|The anaplastic lymphoma kinase in the pathogenesis of cancer|
R Chiarle, C Voena, C Ambrogio, R Piva, G Inghirami
Nature Reviews Cancer 8 (1), 11-23, 2008
|Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target|
R Chiarle, WJ Simmons, H Cai, G Dhall, A Zamo, R Raz, JG Karras, ...
Nature medicine 11 (6), 623-629, 2005
|Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing|
N Crosetto, A Mitra, MJ Silva, M Bienko, N Dojer, Q Wang, E Karaca, ...
Nature methods 10 (4), 361-365, 2013
|Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells|
R Chiarle, Y Zhang, RL Frock, SM Lewis, B Molinie, YJ Ho, DR Myers, ...
Cell 147 (1), 107-119, 2011
|Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death|
A Zamo, R Chiarle, R Piva, J Howes, Y Fan, M Chilosi, DE Levy, ...
Oncogene 21 (7), 1038-1047, 2002
|Role of the F-box protein Skp2 in lymphomagenesis|
E Latres, R Chiarle, BA Schulman, NP Pavletich, A Pellicer, G Inghirami, ...
Proceedings of the National Academy of Sciences 98 (5), 2515-2520, 2001
|The BRAF pseudogene functions as a competitive endogenous RNA and induces lymphoma in vivo|
FA Karreth, M Reschke, A Ruocco, C Ng, B Chapuy, V Léopold, ...
Cell 161 (2), 319-332, 2015
|NPM-ALK transgenic mice spontaneously develop T-cell lymphomas and plasma cell tumors|
R Chiarle, JZ Gong, I Guasparri, A Pesci, J Cai, J Liu, WJ Simmons, ...
Blood, The Journal of the American Society of Hematology 101 (5), 1919-1927, 2003
|The STAT3 isoforms α and β have unique and specific functions|
D Maritano, ML Sugrue, S Tininini, S Dewilde, B Strobl, XP Fu, ...
Nature immunology 5 (4), 401-409, 2004
|Increased proteasome degradation of cyclin-dependent kinase inhibitor p27 is associated with a decreased overall survival in mantle cell lymphoma|
R Chiarle, LM Budel, J Skolnik, G Frizzera, M Chilosi, A Corato, G Pizzolo, ...
Blood, The Journal of the American Society of Hematology 95 (2), 619-626, 2000
|FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas|
S Duan, L Cermak, JK Pagan, M Rossi, C Martinengo, PF Di Celle, ...
Nature 481 (7379), 90-93, 2012
|Substitutions at codon 22 of Alzheimer's Aβ peptide induce diverse conformational changes and apoptotic effects in human cerebral endothelial cells|
L Miravalle, T Tokuda, R Chiarle, G Giaccone, O Bugiani, F Tagliavini, ...
Journal of Biological Chemistry 275 (35), 27110-27116, 2000
|KRAS dimerization impacts MEK inhibitor sensitivity and oncogenic activity of mutant KRAS|
C Ambrogio, J Köhler, ZW Zhou, H Wang, R Paranal, J Li, M Capelletti, ...
Cell 172 (4), 857-868. e15, 2018
|Simple and rapid in vivo generation of chromosomal rearrangements using CRISPR/Cas9 technology|
RB Blasco, E Karaca, C Ambrogio, TC Cheong, E Karayol, VG Minero, ...
Cell reports 9 (4), 1219-1227, 2014
|CD30 in normal and neoplastic cells|
R Chiarle, A Podda, G Prolla, J Gong, GJ Thorbecke, G Inghirami
Clinical immunology 90 (2), 157-164, 1999
|Mechanisms that promote and suppress chromosomal translocations in lymphocytes|
M Gostissa, FW Alt, R Chiarle
Annual review of immunology 29, 319-350, 2011
|Functional validation of the anaplastic lymphoma kinase signature identifies CEBPB and Bcl2A1 as critical target genes|
R Piva, E Pellegrino, M Mattioli, L Agnelli, L Lombardi, F Boccalatte, ...
The Journal of clinical investigation 116 (12), 3171-3182, 2006
|Ablation of oncogenic ALK is a viable therapeutic approach for anaplastic large-cell lymphomas|
R Piva, R Chiarle, AD Manazza, R Taulli, W Simmons, C Ambrogio, ...
Blood 107 (2), 689-697, 2006
|New and old functions of STAT3: a pivitol target for individualized treatment of cancer|
G Inghirami, R Chiarle, WJ Simmons, R Piva, K Schlessinger, DE Levy
Cell cycle 4 (9), 1131-1133, 2005
|An integrated humoral and cellular response is elicited in pancreatic cancer by α‐enolase, a novel pancreatic ductal adenocarcinoma‐associated antigen|
P Cappello, B Tomaino, R Chiarle, P Ceruti, A Novarino, C Castagnoli, ...
International Journal of Cancer 125 (3), 639-648, 2009