| Eltrombopag added to standard immunosuppression for aplastic anemia DM Townsley, P Scheinberg, T Winkler, R Desmond, B Dumitriu, O Rios, ... New England Journal of Medicine 376 (16), 1540-1550, 2017 | 500 | 2017 |
| Specific inhibition of bcr-abl gene expression by small interfering RNA M Scherr, K Battmer, T Winkler, O Heidenreich, A Ganser, M Eder Blood, The Journal of the American Society of Hematology 101 (4), 1566-1569, 2003 | 453 | 2003 |
| The BCR/ABL tyrosine kinase induces production of reactive oxygen species in hematopoietic cells M Sattler, S Verma, G Shrikhande, CH Byrne, YB Pride, T Winkler, ... Journal of Biological Chemistry 275 (32), 24273-24278, 2000 | 409 | 2000 |
| Hematopoietic growth factors signal through the formation of reactive oxygen species M Sattler, T Winkler, S Verma, CH Byrne, G Shrikhande, R Salgia, ... Blood, The Journal of the American Society of Hematology 93 (9), 2928-2935, 1999 | 307 | 1999 |
| BCR/ABL directly inhibits expression of SHIP, an SH2-containing polyinositol-5-phosphatase involved in the regulation of hematopoiesis M Sattler, S Verma, CH Byrne, G Shrikhande, T Winkler, PA Algate, ... Molecular and cellular biology 19 (11), 7473-7480, 1999 | 149 | 1999 |
| Mutant isocitrate dehydrogenase 1 inhibitor ivosidenib in combination with azacitidine for newly diagnosed acute myeloid leukemia CD DiNardo, AS Stein, EM Stein, AT Fathi, O Frankfurt, AC Schuh, ... Journal of Clinical Oncology 39 (1), 57, 2021 | 132 | 2021 |
| Path to the clinic: assessment of iPSC-based cell therapies in vivo in a nonhuman primate model SG Hong, T Winkler, C Wu, V Guo, S Pittaluga, A Nicolae, RE Donahue, ... Cell reports 7 (4), 1298-1309, 2014 | 101 | 2014 |
| Treatment optimization and genomic outcomes in refractory severe aplastic anemia treated with eltrombopag T Winkler, X Fan, J Cooper, R Desmond, DJ Young, DM Townsley, ... Blood, The Journal of the American Society of Hematology 133 (24), 2575-2585, 2019 | 99 | 2019 |
| Eltrombopag maintains human hematopoietic stem and progenitor cells under inflammatory conditions mediated by IFN-γ LJ Alvarado, HD Huntsman, H Cheng, DM Townsley, T Winkler, X Feng, ... Blood, The Journal of the American Society of Hematology 133 (19), 2043-2055, 2019 | 96 | 2019 |
| Defective telomere elongation and hematopoiesis from telomerase-mutant aplastic anemia iPSCs T Winkler, SG Hong, JE Decker, MJ Morgan, C Wu, WM Hughes, Y Yang, ... The Journal of clinical investigation 123 (5), 1952-1963, 2013 | 80 | 2013 |
| An AAVS1-targeted minigene platform for correction of iPSCs from all five types of chronic granulomatous disease RK Merling, CL Sweeney, J Chu, A Bodansky, U Choi, DL Priel, ... Molecular Therapy 23 (1), 147-157, 2015 | 78 | 2015 |
| Adaptive NK cells can persist in patients with GATA2 mutation depleted of stem and progenitor cells H Schlums, M Jung, H Han, J Theorell, V Bigley, SCC Chiang, DSJ Allan, ... Blood, The Journal of the American Society of Hematology 129 (14), 1927-1939, 2017 | 74 | 2017 |
| Development of an inducible caspase-9 safety switch for pluripotent stem cell–based therapies C Wu, SG Hong, T Winkler, DM Spencer, A Jares, B Ichwan, A Nicolae, ... Molecular Therapy-Methods & Clinical Development 1, 2014 | 69 | 2014 |
| iPSCs and fibroblast subclones from the same fibroblast population contain comparable levels of sequence variations EM Kwon, JP Connelly, NF Hansen, FX Donovan, T Winkler, BW Davis, ... Proceedings of the National Academy of Sciences 114 (8), 1964-1969, 2017 | 62 | 2017 |
| Assessing the risks of genotoxicity in the therapeutic development of induced pluripotent stem cells SG Hong, CE Dunbar, T Winkler Molecular Therapy 21 (2), 272-281, 2013 | 54 | 2013 |
| Eltrombopag monotherapy can improve hematopoiesis in patients with low to intermediate risk-1 myelodysplastic syndrome A Vicente, BA Patel, F Gutierrez-Rodrigues, EM Groarke, V Giudice, ... Haematologica 105 (12), 2785, 2020 | 51 | 2020 |
| β-Globin-expressing definitive erythroid progenitor cells generated from embryonic and induced pluripotent stem cell-derived sacs A Fujita, N Uchida, JJ Haro-Mora, T Winkler, J Tisdale Stem cells 34 (6), 1541-1552, 2016 | 51 | 2016 |
| Efficient generation of β-globin-expressing erythroid cells using stromal cell-derived induced pluripotent stem cells from patients with sickle cell disease N Uchida, JJ Haro-Mora, A Fujita, DY Lee, T Winkler, MM Hsieh, ... Stem Cells 35 (3), 586-596, 2017 | 47 | 2017 |
| No evidence for clonal selection due to lentiviral integration sites in human induced pluripotent stem cells T Winkler, A Cantilena, JY Métais, X Xu, AD Nguyen, B Borate, ... Stem cells 28 (4), 687-694, 2010 | 46 | 2010 |
| Acquired somatic mutations in PNH reveal long-term maintenance of adaptive NK cells independent of HSPCs MAF Corat, H Schlums, C Wu, J Theorell, DA Espinoza, SE Sellers, ... Blood, The Journal of the American Society of Hematology 129 (14), 1940-1946, 2017 | 39 | 2017 |
Danielle TownsleyMedImmune, Clinical DevelopmentVerified email at medimmune.com
