Philip Beachy
Philip Beachy
Professor of Urology, Developmental Biology, Stanford University
Verified email at
Cited by
Cited by
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
C Chiang, Y Litingtung, E Lee, KE Young, JL Corden, H Westphal, ...
Nature 383 (6599), 407, 1996
The Hedgehog and Wnt signalling pathways in cancer
J Taipale, PA Beachy
nature 411 (6835), 349-354, 2001
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
JK Chen, J Taipale, MK Cooper, PA Beachy
Genes & development 16 (21), 2743-2748, 2002
Cholesterol modification of hedgehog signaling proteins in animal development
JA Porter, KE Young, PA Beachy
Science 274 (5285), 255-259, 1996
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
DM Berman, SS Karhadkar, A Maitra, R Montes de Oca, MR Gerstenblith, ...
Nature 425 (6960), 846-851, 2003
Tissue repair and stem cell renewal in carcinogenesis
PA Beachy, SS Karhadkar, DM Berman
Nature 432 (7015), 324-331, 2004
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
J Taipale, JK Chen, MK Cooper, B Wang, RK Mann, L Milenkovic, ...
Nature 406 (6799), 1005-1009, 2000
Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer
DN Watkins, DM Berman, SG Burkholder, B Wang, PA Beachy, SB Baylin
Nature 422 (6929), 313-317, 2003
Hedgehog signalling in prostate regeneration, neoplasia and metastasis
SS Karhadkar, G Steven Bova, N Abdallah, S Dhara, D Gardner, A Maitra, ...
Nature 431 (7009), 707-712, 2004
Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb
B Wang, JF Fallon, PA Beachy
Cell 100 (4), 423-434, 2000
Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis
H Roelink, JA Porter, C Chiang, Y Tanabe, DT Chang, PA Beachy, ...
Cell 81 (3), 445-455, 1995
Small molecule modulation of Smoothened activity
JK Chen, J Taipale, KE Young, T Maiti, PA Beachy
Proceedings of the National Academy of Sciences 99 (22), 14071-14076, 2002
Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
C Zhao, A Chen, CH Jamieson, M Fereshteh, A Abrahamsson, J Blum, ...
Nature 458 (7239), 776-779, 2009
Teratogen-mediated inhibition of target tissue response to Shh signaling
MK Cooper, JA Porter, KE Young, PA Beachy
Science 280 (5369), 1603-1607, 1998
Medulloblastoma growth inhibition by hedgehog pathway blockade
DM Berman, SS Karhadkar, AR Hallahan, JI Pritchard, CG Eberhart, ...
Science 297 (5586), 1559-1561, 2002
The Hedgehog response network: sensors, switches, and routers
L Lum, PA Beachy
science 304 (5678), 1755-1759, 2004
Patched acts catalytically to suppress the activity of Smoothened
J Taipale, MK Cooper, T Maiti, PA Beachy
Nature 418 (6900), 892-896, 2002
Molecular genetics of the bithorax complex in Drosophila melanogaster
W Bender, M Akam, F Karch, PA Beachy, M Peifer, P Spierer, EB Lewis, ...
Science 221 (4605), 23-29, 1983
Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog
JJ Lee, DP von Kessler, S Parks, PA Beachy
Cell 71 (1), 33-50, 1992
Autoproteolysis in hedgehog Protein Biogenesis
JJ Lee, SC Ekker, DP Von Kessler, JA Porter, BI Sun, PA Beachy
Science 266 (5190), 1528-1537, 1994
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