| SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver JD Horton, JL Goldstein, MS Brown The Journal of clinical investigation 109 (9), 1125-1131, 2002 | 5913 | 2002 |
| Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity JD Browning, LS Szczepaniak, R Dobbins, JD Horton, JC Cohen, ... Hepatology 40 (6), 1387-1395, 2004 | 4796 | 2004 |
| Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European … BA Ference, HN Ginsberg, I Graham, KK Ray, CJ Packard, E Bruckert, ... European heart journal 38 (32), 2459-2472, 2017 | 3244 | 2017 |
| Molecular mediators of hepatic steatosis and liver injury JD Browning, JD Horton The Journal of clinical investigation 114 (2), 147-152, 2004 | 2733 | 2004 |
| Human fatty liver disease: old questions and new insights JC Cohen, JD Horton, HH Hobbs Science 332 (6037), 1519-1523, 2011 | 2424 | 2011 |
| Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes JD Horton, NA Shah, JA Warrington, NN Anderson, SW Park, MS Brown, ... Proceedings of the National Academy of Sciences 100 (21), 12027-12032, 2003 | 1618 | 2003 |
| Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European … J Boren, MJ Chapman, RM Krauss, CJ Packard, JF Bentzon, CJ Binder, ... European heart journal 41 (24), 2313-2330, 2020 | 1061 | 2020 |
| Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. H Shimano, JD Horton, RE Hammer, I Shimomura, MS Brown, ... The Journal of clinical investigation 98 (7), 1575-1584, 1996 | 995 | 1996 |
| Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells. H Shimano, JD Horton, I Shimomura, RE Hammer, MS Brown, ... The Journal of clinical investigation 99 (5), 846-854, 1997 | 979 | 1997 |
| Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes I Shimomura, Y Bashmakov, S Ikemoto, JD Horton, MS Brown, ... Proceedings of the National Academy of Sciences 96 (24), 13656-13661, 1999 | 951 | 1999 |
| Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. I Shimomura, H Shimano, JD Horton, JL Goldstein, MS Brown The Journal of clinical investigation 99 (5), 838-845, 1997 | 950 | 1997 |
| Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol L Yu, J Li-Hawkins, RE Hammer, KE Berge, JD Horton, JC Cohen, ... The Journal of clinical investigation 110 (5), 671-680, 2002 | 929 | 2002 |
| Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis K Iizuka, RK Bruick, G Liang, JD Horton, K Uyeda Proceedings of the National Academy of Sciences 101 (19), 7281-7286, 2004 | 911 | 2004 |
| Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases … DW Zhang, TA Lagace, R Garuti, Z Zhao, M McDonald, JD Horton, ... Journal of Biological Chemistry 282 (25), 18602-18612, 2007 | 896 | 2007 |
| Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus I Shimomura, Y Bashmakov, JD Horton Journal of Biological Chemistry 274 (42), 30028-30032, 1999 | 878 | 1999 |
| Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9 S Rashid, DE Curtis, R Garuti, NN Anderson, Y Bashmakov, YK Ho, ... Proceedings of the National Academy of Sciences 102 (15), 5374-5379, 2005 | 875 | 2005 |
| Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2. JD Horton, I Shimomura, MS Brown, RE Hammer, JL Goldstein, ... The Journal of clinical investigation 101 (11), 2331-2339, 1998 | 844 | 1998 |
| Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates M Frank-Kamenetsky, A Grefhorst, NN Anderson, TS Racie, B Bramlage, ... Proceedings of the National Academy of Sciences 105 (33), 11915-11920, 2008 | 801 | 2008 |
| Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and inlivers of parabiotic mice TA Lagace, DE Curtis, R Garuti, MC McNutt, SW Park, HB Prather, ... The Journal of clinical investigation 116 (11), 2995-3005, 2006 | 794 | 2006 |
| Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c G Liang, J Yang, JD Horton, RE Hammer, JL Goldstein, MS Brown Journal of Biological Chemistry 277 (11), 9520-9528, 2002 | 790 | 2002 |
