| Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks MP Hughes, MR Sawaya, DR Boyer, L Goldschmidt, JA Rodriguez, ... Science 359 (6376), 698-701, 2018 | 337 | 2018 |
| Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation EL Guenther, Q Cao, H Trinh, J Lu, MR Sawaya, D Cascio, DR Boyer, ... Nature structural & molecular biology 25 (6), 463-471, 2018 | 174 | 2018 |
| TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle TO Vogler, JR Wheeler, ED Nguyen, MP Hughes, KA Britson, E Lester, ... Nature 563 (7732), 508-513, 2018 | 157 | 2018 |
| Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta L Jiang, C Liu, D Leibly, M Landau, M Zhao, MP Hughes, DS Eisenberg Elife 2, e00857, 2013 | 142 | 2013 |
| The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure DR Boyer, B Li, C Sun, W Fan, K Zhou, MP Hughes, MR Sawaya, L Jiang, ... Proceedings of the National Academy of Sciences 117 (7), 3592-3602, 2020 | 107 | 2020 |
| The expanding amyloid family: Structure, stability, function, and pathogenesis MR Sawaya, MP Hughes, JA Rodriguez, R Riek, DS Eisenberg Cell 184 (19), 4857-4873, 2021 | 86 | 2021 |
| CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid J Lu, Q Cao, MP Hughes, MR Sawaya, DR Boyer, D Cascio, ... Nature communications 11 (1), 4090, 2020 | 62 | 2020 |
| Prevalence and species distribution of the low-complexity, amyloid-like, reversible, kinked segment structural motif in amyloid-like fibrils MP Hughes, L Goldschmidt, DS Eisenberg Journal of Biological Chemistry 297 (4), 2021 | 18 | 2021 |
| Atomic structures of corkscrew‐forming segments of SOD1 reveal varied oligomer conformations S Sangwan, MR Sawaya, KA Murray, MP Hughes, DS Eisenberg Protein Science 27 (7), 1231-1242, 2018 | 16 | 2018 |
| DNA facilitates oligomerization and prevents aggregation via DNA networks TJ Litberg, B Docter, MP Hughes, J Bourne, S Horowitz Biophysical journal 118 (1), 162-171, 2020 | 12 | 2020 |
| Extended β-strands contribute to reversible amyloid formation KA Murray, D Evans, MP Hughes, MR Sawaya, CJ Hu, KN Houk, ... ACS nano 16 (2), 2154-2163, 2022 | 7 | 2022 |
| Identifying amyloid-related diseases by mapping mutations in low-complexity protein domains to pathologies KA Murray, MP Hughes, CJ Hu, MR Sawaya, L Salwinski, H Pan, ... Nature Structural & Molecular Biology 29 (6), 529-536, 2022 | 5 | 2022 |
| Bioinformatic identification of previously unrecognized amyloidogenic proteins GM Rosenberg, KA Murray, L Salwinski, MP Hughes, R Abskharon, ... Journal of Biological Chemistry 298 (5), 2022 | 2 | 2022 |
| The prevalence and distribution in genomes of low-complexity, amyloid-like, reversible, kinked segment (LARKS), a common structural motif in amyloid-like fibrils MP Hughes, L Goldschmidt, DS Eisenberg BioRxiv, 2020.12. 08.415679, 2020 | 2 | 2020 |
| Low-complexity domains adhere by reversible amyloid-like interactions between kinked β-sheets MP Hughes, MR Sawaya, L Goldschmidt, JA Rodriguez, D Cascio, ... bioRxiv, 153817, 2017 | 2 | 2017 |
| A spatiotemporal reconstruction of the C. elegans pharyngeal cuticle reveals a structure rich in phase-separating proteins M Kamal, L Tokmakjian, J Knox, P Mastrangelo, J Ji, H Cai, ... Elife 11, e79396, 2022 | 1 | 2022 |
| The cryoEM structure of the fibril-forming low-complexity domain of hnRNPA2 reveals distinct differences from pathogenic amyloid and shows how mutation converts it to the … J Lu, Q Cao, MP Hughes, MR Sawaya, DR Boyer, D Cascio, ... bioRxiv, 2020.05. 24.113621, 2020 | 1 | 2020 |
| Correction: Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta L Jiang, C Liu, D Leibly, M Landau, M Zhao, MP Hughes, DS Eisenberg Elife 2, e01252, 2013 | 1 | 2013 |
| A spatiotemporal reconstruction of the C. elegans pharyngeal cuticle reveals a structure rich in phase-separating proteins K Muntasir, T Levon, J Knox, P Mastrangelo, J Jingxiu, C Hao, ... eLife 11, 2022 | | 2022 |
| Author Correction: Atomic Structures of Segments from TDP-43 LCD and insight into Reversible and Pathogenic Aggregation EL Guenther, Q Cao, H Trinh, J Lu, MR Sawaya, D Cascio, DR Boyer, ... Nature structural & molecular biology 26 (10), 988, 2019 | | 2019 |
David S. EisenbergPaul Boyer Professor, HHMI-UCLAVerified email at mbi.ucla.edu
