Lipotoxicity in obesity and diabetes-related cardiac dysfunction I Zlobine, K Gopal, JR Ussher Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 2016 | 168 | 2016 |
Increased ketone body oxidation provides additional energy for the failing heart without improving cardiac efficiency KL Ho, L Zhang, C Wagg, R Al Batran, K Gopal, J Levasseur, T Leone, ... Cardiovascular research 115 (11), 1606-1616, 2019 | 146 | 2019 |
Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure GM Uddin, L Zhang, S Shah, A Fukushima, CS Wagg, K Gopal, ... Cardiovascular diabetology 18, 1-12, 2019 | 123 | 2019 |
FoxO1 regulates myocardial glucose oxidation rates via transcriptional control of pyruvate dehydrogenase kinase 4 expression K Gopal, B Saleme, R Al Batran, H Aburasayn, A Eshreif, KL Ho, WK Ma, ... American Journal of Physiology-Heart and Circulatory Physiology 313 (3 …, 2017 | 63 | 2017 |
Inactivation of the glucose-dependent insulinotropic polypeptide receptor improves outcomes following experimental myocardial infarction JR Ussher, JE Campbell, EE Mulvihill, LL Baggio, HE Bates, BA McLean, ... Cell metabolism 27 (2), 450-460. e6, 2018 | 62 | 2018 |
Tissue-specific regulation of p53 by PKM2 is redox dependent and provides a therapeutic target for anthracycline-induced cardiotoxicity B Saleme, V Gurtu, Y Zhang, A Kinnaird, AE Boukouris, K Gopal, ... Science translational medicine 11 (478), eaau8866, 2019 | 60 | 2019 |
The opposing function of STAT3 as an oncoprotein and tumor suppressor is dictated by the expression status of STAT3β in esophageal squamous cell carcinoma HF Zhang, Y Chen, C Wu, ZY Wu, DJ Tweardy, A Alshareef, LD Liao, ... Clinical Cancer Research 22 (3), 691-703, 2016 | 57 | 2016 |
Pimozide alleviates hyperglycemia in diet-induced obesity by inhibiting skeletal muscle ketone oxidation R Al Batran, K Gopal, ME Capozzi, JJ Chahade, B Saleme, ... Cell Metabolism 31 (5), 909-919. e8, 2020 | 47 | 2020 |
Identification and modeling of a drug target for Clostridium perfringens SM101 G Chhabra, P Sharma, A Anant, S Deshmukh, H Kaushik, K Gopal, ... Bioinformation 4 (7), 278, 2010 | 47 | 2010 |
The GLP-1 receptor agonist liraglutide increases myocardial glucose oxidation rates via indirect mechanisms and mitigates experimental diabetic cardiomyopathy M Almutairi, K Gopal, AA Greenwell, A Young, R Gill, H Aburasayn, ... Canadian Journal of Cardiology 37 (1), 140-150, 2021 | 42 | 2021 |
β-Catenin, a Sox2 binding partner, regulates the DNA binding and transcriptional activity of Sox2 in breast cancer cells X Ye, F Wu, C Wu, P Wang, K Jung, K Gopal, Y Ma, L Li, R Lai Cellular signalling 26 (3), 492-501, 2014 | 38 | 2014 |
Oxidative stress induces the acquisition of cancer stem-like phenotype in breast cancer detectable by using a Sox2 regulatory region-2 (SRR2) reporter K Gopal, N Gupta, H Zhang, A Alshareef, H Alqahtani, G Bigras, J Lewis, ... Oncotarget 7 (3), 3111, 2016 | 37 | 2016 |
Hypoxia induces the acquisition of cancer stem-like phenotype via upregulation and activation of signal transducer and activator of transcription-3 (STAT3) in MDA-MB-231, a … H Soleymani Abyaneh, N Gupta, A Alshareef, K Gopal, A Lavasanifar, ... Cancer Microenvironment 11, 141-152, 2018 | 36 | 2018 |
Cardiac-specific deletion of pyruvate dehydrogenase impairs glucose oxidation rates and induces diastolic dysfunction K Gopal, M Almutairi, R Al Batran, F Eaton, M Gandhi, JR Ussher Frontiers in Cardiovascular Medicine 5, 17, 2018 | 33 | 2018 |
DDX17 (P72), a Sox2 binding partner, promotes stem-like features conferred by Sox2 in a small cell population in estrogen receptor-positive breast cancer H Alqahtani, K Gopal, N Gupta, K Jung, A Alshareef, X Ye, F Wu, L Li, ... Cellular signalling 28 (2), 42-50, 2016 | 33 | 2016 |
FoxO1 inhibition alleviates type 2 diabetes-related diastolic dysfunction by increasing myocardial pyruvate dehydrogenase activity K Gopal, R Al Batran, TR Altamimi, AA Greenwell, CT Saed, SAT Dakhili, ... Cell Reports 35 (1), 2021 | 31 | 2021 |
Myocardial energy metabolism in non-ischemic cardiomyopathy AA Greenwell, K Gopal, JR Ussher Frontiers in Physiology 11, 570421, 2020 | 28 | 2020 |
STAT1 is phosphorylated and downregulated by the oncogenic tyrosine kinase NPM-ALK in ALK-positive anaplastic large-cell lymphoma C Wu, O Molavi, H Zhang, N Gupta, A Alshareef, KM Bone, K Gopal, F Wu, ... Blood, The Journal of the American Society of Hematology 126 (3), 336-345, 2015 | 28 | 2015 |
Triple negative breast cancers comprise a highly tumorigenic cell subpopulation detectable by its high responsiveness to a Sox2 regulatory region 2 (SRR2) reporter K Jung, N Gupta, P Wang, JT Lewis, K Gopal, F Wu, X Ye, A Alshareef, ... Oncotarget 6 (12), 10366, 2015 | 27 | 2015 |
Biochemical and functional characterization of UDP-galactose 4-epimerase from Aeromonas hydrophila S Agarwal, K Gopal, T Upadhyaya, A Dixit Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1774 (7), 828-837, 2007 | 25 | 2007 |