Emad H.M. Hassanein

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Fares E.M. AliPhD, Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar universityVerified email at Azhar.edu.eg
Ayman Moawad MahmoudFaculty of Science, Beni-Suef University, Egypt.Verified email at science.bsu.edu.eg
Ahmed SayedAssistant Professor at Assuit UniversityVerified email at aun.edu.eg
Wafaa R. Mohamedlecturer of pharmacology and toxicology, Faculty of pharmacy, Beni Suef UniversityVerified email at pharm.bsu.edu.eg
Eman K. RashwanAssistant professor of PhysiologyVerified email at ju.edu.sa
Ramadan HemeidaHead of Pharamacology&Toxicolgy Department Deraya UniverstyVerified email at deraya.edu.eg
Abdelgawad ShalkamiAssociate Professor of pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, AssiutVerified email at azhar.edu.eg
Tarek Hamdy Abd-ElhamidLecturer, Histology Department, Faculty of Medicine, Assiut UniversityVerified email at aun.edu.eg
Emadeldin M. KamelFaculty of Science, Beni Suef UniversityVerified email at science.bsu.edu.eg
Islam M. IbrahimPharmacology and toxicology master student at Beni suef universityVerified email at azhar.edu.eg
Ahmed M. AtwaDepartment of Pharmacology & Toxicology, Egyptian Russian UniversityVerified email at eru.edu.eg
Reem alruhaimi,Assistant professor of Physiology Biology Department, Faculty of Science, Princess Nourah bintVerified email at pnu.edu.sa
Dr. Amany MahmoudAssistant professor of Anatomy, UCM, Qassim UniversityVerified email at ucm.edu.sa
Marwa. A. Ahmedlecturer of pharmacology, faculty of medicine, assiut universityVerified email at aun.edu.eg
Esam Omar KamelAssociate professorVerified email at azhar.edu.eg
Shimaa H SalemAssistant Lecturer of Microbiology, Assiut UniversityVerified email at aun.edu.eg
Khaled R. A. AbdellatifIbn Sina National College for Medical Studies, Jeddah, Faculty of Pharmacy Beni-Suef UniversityVerified email at pharm.bsu.edu.eg
Ali H El-BahrawyInstructor, Department of Clinical Pharmacy, College of Pharmacy, Al-Azhar UniversityVerified email at azhar.edu.eg
Hany H ArabProfessor of Biochemistry and Molecular Biology, College of Pharmacy, Taif UniversityVerified email at tu.edu.sa
Maha M Abdel-FattahAssociate Professor of pharmacology and Toxicology Faculty of pharmacy, Beni seuf univeristyVerified email at pharm.bsu.edu.eg

Emad H.M. Hassanein

Lecturer of Pharmacology & Toxicology - Faculty of Pharmacy Al-Azhar University- Assiut branch

Verified email at azhar.edu.eg

Molecular Pharmacology Hepatic Diseases Renal Diseases Cancer Research Drug Discovery


