Michael J Holtzman
Michael J Holtzman
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Bronchial hyperreactivity
HA Boushey, MJ Holtzman, JR Sheller, JA Nadel
American Review of Respiratory Disease 121 (2), 389-413, 1980
Potently neutralizing and protective human antibodies against SARS-CoV-2
SJ Zost, P Gilchuk, JB Case, E Binshtein, RE Chen, JP Nkolola, A Schäfer, ...
Nature 584 (7821), 443-449, 2020
SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function
ES Winkler, AL Bailey, NM Kafai, S Nair, BT McCune, J Yu, JM Fox, ...
Nature immunology 21 (11), 1327-1335, 2020
Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8α+ conventional dendritic cells
BT Edelson, W KC, R Juang, M Kohyama, LA Benoit, PA Klekotka, ...
Journal of Experimental Medicine 207 (4), 823-836, 2010
Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease
EY Kim, JT Battaile, AC Patel, Y You, E Agapov, MH Grayson, LA Benoit, ...
Nature medicine 14 (6), 633-640, 2008
O3-induced change in bronchial reactivity to methacholine and airway inflammation in humans
J Seltzer, BG Bigby, M Stulbarg, MJ Holtzman, JA Nadel, IF Ueki, ...
Journal of Applied Physiology 60 (4), 1321-1326, 1986
Importance of airway inflammation for hyperresponsiveness induced by ozone
MJ Holtzman, LM Fabbri, PM O’Byrne, BD Gold, H Aizawa, EH Walters, ...
American Review of Respiratory Disease 127 (6), 686-690, 1983
A SARS-CoV-2 infection model in mice demonstrates protection by neutralizing antibodies
AO Hassan, JB Case, ES Winkler, LB Thackray, NM Kafai, AL Bailey, ...
Cell 182 (3), 744-753. e4, 2020
A single-dose intranasal ChAd vaccine protects upper and lower respiratory tracts against SARS-CoV-2
AO Hassan, NM Kafai, IP Dmitriev, JM Fox, BK Smith, IB Harvey, RE Chen, ...
Cell 183 (1), 169-184. e13, 2020
Influenza virus receptor specificity and cell tropism in mouse and human airway epithelial cells
A Ibricevic, A Pekosz, MJ Walter, C Newby, JT Battaile, EG Brown, ...
Journal of virology 80 (15), 7469-7480, 2006
The microbial metabolite desaminotyrosine protects from influenza through type I interferon
AL Steed, GP Christophi, GE Kaiko, L Sun, VM Goodwin, U Jain, ...
Science 357 (6350), 498-502, 2017
Predominant generation of 15-lipoxygenase metabolites of arachidonic acid by epithelial cells from human trachea.
JA Hunter, WE Finkbeiner, JA Nadel, EJ Goetzl, MJ Holtzman
Proceedings of the National Academy of Sciences 82 (14), 4633-4637, 1985
Long-term IL-33–producing epithelial progenitor cells in chronic obstructive lung disease
DE Byers, J Alexander-Brett, AC Patel, E Agapov, G Dang-Vu, X Jin, K Wu, ...
The Journal of clinical investigation 123 (9), 3967-3982, 2013
Respiratory syncytial virus nonstructural proteins NS1 and NS2 mediate inhibition of Stat2 expression and alpha/beta interferon responsiveness
MS Lo, RM Brazas, MJ Holtzman
Journal of virology 79 (14), 9315-9319, 2005
CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection
JW Tyner, O Uchida, N Kajiwara, EY Kim, AC Patel, MP O'Sullivan, ...
Nature medicine 11 (11), 1180-1187, 2005
Arachidonic acid metabolism
MJ Holtzman
Am Rev Respir Dis 143, 188-203, 1991
Effect of ozone on bronchial reactivity in atopic and nonatopic subjects
MJ Holtzman, JH Cunningham, JR Sheller, GB Irsigler, JA Nadel, ...
American Review of Respiratory Disease 120 (5), 1059-1067, 1979
Stat1 depends on transcriptional synergy with Sp1 (∗)
DC Look, MR Pelletier, RM Tidwell, WT Roswit, MJ Holtzman
Journal of Biological Chemistry 270 (51), 30264-30267, 1995
Neutrophil depletion inhibits airway hyperresponsiveness induced by ozone exposure
PM O’Byrne, EH Walters, BD Gold, HA Aizawa, LM Fabbri, SE Alpert, ...
American Review of Respiratory Disease 130 (2), 214-219, 1984
Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals
JW Tyner, EY Kim, K Ide, MR Pelletier, WT Roswit, JD Morton, JT Battaile, ...
The Journal of clinical investigation 116 (2), 309-321, 2006
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