-6 in aging and mild cognitive impairment
S Albrecht, M Bourdeau, D Bennett, EJ Mufson, M Bhattacharjee, ...
The American journal of pathology 170 (4), 1200-1209, 2007
Increased production of 4 kDa amyloid beta peptide in serum deprived human primary neuron cultures: possible involvement of apoptosis
A LeBlanc
Journal of Neuroscience 15 (12), 7837-7846, 1995
Estrogen and androgen protection of human neurons against intracellular amyloid β1-42 toxicity through heat shock protein 70
Y Zhang, N Champagne, LK Beitel, CG Goodyer, M Trifiro, A LeBlanc
Journal of Neuroscience 24 (23), 5315-5321, 2004
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