Lydia N Raines
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Tumor-induced reshuffling of lipid composition on the endoplasmic reticulum membrane sustains macrophage survival and pro-tumorigenic activity
G Di Conza, CH Tsai, H Gallart-Ayala, YR Yu, F Franco, L Zaffalon, X Xie, ...
Nature immunology 22 (11), 1403-1415, 2021
Development of a forward-oriented therapeutic lentiviral vector for hemoglobin disorders
N Uchida, MM Hsieh, L Raines, JJ Haro-Mora, S Demirci, AC Bonifacino, ...
Nature communications 10 (1), 1-14, 2019
Carbohydrate and amino acid metabolism as hallmarks for innate immune cell activation and function
H Zhao, LN Raines, SCC Huang
Cells 9 (3), 562, 2020
PERK is a critical metabolic hub for immunosuppressive function in macrophages
LN Raines, H Zhao, Y Wang, HY Chen, H Gallart-Ayala, PC Hsueh, ...
Nature Immunology 23 (3), 431-445, 2022
Evaluating biological activity of compounds by transcription factor activity profiling
A Medvedev, M Moeser, L Medvedeva, E Martsen, A Granick, L Raines, ...
Science advances 4 (9), eaar4666, 2018
Serum-free erythroid differentiation for efficient genetic modification and high-level adult hemoglobin production
N Uchida, S Demirci, JJ Haro-Mora, A Fujita, LN Raines, MM Hsieh, ...
Molecular Therapy-Methods & Clinical Development 9, 247-256, 2018
Molecular chaperones: Molecular assembly line brings metabolism and immunity in shape
H Zhao, LN Raines, SCC Huang
Metabolites 10 (10), 394, 2020
Total body irradiation must be delivered at high dose for efficient engraftment and tolerance in a rhesus stem cell gene therapy model
N Uchida, RP Weitzel, A Shvygin, LP Skala, L Raines, AC Bonifacino, ...
Molecular Therapy-Methods & Clinical Development 3, 16059, 2016
Intrabone transplantation of CD34+ cells with optimized delivery does not enhance engraftment in a rhesus macaque model
K Stringaris, RF Hoyt Jr, JK Davidson-Moncada, JM Pantin, JF Tisdale, ...
Blood advances 4 (24), 6148-6156, 2020
High-level embryonic globin production with efficient erythroid differentiation from a K562 erythroleukemia cell line
N Uchida, JJ Haro-Mora, S Demirci, A Fujita, L Raines, MM Hsieh, ...
Experimental hematology 62, 7-16. e1, 2018
RNA trans-splicing targeting endogenous β-globin pre-messenger RNA in human erythroid cells
N Uchida, KN Washington, B Mozer, C Platner, J Ballantine, LP Skala, ...
Human gene therapy methods 28 (2), 91-99, 2017
Is glucose the scapegoat for tumor evasion?
LN Raines, SCC Huang
Cancer Cell 39 (7), 907-909, 2021
Ex vivo immunological evaluation of stable mixed chimeric patients after matched related donor allogeneic transplantation in sickle cell disease
LN Raines, MM Hsieh, T Nassehi, CM Drysdale, JF Tisdale, N Uchida
Cytotherapy 21 (12), 1206-1215, 2019
A serum-free method for efficient genetic modification and high-level hemoglobin production in human CD34+ cell-derived erythroid cells
N Uchida, J Haro-Mora, A Fujita, L Raines, A Shvygin, L Skala, M Hsieh, ...
MOLECULAR THERAPY 25 (5), 307-307, 2017
Comprehensive assessment of NR ligand polypharmacology by a multiplex reporter NR assay
A Medvedev, M Moeser, L Medvedeva, E Martsen, A Granick, L Raines, ...
Scientific Reports 12 (1), 1-18, 2022
Intrabone Delivery of CD34+ Cells Using an Optimized Delivery System Does Not Enhance Engraftment in a Rhesus Macaque Model of Hematopoietic Stem Cell Transplantation
K Stringaris, RF Hoyt, J Davidson, J Pantin, JF Tisdale, N Uchida, ...
Blood, The Journal of the American Society of Hematology 132 (Supplement 1 …, 2018
GMP-Compliant Non-Viral CRISPR-Mediated Process Correcting the Sickle Cell Disease (SCD) Mutation in SCD Patient Cd34 (+) Cells Achieves 60% Wild Type Adult Hemoglobin …
L Li, N Uchida, JH Mora, S Demirci, L Raines, C Allen, SS De Ravin, ...
MOLECULAR THERAPY 26 (5), 371-372, 2018
Busulfan Combined with Immunosuppression Allows Efficient Engraftment of Gene-Modified Cells in a Rhesus Macaque Model
N Uchida, L Raines, L Breden, A Ingersoll, AC Bonifacino, AE Krouse, ...
MOLECULAR THERAPY 26 (5), 101-102, 2018
Development of an Evaluation System for Immunological Tolerance In Sickle Cell Disease HSC Transplanted Patients with Stable Mixed Chimerism
LN Raines, MM Hsieh, JF Tisdale, N Uchida
Selective Proliferation of Gene-Modified Human Erythroid Cells with Truncated Erythropoietin Receptors
N Uchida, A Shvygin, L Raines, JJJH Mora, S Demirci, MM Hsieh, ...
Blood 130, 3338, 2017
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