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Coumarins as modulators of the Keap1/Nrf2/ARE signaling pathway EHM Hassanein, AM Sayed, OE Hussein, AM Mahmoud Oxidative Medicine and Cellular Longevity 2020, 2020	154	2020
The impact of Keap1/Nrf2, P38MAPK/NF-κB and Bax/Bcl2/caspase-3 signaling pathways in the protective effects of berberine against methotrexate-induced nephrotoxicity EHM Hassanein, AGS Shalkami, MM Khalaf, WR Mohamed, ... Biomedicine & Pharmacotherapy 109, 47-56, 2019	89	2019
Renoprotective effects of umbelliferone on methotrexate-induced renal injury through regulation of Nrf-2/Keap-1, P38MAPK/NF-κB, and apoptosis signaling pathways EHM Hassanein, WR Mohamed, AGS Shalkami, MM Khalaf, ... Food and chemical toxicology 116, 152-160, 2018	60	2018
New 1, 2, 4-triazole/pyrazole hybrids linked to oxime moiety as nitric oxide donor celecoxib analogs: Synthesis, cyclooxygenase inhibition anti-inflammatory, ulcerogenicity … WAA Fadaly, YAMM Elshaier, EHM Hassanein, KRA Abdellatif Bioorganic Chemistry 98, 103752, 2020	59	2020
Coenzyme Q10 protects hepatocytes from ischemia reperfusion-induced apoptosis and oxidative stress via regulation of Bax/Bcl-2/PUMA and Nrf-2/FOXO-3/Sirt-1 signaling pathways AR Mahmoud, FEM Ali, TH Abd-Elhamid, EHM Hassanein Tissue and Cell 60, 1-13, 2019	49	2019
Flavonoids-mediated SIRT1 signaling activation in hepatic disorders AM Sayed, EHM Hassanein, SH Salem, OE Hussein, AM Mahmoud Life sciences 259, 118173, 2020	39	2020
Umbelliferone attenuates gentamicin-induced renal toxicity by suppression of TLR-4/NF-κB-p65/NLRP-3 and JAK1/STAT-3 signaling pathways EHM Hassanein, FEM Ali, MR Kozman, OAM Abd El-Ghafar Environmental Science and Pollution Research 28, 11558-11571, 2021	37	2021
Edaravone and acetovanillone upregulate Nrf2 and PI3K/Akt/mTOR signaling and prevent cyclophosphamide cardiotoxicity in rats EHM Hassanein, OAM Abd El-Ghafar, MA Ahmed, AM Sayed, ... Drug Design, Development and Therapy, 5275-5288, 2020	37	2020
Reno-protective effects of ursodeoxycholic acid against gentamicin-induced nephrotoxicity through modulation of NF-κB, eNOS and caspase-3 expressions TH Abd-Elhamid, DA Elgamal, SS Ali, FEM Ali, EHM Hassanein, ... Cell and tissue research 374, 367-387, 2018	37	2018
Rebamipide potentially mitigates methotrexate‐induced nephrotoxicity via inhibition of oxidative stress and inflammation: A molecular and histochemical study RA Elmansy, HS Seleem, AR Mahmoud, EHM Hassanein, FEM Ali The Anatomical Record 304 (3), 647-661, 2021	36	2021
Ursodeoxycholic acid abrogates gentamicin-induced hepatotoxicity in rats: Role of NF-κB-p65/TNF-α, Bax/Bcl-xl/Caspase-3, and eNOS/iNOS pathways FEM Ali, EHM Hassanein, AG Bakr, EAM El-Shoura, DA El-Gamal, ... Life sciences 254, 117760, 2020	34	2020
Nephroprotective effect of umbelliferone against cisplatin‐induced kidney damage is mediated by regulation of NRF2, cytoglobin, SIRT1/FOXO‐3, and NF‐ kB‐p65 … FEM Ali, EHM Hassanein, AH El‐Bahrawy, ZMM Omar, EK Rashwan, ... Journal of Biochemical and Molecular Toxicology 35 (5), e22738, 2021	32	2021
Roflumilast protects from cisplatin-induced testicular toxicity in male rats and enhances its cytotoxicity in prostate cancer cell line. Role of NF-κB-p65, cAMP/PKA and Nrf2/HO … BA Abdel-Wahab, IA Walbi, HA Albarqi, FEM Ali, EHM Hassanein Food and Chemical Toxicology 151, 112133, 2021	31	2021
Hepatoprotective effect of rebamipide against methotrexate-induced hepatic intoxication: role of Nrf2/GSK-3β, NF-κβ-p65/JAK1/STAT3, and PUMA/Bax/Bcl-2 signaling pathways BA Abdel-Wahab, FEM Ali, SA Alkahtani, AM Alshabi, MH Mahnashi, ... Immunopharmacology and Immunotoxicology 42 (5), 493-503, 2020	31	2020
Agomelatine prevents gentamicin nephrotoxicity by attenuating oxidative stress and TLR-4 signaling, and upregulating PPARγ and SIRT1 AM Mahmoud, OAM Abd El-Ghafar, MA Alzoghaibi, EHM Hassanein Life Sciences 278, 119600, 2021	30	2021
Targeting KEAP1/Nrf2, AKT, and PPAR-γ signals as a potential protective mechanism of diosmin against gentamicin-induced nephrotoxicity FEM Ali, AM Sayed, AH El-Bahrawy, ZMM Omar, EHM Hassanein Life Sciences 275, 119349, 2021	30	2021
Perindopril Ameliorates Hepatic Ischemia Reperfusion Injury Via Regulation of NF‐κB‐p65/TLR‐4, JAK1/STAT‐3, Nrf‐2, and PI3K/Akt/mTOR Signaling Pathways EO Kamel, EHM Hassanein, MA Ahmed, FEM Ali The Anatomical Record 303 (7), 1935-1949, 2020	29	2020
Farnesol attenuates oxidative stress and liver injury and modulates fatty acid synthase and acetyl-CoA carboxylase in high cholesterol-fed rats MH Abukhalil, OE Hussein, M Bin-Jumah, SAM Saghir, MO Germoush, ... Environmental Science and Pollution Research 27, 30118-30132, 2020	27	2020
Optimization of pyrazole-based compounds with 1, 2, 4-triazole-3-thiol moiety as selective COX-2 inhibitors cardioprotective drug candidates: Design, synthesis, cyclooxygenase … KRA Abdellatif, EKA Abdelall, HAH Elshemy, JN Philoppes, ... Bioorganic chemistry 114, 105122, 2021	24	2021
Acetovanillone prevents cyclophosphamide‐induced acute lung injury by modulating PI3K/Akt/mTOR and Nrf2 signaling in rats OAM Abd El‐Ghafar, EHM Hassanein, AM Sayed, EK Rashwan, ... Phytotherapy Research 35 (8), 4499-4510, 2021	24	2021

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