| Comparative in vivo stability of copper-64-labeled cross-bridged and conventional tetraazamacrocyclic complexes CA Boswell, X Sun, W Niu, GR Weisman, EH Wong, AL Rheingold, ... Journal of medicinal chemistry 47 (6), 1465-1474, 2004 | 583 | 2004 |
| Effects of charge on antibody tissue distribution and pharmacokinetics CA Boswell, DB Tesar, K Mukhyala, FP Theil, PJ Fielder, LA Khawli Bioconjugate chemistry 21 (12), 2153-2163, 2010 | 412 | 2010 |
| Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants N Bien-Ly, YJ Yu, D Bumbaca, J Elstrott, CA Boswell, Y Zhang, W Luk, ... Journal of Experimental Medicine 211 (2), 233-244, 2014 | 324 | 2014 |
| Development of radioimmunotherapeutic and diagnostic antibodies: an inside-out view CA Boswell, MW Brechbiel Nuclear medicine and biology 34 (7), 757-778, 2007 | 300 | 2007 |
| Radiolabeling and in vivo behavior of copper-64-labeled cross-bridged cyclam ligands X Sun, M Wuest, GR Weisman, EH Wong, DP Reed, CA Boswell, ... Journal of medicinal chemistry 45 (2), 469-477, 2002 | 300 | 2002 |
| Impact of drug conjugation on pharmacokinetics and tissue distribution of anti-STEAP1 antibody–drug conjugates in rats CA Boswell, EE Mundo, C Zhang, D Bumbaca, NR Valle, KR Kozak, ... Bioconjugate chemistry 22 (10), 1994-2004, 2011 | 225 | 2011 |
| Lack of widespread BBB disruption in Alzheimer’s disease models: focus on therapeutic antibodies N Bien-Ly, CA Boswell, S Jeet, TG Beach, K Hoyte, W Luk, V Shihadeh, ... Neuron 88 (2), 289-297, 2015 | 189 | 2015 |
| Preclinical pharmacokinetics, pharmacodynamics, tissue distribution, and tumor penetration of anti-PD-L1 monoclonal antibody, an immune checkpoint inhibitor R Deng, D Bumbaca, CV Pastuskovas, CA Boswell, D West, KJ Cowan, ... MAbs 8 (3), 593-603, 2016 | 184 | 2016 |
| Synthesis, Characterization, and Biological Evaluation of Integrin αvβ3-Targeted PAMAM Dendrimers CA Boswell, PK Eck, CAS Regino, M Bernardo, KJ Wong, DE Milenic, ... Molecular pharmaceutics 5 (4), 527-539, 2008 | 171 | 2008 |
| Kinetic Inertness and Electrochemical Behavior of Copper(II) Tetraazamacrocyclic Complexes: Possible Implications for in Vivo Stability KS Woodin, KJ Heroux, CA Boswell, EH Wong, GR Weisman, W Niu, ... European Journal of Inorganic Chemistry 2005 (23), 4829-4833, 2005 | 171 | 2005 |
| Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration Y Zheng, DB Tesar, L Benincosa, H Birnböck, CA Boswell, D Bumbaca, ... MAbs 4 (2), 243-255, 2012 | 129 | 2012 |
| Effects of anti-VEGF on pharmacokinetics, biodistribution, and tumor penetration of trastuzumab in a preclinical breast cancer model CV Pastuskovas, EE Mundo, SP Williams, TK Nayak, J Ho, S Ulufatu, ... Molecular cancer therapeutics 11 (3), 752-762, 2012 | 123 | 2012 |
| Relative target affinities of T-cell–dependent bispecific antibodies determine biodistribution in a solid tumor mouse model D Mandikian, N Takahashi, AA Lo, J Li, J Eastham-Anderson, D Slaga, ... Molecular cancer therapeutics 17 (4), 776-785, 2018 | 122 | 2018 |
| Physiochemical and biochemical factors influencing the pharmacokinetics of antibody therapeutics D Bumbaca, CA Boswell, PJ Fielder, LA Khawli The AAPS journal 14, 554-558, 2012 | 122 | 2012 |
| Framework selection can influence pharmacokinetics of a humanized therapeutic antibody through differences in molecule charge B Li, D Tesar, CA Boswell, HS Cahaya, A Wong, J Zhang, YG Meng, ... MAbs 6 (5), 1255-1264, 2014 | 120 | 2014 |
| Synthesis of a Cross-Bridged Cyclam Derivative for Peptide Conjugation and 64Cu Radiolabeling CA Boswell, CAS Regino, KE Baidoo, KJ Wong, A Bumb, H Xu, ... Bioconjugate chemistry 19 (7), 1476-1484, 2008 | 92 | 2008 |
| Design, synthesis, and characterization of a dual modality positron emission tomography and fluorescence imaging agent for monoclonal antibody tumor-targeted imaging H Xu, K Baidoo, AJ Gunn, CA Boswell, DE Milenic, PL Choyke, ... Journal of medicinal chemistry 50 (19), 4759-4765, 2007 | 83 | 2007 |
| Quantitative cumulative biodistribution of antibodies in mice: effect of modulating binding affinity to the neonatal Fc receptor V Yip, E Palma, DB Tesar, EE Mundo, D Bumbaca, EK Torres, NA Reyes, ... MAbs 6 (3), 689-696, 2014 | 77 | 2014 |
| Auger electrons: lethal, low energy, and coming soon to a tumor cell nucleus near you CA Boswell, MW Brechbiel Journal of Nuclear Medicine 46 (12), 1946-1947, 2005 | 75 | 2005 |
| Evaluating the use of antibody variable region (Fv) charge as a risk assessment tool for predicting typical cynomolgus monkey pharmacokinetics DB Yadav, VK Sharma, CA Boswell, I Hotzel, D Tesar, Y Shang, Y Ying, ... Journal of Biological Chemistry 290 (50), 29732-29741, 2015 | 74 | 2015 |
Leslie KhawliProfessor of Pathology, Keck School of Medicine of the University of Southern CaliforniaVerified email at usc.edu
