| Kemp elimination catalysts by computational enzyme design D Röthlisberger, O Khersonsky, AM Wollacott, L Jiang, J DeChancie, ... Nature 453 (7192), 190-195, 2008 | 1575 | 2008 |
| De novo computational design of retro-aldol enzymes L Jiang, EA Althoff, FR Clemente, L Doyle, D Rothlisberger, A Zanghellini, ... science 319 (5868), 1387-1391, 2008 | 1440 | 2008 |
| Structure of the toxic core of α-synuclein from invisible crystals JA Rodriguez, MI Ivanova, MR Sawaya, D Cascio, FE Reyes, D Shi, ... Nature 525 (7570), 486-490, 2015 | 644 | 2015 |
| Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel B Li, P Ge, KA Murray, P Sheth, M Zhang, G Nair, MR Sawaya, WS Shin, ... Nature communications 9 (1), 3609, 2018 | 597 | 2018 |
| Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation SA Sievers, J Karanicolas, HW Chang, A Zhao, L Jiang, O Zirafi, ... Nature 475 (7354), 96-100, 2011 | 535 | 2011 |
| New algorithms and an in silico benchmark for computational enzyme design A Zanghellini, L Jiang, AM Wollacott, G Cheng, J Meiler, EA Althoff, ... Protein Science 15 (12), 2785-2794, 2006 | 483 | 2006 |
| A designed inhibitor of p53 aggregation rescues p53 tumor suppression in ovarian carcinomas A Soragni, DM Janzen, LM Johnson, AG Lindgren, ATQ Nguyen, ... Cancer cell 29 (1), 90-103, 2016 | 363 | 2016 |
| CH··· O Hydrogen Bonds at Protein-Protein Interfaces* 210 L Jiang, L Lai Journal of Biological Chemistry 277 (40), 37732-37740, 2002 | 273 | 2002 |
| Towards a pharmacophore for amyloid M Landau, MR Sawaya, KF Faull, A Laganowsky, L Jiang, SA Sievers, ... PLoS biology 9 (6), e1001080, 2011 | 244 | 2011 |
| Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates C Liu, M Zhao, L Jiang, PN Cheng, J Park, MR Sawaya, A Pensalfini, ... Proceedings of the National Academy of Sciences 109 (51), 20913-20918, 2012 | 211 | 2012 |
| Robust design and optimization of retroaldol enzymes EA Althoff, L Wang, L Jiang, L Giger, JK Lassila, Z Wang, M Smith, S Hari, ... Protein science 21 (5), 717-726, 2012 | 200 | 2012 |
| Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly X Gui, F Luo, Y Li, H Zhou, Z Qin, Z Liu, J Gu, M Xie, K Zhao, B Dai, ... Nature communications 10 (1), 2006, 2019 | 189 | 2019 |
| A “solvated rotamer” approach to modeling water‐mediated hydrogen bonds at protein–protein interfaces L Jiang, B Kuhlman, T Kortemme, D Baker PROTEINS: structure, function, and bioinformatics 58 (4), 893-904, 2005 | 167 | 2005 |
| Structures of fibrils formed by α-synuclein hereditary disease mutant H50Q reveal new polymorphs DR Boyer, B Li, C Sun, W Fan, MR Sawaya, L Jiang, DS Eisenberg Nature structural & molecular biology 26 (11), 1044-1052, 2019 | 162 | 2019 |
| Uncovering the mechanism of aggregation of human transthyretin L Saelices, LM Johnson, WY Liang, MR Sawaya, D Cascio, P Ruchala, ... Journal of Biological Chemistry 290 (48), 28932-28943, 2015 | 161 | 2015 |
| The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure DR Boyer, B Li, C Sun, W Fan, K Zhou, MP Hughes, MR Sawaya, L Jiang, ... Proceedings of the National Academy of Sciences 117 (7), 3592-3602, 2020 | 158 | 2020 |
| Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta L Jiang, C Liu, D Leibly, M Landau, M Zhao, MP Hughes, DS Eisenberg Elife 2, e00857, 2013 | 155 | 2013 |
| Potential of mean force for protein–protein interaction studies L Jiang, Y Gao, F Mao, Z Liu, L Lai Proteins: Structure, Function, and Bioinformatics 46 (2), 190-196, 2002 | 149 | 2002 |
| NELL-1 in the treatment of osteoporotic bone loss AW James, J Shen, X Zhang, G Asatrian, R Goyal, JH Kwak, L Jiang, ... Nature communications 6 (1), 7362, 2015 | 130 | 2015 |
| Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity P Krotee, JA Rodriguez, MR Sawaya, D Cascio, FE Reyes, D Shi, ... Elife 6, e19273, 2017 | 109 | 2017 |
Cong LiuInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic ChemistryVerified email at sioc.ac.cn
