Michael P Hughes
Michael P Hughes
Postdoctoral Scholar, St. Jude Research Hospital
Verified email at
Cited by
Cited by
Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks
MP Hughes, MR Sawaya, DR Boyer, L Goldschmidt, JA Rodriguez, ...
Science 359 (6376), 698-701, 2018
Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation
EL Guenther, Q Cao, H Trinh, J Lu, MR Sawaya, D Cascio, DR Boyer, ...
Nature structural & molecular biology 25 (6), 463-471, 2018
The expanding amyloid family: Structure, stability, function, and pathogenesis
MR Sawaya, MP Hughes, JA Rodriguez, R Riek, DS Eisenberg
Cell 184 (19), 4857-4873, 2021
TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle
TO Vogler, JR Wheeler, ED Nguyen, MP Hughes, KA Britson, E Lester, ...
Nature 563 (7732), 508-513, 2018
Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta
L Jiang, C Liu, D Leibly, M Landau, M Zhao, MP Hughes, DS Eisenberg
Elife 2, e00857, 2013
The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure
DR Boyer, B Li, C Sun, W Fan, K Zhou, MP Hughes, MR Sawaya, L Jiang, ...
Proceedings of the National Academy of Sciences 117 (7), 3592-3602, 2020
Graft weight/recipient weight ratio: how well does it predict outcome after partial liver transplants?
MJ Hill, M Hughes, T Jie, M Cohen, J Lake, WD Payne, A Humar
Liver Transplantation 15 (9), 1056-1062, 2009
CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid
J Lu, Q Cao, MP Hughes, MR Sawaya, DR Boyer, D Cascio, ...
Nature communications 11 (1), 4090, 2020
Sexuality and cancer: How oncology nurses can address it BETTER
J Mick, M Hughes, M Cohen
Oncol Nurs Forum 30 (2), 152-153, 2003
Prevalence and species distribution of the low-complexity, amyloid-like, reversible, kinked segment structural motif in amyloid-like fibrils
MP Hughes, L Goldschmidt, DS Eisenberg
Journal of Biological Chemistry 297 (4), 2021
The dynomak: An advanced spheromak reactor concept with imposed-dynamo current drive and next-generation nuclear power technologies
DA Sutherland, TR Jarboe, KD Morgan, M Pfaff, ES Lavine, Y Kamikawa, ...
Fusion Engineering and Design 89 (4), 412-425, 2014
Atomic structures of corkscrew‐forming segments of SOD1 reveal varied oligomer conformations
S Sangwan, MR Sawaya, KA Murray, MP Hughes, DS Eisenberg
Protein Science 27 (7), 1231-1242, 2018
Multimodal surveillance of SARS-CoV-2 at a university enables development of a robust outbreak response framework
BA Petros, JS Paull, CH Tomkins-Tinch, BC Loftness, KC DeRuff, P Nair, ...
Med 3 (12), 883-900. e13, 2022
Extended β-strands contribute to reversible amyloid formation
KA Murray, D Evans, MP Hughes, MR Sawaya, CJ Hu, KN Houk, ...
ACS nano 16 (2), 2154-2163, 2022
Identifying amyloid-related diseases by mapping mutations in low-complexity protein domains to pathologies
KA Murray, MP Hughes, CJ Hu, MR Sawaya, L Salwinski, H Pan, ...
Nature structural & molecular biology 29 (6), 529-536, 2022
DNA facilitates oligomerization and prevents aggregation via DNA networks
TJ Litberg, B Docter, MP Hughes, J Bourne, S Horowitz
Biophysical Journal 118 (1), 162-171, 2020
Hydroxychloroquine for treatment of non‐hospitalized adults with COVID‐19: A meta‐analysis of individual participant data of randomized trials
O Mitjā, G Reis, DR Boulware, AM Spivak, A Sarwar, C Johnston, B Webb, ...
Clinical and translational science 16 (3), 524-535, 2023
A spatiotemporal reconstruction of the C. elegans pharyngeal cuticle reveals a structure rich in phase-separating proteins
M Kamal, L Tokmakjian, J Knox, P Mastrangelo, J Ji, H Cai, ...
Elife 11, e79396, 2022
Bioinformatic identification of previously unrecognized amyloidogenic proteins
GM Rosenberg, KA Murray, L Salwinski, MP Hughes, R Abskharon, ...
Journal of Biological Chemistry 298 (5), 2022
The case for altruism in institutional diagnostic testing
I Specht, K Sani, Y Botti-Lodovico, M Hughes, K Heumann, A Bronson, ...
Scientific Reports 12 (1), 1857, 2022
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