Tim Downing
Tim Downing
Head of Genomics, Pirbright Institute, UK
Verified email at - Homepage
Cited by
Cited by
Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance
T Downing, H Imamura, S Decuypere, TG Clark, GH Coombs, JA Cotton, ...
Genome research 21 (12), 2143-2156, 2011
Leishmania infections: Molecular targets and diagnosis
M Akhoundi, T Downing, J Votępka, K Kuhls, J Lukeš, A Cannet, C Ravel, ...
Molecular aspects of medicine 57, 1-29, 2017
Genomic Confirmation of Hybridisation and Recent Inbreeding in a Vector-Isolated Leishmania Population
MB Rogers, T Downing, BA Smith, H Imamura, M Sanders, M Svobodova, ...
PLoS genetics 10 (1), e1004092, 2014
Evolutionary genomics of epidemic visceral leishmaniasis in the Indian subcontinent
H Imamura, T Downing, F Van den Broeck, MJ Sanders, S Rijal, S Sundar, ...
Elife 5, e12613, 2016
Adaptive mechanisms in pathogens: universal aneuploidy in Leishmania
A Mannaert, T Downing, H Imamura, JC Dujardin
Trends in Parasitology, 2012
The avian Toll-Like receptor pathway—Subtle differences amidst general conformity
P Cormican, AT Lloyd, T Downing, SJ Connell, D Bradley, C O’Farrelly
Developmental & Comparative Immunology 33 (9), 967-973, 2009
Global genome diversity of the Leishmania donovani complex
SU Franssen, C Durrant, O Stark, B Moser, T Downing, H Imamura, ...
Elife 9, e51243, 2020
Development and evaluation of a novel loop-mediated isothermal amplification assay for diagnosis of cutaneous and visceral leishmaniasis
ER Adams, G Schoone, I Versteeg, MA Gomez, E Diro, Y Mori, D Perlee, ...
Journal of Clinical Microbiology 56 (7), 10.1128/jcm. 00386-18, 2018
The differential evolutionary dynamics of avian cytokine and TLR gene classes
T Downing, AT Lloyd, C O’Farrelly, DG Bradley
The Journal of Immunology 184 (12), 6993-7000, 2010
In vitro selection of miltefosine resistance in promastigotes of Leishmania donovani from Nepal: genomic and metabolomic characterization
CD Shaw, J Lonchamp, T Downing, H Imamura, TM Freeman, JA Cotton, ...
Molecular Microbiology 99 (6), 1134-1148, 2016
An Escherichia coli ST131 pangenome atlas reveals population structure and evolution across 4,071 isolates
AG Decano, T Downing
Scientific reports 9 (1), 17394, 2019
Genome-wide SNP and microsatellite variation illuminate population-level epidemiology in the Leishmania donovani species complex
T Downing, O Stark, M Vanaerschot, H Imamura, M Sanders, ...
Infection, Genetics and Evolution, 2011
The triploid East African Highland Banana (EAHB) genepool is genetically uniform arising from a single ancestral clone that underwent population expansion by vegetative propagation
M Kitavi, T Downing, J Lorenzen, D Karamura, M Onyango, M Nyine, ...
Theoretical and Applied Genetics 129, 547-561, 2016
Genomic surveillance of Escherichia coli ST131 identifies local expansion and serial replacement of subclones
C Ludden, AG Decano, D Jamrozy, D Pickard, D Morris, J Parkhill, ...
Microbial Genomics 6 (4), 2020
The genome of Leishmania adleri from a mammalian host highlights chromosome fission in Sauroleishmania
S Coughlan, P Mulhair, M Sanders, G Schonian, JA Cotton, T Downing
Scientific reports 7 (1), 43747, 2017
Leishmania naiffi and Leishmania guyanensis reference genomes highlight genome structure and gene evolution in the Viannia subgenus
S Coughlan, AS Taylor, E Feane, M Sanders, G Schonian, JA Cotton, ...
Royal Society open science 5 (4), 172212, 2018
Redeploying β-lactam antibiotics as a novel antivirulence strategy for the treatment of methicillin-resistant Staphylococcus aureus infections
EM Waters, JK Rudkin, S Coughlan, GC Clair, JN Adkins, S Gore, G Xia, ...
The Journal of infectious diseases 215 (1), 80-87, 2017
Tackling Drug Resistant Infection Outbreaks of Global Pandemic Escherichia coli ST131 Using Evolutionary and Epidemiological Genomics
T Downing
Microorganisms 3 (2), 236-267, 2015
Genetic Markers for SSG Resistance in Leishmania donovani and SSG Treatment Failure in Visceral Leishmaniasis Patients of the Indian Subcontinent
M Vanaerschot, S Decuypere, T Downing, H Imamura, O Stark, ...
The Journal of infectious diseases 206 (5), 752-755, 2012
Complete assembly of Escherichia coli sequence type 131 genomes using long reads demonstrates antibiotic resistance gene variation within diverse plasmid and chromosomal contexts
AG Decano, C Ludden, T Feltwell, K Judge, J Parkhill, T Downing
Msphere 4 (3), 10.1128/msphere. 00130-19, 2019
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