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Michael J. Bradley
Michael J. Bradley
Assoc. Director of Biochemistry & Biophysics, RADD Pharmaceuticals
Verified email at raddpharma.com
Title
Cited by
Cited by
Year
Identification of cation-binding sites on actin that drive polymerization and modulate bending stiffness
H Kang, MJ Bradley, BR McCullough, A Pierre, EE Grintsevich, E Reisler, ...
Proceedings of the National Academy of Sciences 109 (42), 16923-16927, 2012
952012
Insights regarding guanine nucleotide exchange from the structure of a DENN-domain protein complexed with its Rab GTPase substrate
X Wu, MJ Bradley, Y Cai, D Kümmel, EM De La Cruz, FA Barr, ...
Proceedings of the National Academy of Sciences 108 (46), 18672-18677, 2011
932011
Nickel-specific response in the transcriptional regulator, Escherichia coli NikR
S Leitch, MJ Bradley, JL Rowe, PT Chivers, MJ Maroney
Journal of the American Chemical Society 129 (16), 5085-5095, 2007
932007
ATP utilization and RNA conformational rearrangement by DEAD-box proteins
A Henn, MJ Bradley, EM De La Cruz
Annual Review of Biophysics 41, 247-267, 2012
882012
Molecular Dynamics Simulation of the< i> Escherichia coli</i> NikR Protein: Equilibrium Conformational Fluctuations Reveal Interdomain Allosteric Communication Pathways
MJ Bradley, PT Chivers, NA Baker
Journal of Molecular Biology 378 (5), 1155-1173, 2008
872008
Mechanism of Mss116 ATPase reveals functional diversity of DEAD-box proteins
W Cao, MM Coman, S Ding, A Henn, ER Middleton, MJ Bradley, ...
Journal of Molecular Biology 409 (3), 399-414, 2011
732011
Discovery and Characterization of SY-1365, a Selective, Covalent Inhibitor of CDK7Discovery and Characterization of a CDK7 Inhibitor SY-1365
S Hu, JJ Marineau, N Rajagopal, KB Hamman, YJ Choi, DR Schmidt, ...
Cancer research 79 (13), 3479-3491, 2019
722019
Regulation of actin by ion-linked equilibria
H Kang, MJ Bradley, WA Elam, M Enrique
Biophysical journal 105 (12), 2621-2628, 2013
502013
Site-specific cation release drives actin filament severing by vertebrate cofilin
H Kang, MJ Bradley, W Cao, K Zhou, EE Grintsevich, A Michelot, ...
Proceedings of the National Academy of Sciences 111 (50), 17821-17826, 2014
472014
Cations stiffen actin filaments by adhering a key structural element to adjacent subunits
GM Hocky, JL Baker, MJ Bradley, AV Sinitskiy, EM De La Cruz, GA Voth
The Journal of Physical Chemistry B 120 (20), 4558-4567, 2016
352016
Selective inhibition of CDK7 reveals high-confidence targets and new models for TFIIH function in transcription
JK Rimel, ZC Poss, B Erickson, ZL Maas, CC Ebmeier, JL Johnson, ...
Genes & development 34 (21-22), 1452-1473, 2020
322020
Analyzing ATP Utilization by DEAD-Box RNA Helicases Using Kinetic and Equilibrium Methods
MJ Bradley, M Enrique
Methods in Enzymology 511, 29, 2012
222012
Ligand‐induced changes in the conformational stability and flexibility of glutamate dehydrogenase and their role in catalysis and regulation
SA Wacker, MJ Bradley, J Marion, E Bell
Protein Science 19 (10), 1820-1829, 2010
212010
Alteration in the cavity size adjacent to the active site of RB69 DNA polymerase changes its conformational dynamics
S Xia, M Wood, MJ Bradley, M Enrique, WH Konigsberg
Nucleic Acids Research, 2013
132013
Discovery of SY-5609: a selective, noncovalent inhibitor of CDK7
JJ Marineau, KB Hamman, S Hu, S Alnemy, J Mihalich, A Kabro, ...
Journal of Medicinal Chemistry 65 (2), 1458-1480, 2021
102021
Using physicochemical properties of amino acids to induce graphical models of residue couplings
KSMT Hossain, C Bailey-Kellogg, AM Friedman, MJ Bradley, N Baker, ...
Proceedings of the Tenth International Workshop on Data Mining in …, 2011
22011
Surviving a bioscience Ph.D. - Mitigating the hurdles and pitfalls faced by doctoral students
M Bradley
ASBMB Today, 2012
2012
Why pursue a Ph.D. in the biosciences?
MJ Bradley
ASBMB Today, 2011
2011
Computational and experimental investigation of allosteric communication in the transcriptional regulator NikR
MJ Bradley
Washington University in St. Louis, 2009
2009
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Articles 1–19