Zuoshang Xu
Zuoshang Xu
Professor of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School
Verified email at - Homepage
Cited by
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Asymmetry in the assembly of the RNAi enzyme complex
DS Schwarz, G Hutvágner, T Du, Z Xu, N Aronin, PD Zamore
Cell 115 (2), 199-208, 2003
Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1
J Kong, Z Xu
Journal of Neuroscience 18 (9), 3241-3250, 1998
Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity.
DR Borchelt, MK Lee, HS Slunt, M Guarnieri, ZS Xu, PC Wong, ...
Proceedings of the National Academy of Sciences 91 (17), 8292-8296, 1994
Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease
Z Xu, LC Cork, JW Griffin, DW Cleveland
Cell 73 (1), 23-33, 1993
Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis
CH Wu, C Fallini, N Ticozzi, PJ Keagle, PC Sapp, K Piotrowska, P Lowe, ...
Nature 488 (7412), 499-503, 2012
Neurofilaments are obligate heteropolymers in vivo
MK Lee, Z Xu, PC Wong, DW Cleveland
The Journal of cell biology 122 (6), 1337-1350, 1993
Superoxide dismutase is an abundant component in cell bodies, dendrites, and axons of motor neurons and in a subset of other neurons.
CA Pardo, Z Xu, DR Borchelt, DL Price, SS Sisodia, DW Cleveland
Proceedings of the National Academy of Sciences 92 (4), 954-958, 1995
Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model
H Kikuchi, G Almer, S Yamashita, C Guégan, M Nagai, Z Xu, AA Sosunov, ...
Proceedings of the National Academy of Sciences 103 (15), 6025-6030, 2006
Designing siRNA that distinguish between genes that differ by a single nucleotide
DS Schwarz, H Ding, L Kennington, JT Moore, J Schelter, J Burchard, ...
PLoS genetics 2 (9), e140, 2006
Several rAAV vectors efficiently cross the blood–brain barrier and transduce neurons and astrocytes in the neonatal mouse central nervous system
H Zhang, B Yang, X Mu, SS Ahmed, Q Su, R He, H Wang, C Mueller, ...
Molecular Therapy 19 (8), 1440-1448, 2011
Reactive astrocytes secrete lcn2 to promote neuron death
F Bi, C Huang, J Tong, G Qiu, B Huang, Q Wu, F Li, Z Xu, R Bowser, ...
Proceedings of the National Academy of Sciences 110 (10), 4069-4074, 2013
ALS-associated mutant SOD1G93A causes mitochondrial vacuolation by expansion of the intermembrane space and by involvement of SOD1 aggregation and …
CMJ Higgins, C Jung, Z Xu
BMC neuroscience 4, 1-14, 2003
Mutant Cu, Zn superoxide dismutase that causes motoneuron degeneration is present in mitochondria in the CNS
CMJ Higgins, C Jung, H Ding, Z Xu
Regional modulation of neurofilament organization by myelination in normal axons
ST Hsieh, GJ Kidd, TO Crawford, Z Xu, WM Lin, BD Trapp, DW Cleveland, ...
Journal of Neuroscience 14 (11), 6392-6401, 1994
Glycosylation of mammalian neurofilaments. Localization of multiple O-linked N-acetylglucosamine moieties on neurofilament polypeptides L and M
DL Dong, ZS Xu, MR Chevrier, RJ Cotter, DW Cleveland, GW Hart
Journal of Biological Chemistry 268 (22), 16679-16687, 1993
Mitochondrial electron transport chain complex dysfunction in a transgenic mouse model for amyotrophic lateral sclerosis
C Jung, CMJ Higgins, Z Xu
Journal of neurochemistry 83 (3), 535-545, 2002
Allele-specific RNA interference
Z Xu, P Zamore
US Patent App. 10/700,816, 2004
Mitochondrial dysfunction and its role in motor neuron degeneration in ALS
G Manfredi, Z Xu
Mitochondrion 5 (2), 77-87, 2005
Global CNS transduction of adult mice by intravenously delivered rAAVrh. 8 and rAAVrh. 10 and nonhuman primates by rAAVrh. 10
B Yang, S Li, H Wang, Y Guo, DJ Gessler, C Cao, Q Su, J Kramer, ...
Molecular Therapy 22 (7), 1299-1309, 2014
An RNA polymerase II construct synthesizes short-hairpin RNA with a quantitative indicator and mediates highly efficient RNAi
H Zhou, XG Xia, Z Xu
Nucleic acids research 33 (6), e62-e62, 2005
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