Correction of a genetic disease in mouse via use of CRISPR-Cas9 Y Wu, D Liang, Y Wang, M Bai, W Tang, S Bao, Z Yan, D Li, J Li Cell stem cell 13 (6), 659-662, 2013 | 871 | 2013 |
Highly efficient therapeutic gene editing of human hematopoietic stem cells Y Wu, J Zeng, BP Roscoe, P Liu, Q Yao, CR Lazzarotto, K Clement, ... Nature medicine 25 (5), 776-783, 2019 | 430 | 2019 |
An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities JM Gehrke, O Cervantes, MK Clement, Y Wu, J Zeng, DE Bauer, L Pinello, ... Nature biotechnology 36 (10), 977-982, 2018 | 417 | 2018 |
Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells Y Wu, H Zhou, X Fan, Y Zhang, M Zhang, Y Wang, Z Xie, M Bai, Q Yin, ... Cell research 25 (1), 67-79, 2015 | 299 | 2015 |
Therapeutic base editing of human hematopoietic stem cells J Zeng, Y Wu, C Ren, J Bonanno, AH Shen, D Shea, JM Gehrke, ... Nature medicine 26 (4), 535-541, 2020 | 229 | 2020 |
Dual base editor catalyzes both cytosine and adenine base conversions in human cells X Zhang, B Zhu, L Chen, L Xie, W Yu, Y Wang, L Li, S Yin, L Yang, H Hu, ... Nature biotechnology 38 (7), 856-860, 2020 | 205 | 2020 |
Genome editing of HBG1 and HBG2 to induce fetal hemoglobin JY Métais, PA Doerfler, T Mayuranathan, DE Bauer, SC Fowler, MM Hsieh, ... Blood advances 3 (21), 3379-3392, 2019 | 135 | 2019 |
Non-viral, specifically targeted CAR-T cells achieve high safety and efficacy in B-NHL J Zhang, Y Hu, J Yang, W Li, M Zhang, Q Wang, L Zhang, G Wei, Y Tian, ... Nature 609 (7926), 369-374, 2022 | 133 | 2022 |
CRISPR-Cas9-mediated genetic screening in mice with haploid embryonic stem cells carrying a guide RNA library C Zhong, Q Yin, Z Xie, M Bai, R Dong, W Tang, YH Xing, H Zhang, S Yang, ... Cell stem cell 17 (2), 221-232, 2015 | 117 | 2015 |
Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci MC Canver, S Lessard, L Pinello, Y Wu, Y Ilboudo, EN Stern, ... Nature genetics 49 (4), 625-634, 2017 | 112 | 2017 |
Increasing the efficiency and targeting range of cytidine base editors through fusion of a single-stranded DNA-binding protein domain X Zhang, L Chen, B Zhu, L Wang, C Chen, M Hong, Y Huang, H Li, H Han, ... Nature cell biology 22 (6), 740-750, 2020 | 88 | 2020 |
Editing aberrant splice sites efficiently restores β-globin expression in β-thalassemia S Xu, K Luk, Q Yao, AH Shen, J Zeng, Y Wu, HY Luo, C Brendel, L Pinello, ... Blood, The Journal of the American Society of Hematology 133 (21), 2255-2262, 2019 | 75 | 2019 |
CRISPR–Cas9-mediated gene editing of the BCL11A enhancer for pediatric β0/β0 transfusion-dependent β-thalassemia B Fu, J Liao, S Chen, W Li, Q Wang, J Hu, F Yang, S Hsiao, Y Jiang, ... Nature medicine 28 (8), 1573-1580, 2022 | 72 | 2022 |
Arabidopsis PLC 2 is involved in auxin‐modulated reproductive development L Li, Y He, Y Wang, S Zhao, X Chen, T Ye, Y Wu, Y Wu The Plant Journal 84 (3), 504-515, 2015 | 62 | 2015 |
BCL11A enhancer–edited hematopoietic stem cells persist in rhesus monkeys without toxicity S Demirci, J Zeng, Y Wu, N Uchida, AH Shen, D Pellin, J Gamer, ... The Journal of clinical investigation 130 (12), 6677-6687, 2020 | 56 | 2020 |
Parthenogenetic haploid embryonic stem cells efficiently support mouse generation by oocyte injection C Zhong, Z Xie, Q Yin, R Dong, S Yang, Y Wu, L Yang, J Li Cell research 26 (1), 131-134, 2016 | 56 | 2016 |
Directly transforming PCR-amplified DNA fragments into plant cells is a versatile system that facilitates the transient expression assay Y Lu, X Chen, Y Wu, Y Wang, Y He, Y Wu PloS one 8 (2), e57171, 2013 | 52 | 2013 |
CPK3-phosphorylated RhoGDI1 is essential in the development of Arabidopsis seedlings and leaf epidermal cells Y Wu, S Zhao, H Tian, Y He, W Xiong, L Guo, Y Wu Journal of experimental botany 64 (11), 3327-3338, 2013 | 34 | 2013 |
Differentially expressed genes of Tetrahymena thermophila in response to tributyltin (TBT) identified by suppression subtractive hybridization and real time quantitative PCR L Feng, W Miao, Y Wu Aquatic toxicology 81 (1), 99-105, 2007 | 34 | 2007 |
Histone deacetylation promotes mouse neural induction by restricting Nodal-dependent mesendoderm fate P Liu, X Dou, C Liu, L Wang, C Xing, G Peng, J Chen, F Yu, Y Qiao, ... Nature communications 6 (1), 6830, 2015 | 30 | 2015 |