| Marked elevation of plasma chitotriosidase activity. A novel hallmark of Gaucher disease. CE Hollak, S van Weely, MH Van Oers, JM Aerts The Journal of clinical investigation 93 (3), 1288-1292, 1994 | 1103 | 1994 |
| Novel oral treatment of Gaucher's disease with N-butyldeoxynojirimycin (OGT 918) to decrease substrate biosynthesis T Cox, R Lachmann, C Hollak, J Aerts, S Van Weely, M Hrebícek, F Platt, ... The Lancet 355 (9214), 1481-1485, 2000 | 947 | 2000 |
| Elevated globotriaosylsphingosine is a hallmark of Fabry disease JM Aerts, JE Groener, S Kuiper, WE Donker-Koopman, A Strijland, ... Proceedings of the National Academy of Sciences 105 (8), 2812-2817, 2008 | 782 | 2008 |
| Identification of a novel acidic mammalian chitinase distinct from chitotriosidase RG Boot, EFC Blommaart, E Swart, K Ghauharali-van der Vlugt, N Bijl, ... Journal of biological chemistry 276 (9), 6770-6778, 2001 | 607 | 2001 |
| Therapeutic goals in the treatment of Gaucher disease GM Pastores, NJ Weinreb, H Aerts, G Andria, TM Cox, M Giralt, ... Seminars in hematology 41, 4-14, 2004 | 551 | 2004 |
| The human chitotriosidase gene: nature of inherited enzyme deficiency RG Boot, GH Renkema, M Verhoek, A Strijland, J Bliek, ... Journal of Biological Chemistry 273 (40), 25680-25685, 1998 | 505 | 1998 |
| Cloning of a cDNA encoding chitotriosidase, a human chitinase produced by macrophages (∗) RG Boot, GH Renkema, A Strijland, AJ van Zonneveld, JMFG Aerts Journal of Biological Chemistry 270 (44), 26252-26256, 1995 | 501 | 1995 |
| Chitotriosidase, a chitinase, and the 39‐kDa human cartilage glycoprotein, a chitin‐binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages GH Renkema, RG Boot, FL Au, WE Donker‐Koopman, A Strijland, ... European Journal of Biochemistry 251 (1‐2), 504-509, 1998 | 480 | 1998 |
| Strong induction of members of the chitinase family of proteins in atherosclerosis: chitotriosidase and human cartilage gp-39 expressed in lesion macrophages RG Boot, TAE van Achterberg, BE van Aken, GH Renkema, MJHM Jacobs, ... Arteriosclerosis, thrombosis, and vascular biology 19 (3), 687-694, 1999 | 441 | 1999 |
| Myelin-laden macrophages are anti-inflammatory, consistent with foam cells in multiple sclerosis LA Boven, M Van Meurs, M Van Zwam, A Wierenga-Wolf, RQ Hintzen, ... Brain 129 (2), 517-526, 2006 | 412 | 2006 |
| Purification and Characterization of Human Chitotriosidase, a Novel Member of the Chitinase Family of Proteins (∗) GH Renkema, RG Boot, AO Muijsers, WE Donker-Koopman, JMFG Aerts Journal of Biological Chemistry 270 (5), 2198-2202, 1995 | 407 | 1995 |
| Marked elevation of the chemokine CCL18/PARC in Gaucher disease: a novel surrogate marker for assessing therapeutic intervention RG Boot, M Verhoek, M De Fost, CEM Hollak, M Maas, B Bleijlevens, ... Blood 103 (1), 33-39, 2004 | 397 | 2004 |
| Characterization of human phagocyte-derived chitotriosidase, a component of innate immunity M van Eijk, CPAA van Roomen, GH Renkema, AP Bussink, L Andrews, ... International immunology 17 (11), 1505-1512, 2005 | 364 | 2005 |
| Glycosphingolipids—nature, function, and pharmacological modulation T Wennekes, RJ van den Berg, RG Boot, GA van der Marel, HS Overkleeft, ... Angewandte Chemie International Edition 48 (47), 8848-8869, 2009 | 351 | 2009 |
| Gaucher cells demonstrate a distinct macrophage phenotype and resemble alternatively activated macrophages LA Boven, M van Meurs, RG Boot, A Mehta, L Boon, JM Aerts, JD Laman American journal of clinical pathology 122 (3), 359-369, 2004 | 343 | 2004 |
| Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity JM Aerts, R Ottenhoff, AS Powlson, A Grefhorst, M Van Eijk, ... Diabetes 56 (5), 1341-1349, 2007 | 340 | 2007 |
| Evolution of mammalian chitinase (-like) members of family 18 glycosyl hydrolases AP Bussink, D Speijer, JMFG Aerts, RG Boot Genetics 177 (2), 959-970, 2007 | 336 | 2007 |
| Enzyme therapy for Fabry disease: neutralizing antibodies toward agalsidase alpha and beta GE Linthorst, CEM Hollak, WE Donker-Koopman, A Strijland, JMFG Aerts Kidney international 66 (4), 1589-1595, 2004 | 315 | 2004 |
| Elevated plasma glucosylsphingosine in Gaucher disease: relation to phenotype, storage cell markers, and therapeutic response N Dekker, L van Dussen, CEM Hollak, H Overkleeft, S Scheij, ... Blood, The Journal of the American Society of Hematology 118 (16), e118-e127, 2011 | 297 | 2011 |
| Structure of human chitotriosidase: implications for specific inhibitor design and function of mammalian chitinase-like lectins F Fusetti, H Von Moeller, D Houston, HJ Rozeboom, BW Dijkstra, RG Boot, ... Journal of Biological Chemistry 277 (28), 25537-25544, 2002 | 296 | 2002 |
