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Lin Jiang
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Kemp elimination catalysts by computational enzyme design
D Röthlisberger, O Khersonsky, AM Wollacott, L Jiang, J DeChancie, ...
Nature 453 (7192), 190-195, 2008
15322008
De novo computational design of retro-aldol enzymes
L Jiang, EA Althoff, FR Clemente, L Doyle, D Rothlisberger, A Zanghellini, ...
science 319 (5868), 1387-1391, 2008
14112008
Structure of the toxic core of α-synuclein from invisible crystals
JA Rodriguez, MI Ivanova, MR Sawaya, D Cascio, FE Reyes, D Shi, ...
Nature 525 (7570), 486-490, 2015
6182015
Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel
B Li, P Ge, KA Murray, P Sheth, M Zhang, G Nair, MR Sawaya, WS Shin, ...
Nature communications 9 (1), 3609, 2018
5602018
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
SA Sievers, J Karanicolas, HW Chang, A Zhao, L Jiang, O Zirafi, ...
Nature 475 (7354), 96-100, 2011
5222011
New algorithms and an in silico benchmark for computational enzyme design
A Zanghellini, L Jiang, AM Wollacott, G Cheng, J Meiler, EA Althoff, ...
Protein Science 15 (12), 2785-2794, 2006
4742006
A designed inhibitor of p53 aggregation rescues p53 tumor suppression in ovarian carcinomas
A Soragni, DM Janzen, LM Johnson, AG Lindgren, ATQ Nguyen, ...
Cancer cell 29 (1), 90-103, 2016
3372016
CH··· O Hydrogen Bonds at Protein-Protein Interfaces* 210
L Jiang, L Lai
Journal of Biological Chemistry 277 (40), 37732-37740, 2002
2712002
Towards a pharmacophore for amyloid
M Landau, MR Sawaya, KF Faull, A Laganowsky, L Jiang, SA Sievers, ...
PLoS biology 9 (6), e1001080, 2011
2412011
Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates
C Liu, M Zhao, L Jiang, PN Cheng, J Park, MR Sawaya, A Pensalfini, ...
Proceedings of the National Academy of Sciences 109 (51), 20913-20918, 2012
2082012
Robust design and optimization of retroaldol enzymes
EA Althoff, L Wang, L Jiang, L Giger, JK Lassila, Z Wang, M Smith, S Hari, ...
Protein science 21 (5), 717-726, 2012
1942012
Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly
X Gui, F Luo, Y Li, H Zhou, Z Qin, Z Liu, J Gu, M Xie, K Zhao, B Dai, ...
Nature communications 10 (1), 2006, 2019
1722019
A “solvated rotamer” approach to modeling water‐mediated hydrogen bonds at protein–protein interfaces
L Jiang, B Kuhlman, T Kortemme, D Baker
PROTEINS: structure, function, and bioinformatics 58 (4), 893-904, 2005
1662005
Uncovering the mechanism of aggregation of human transthyretin
L Saelices, LM Johnson, WY Liang, MR Sawaya, D Cascio, P Ruchala, ...
Journal of Biological Chemistry 290 (48), 28932-28943, 2015
1592015
Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta
L Jiang, C Liu, D Leibly, M Landau, M Zhao, MP Hughes, DS Eisenberg
Elife 2, e00857, 2013
1542013
Potential of mean force for protein–protein interaction studies
L Jiang, Y Gao, F Mao, Z Liu, L Lai
Proteins: Structure, Function, and Bioinformatics 46 (2), 190-196, 2002
1482002
Structures of fibrils formed by α-synuclein hereditary disease mutant H50Q reveal new polymorphs
DR Boyer, B Li, C Sun, W Fan, MR Sawaya, L Jiang, DS Eisenberg
Nature structural & molecular biology 26 (11), 1044-1052, 2019
1472019
The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure
DR Boyer, B Li, C Sun, W Fan, K Zhou, MP Hughes, MR Sawaya, L Jiang, ...
Proceedings of the National Academy of Sciences 117 (7), 3592-3602, 2020
1462020
NELL-1 in the treatment of osteoporotic bone loss
AW James, J Shen, X Zhang, G Asatrian, R Goyal, JH Kwak, L Jiang, ...
Nature communications 6 (1), 7362, 2015
1242015
Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity
P Krotee, JA Rodriguez, MR Sawaya, D Cascio, FE Reyes, D Shi, ...
Elife 6, e19273, 2017
1052017
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