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David Boyer
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Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel
B Li, P Ge, KA Murray, P Sheth, M Zhang, G Nair, MR Sawaya, WS Shin, ...
Nature communications 9 (1), 3609, 2018
5432018
Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks
MP Hughes, MR Sawaya, DR Boyer, L Goldschmidt, JA Rodriguez, ...
Science 359 (6376), 698-701, 2018
4042018
Structure-based inhibitors of tau aggregation
PM Seidler, DR Boyer, JA Rodriguez, MR Sawaya, D Cascio, K Murray, ...
Nature chemistry 10 (2), 170-176, 2018
2762018
Cryo-EM structures of four polymorphic TDP-43 amyloid cores
Q Cao, DR Boyer, MR Sawaya, P Ge, DS Eisenberg
Nature structural & molecular biology 26 (7), 619-627, 2019
2122019
Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation
EL Guenther, Q Cao, H Trinh, J Lu, MR Sawaya, D Cascio, DR Boyer, ...
Nature structural & molecular biology 25 (6), 463-471, 2018
2042018
The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure
DR Boyer, B Li, C Sun, W Fan, K Zhou, MP Hughes, MR Sawaya, L Jiang, ...
Proceedings of the National Academy of Sciences 117 (7), 3592-3602, 2020
1422020
Structures of fibrils formed by α-synuclein hereditary disease mutant H50Q reveal new polymorphs
DR Boyer, B Li, C Sun, W Fan, MR Sawaya, L Jiang, DS Eisenberg
Nature structural & molecular biology 26 (11), 1044-1052, 2019
1422019
Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils
Q Cao, DR Boyer, MR Sawaya, P Ge, DS Eisenberg
Nature structural & molecular biology 27 (7), 653-659, 2020
1072020
Isofunctional enzymes PAD1 and UbiX catalyze formation of a novel cofactor required by ferulic acid decarboxylase and 4-hydroxy-3-polyprenylbenzoic acid decarboxylase
F Lin, KL Ferguson, DR Boyer, XN Lin, ENG Marsh
ACS chemical biology 10 (4), 1137-1144, 2015
1022015
Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2
EL Guenther, P Ge, H Trinh, MR Sawaya, D Cascio, DR Boyer, T Gonen, ...
Nature structural & molecular biology 25 (4), 311-319, 2018
992018
Sub-ångström cryo-EM structure of a prion protofibril reveals a polar clasp
M Gallagher-Jones, C Glynn, DR Boyer, MW Martynowycz, E Hernandez, ...
Nature structural & molecular biology 25 (2), 131-134, 2018
902018
CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid
J Lu, Q Cao, MP Hughes, MR Sawaya, DR Boyer, D Cascio, ...
Nature communications 11 (1), 4090, 2020
842020
Structure-based discovery of small molecules that disaggregate Alzheimer’s disease tissue derived tau fibrils in vitro
PM Seidler, KA Murray, DR Boyer, P Ge, MR Sawaya, CJ Hu, X Cheng, ...
Nature communications 13 (1), 5451, 2022
772022
Structure-based inhibitors halt prion-like seeding by Alzheimer’s disease–and tauopathy–derived brain tissue samples
PM Seidler, DR Boyer, KA Murray, TP Yang, M Bentzel, MR Sawaya, ...
Journal of Biological Chemistry 294 (44), 16451-16464, 2019
592019
Nanoscale mosaicity revealed in peptide microcrystals by scanning electron nanodiffraction
M Gallagher-Jones, C Ophus, KC Bustillo, DR Boyer, O Panova, C Glynn, ...
Communications biology 2 (1), 26, 2019
532019
Structure of amyloid-β (20-34) with Alzheimer’s-associated isomerization at Asp23 reveals a distinct protofilament interface
RA Warmack, DR Boyer, CT Zee, LS Richards, MR Sawaya, D Cascio, ...
Nature communications 10 (1), 3357, 2019
472019
Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores
Q Cao, DR Boyer, MR Sawaya, R Abskharon, L Saelices, BA Nguyen, ...
Nature structural & molecular biology 28 (9), 724-730, 2021
462021
Intrinsic electronic conductivity of individual atomically resolved amyloid crystals reveals micrometer-long hole hopping via tyrosines
C Shipps, HR Kelly, PJ Dahl, SM Yi, D Vu, D Boyer, C Glynn, MR Sawaya, ...
Proceedings of the National Academy of Sciences 118 (2), e2014139118, 2021
442021
Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation
R Abskharon, MR Sawaya, DR Boyer, Q Cao, BA Nguyen, D Cascio, ...
Proceedings of the National Academy of Sciences 119 (15), e2119952119, 2022
402022
Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2
E Tayeb-Fligelman, X Cheng, C Tai, JT Bowler, S Griner, MR Sawaya, ...
BioRxiv, 2021.03. 05.434000, 2021
192021
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