| Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel B Li, P Ge, KA Murray, P Sheth, M Zhang, G Nair, MR Sawaya, WS Shin, ... Nature communications 9 (1), 3609, 2018 | 550 | 2018 |
| Structure-based inhibitors of tau aggregation PM Seidler, DR Boyer, JA Rodriguez, MR Sawaya, D Cascio, K Murray, ... Nature chemistry 10 (2), 170-176, 2018 | 279 | 2018 |
| Structure-based inhibitors of amyloid beta core suggest a common interface with tau SL Griner, P Seidler, J Bowler, KA Murray, TP Yang, S Sahay, ... Elife 8, e46924, 2019 | 93 | 2019 |
| Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation WS Shin, J Di, Q Cao, B Li, PM Seidler, KA Murray, G Bitan, L Jiang Alzheimer's research & therapy 11, 1-13, 2019 | 90 | 2019 |
| Structure-based discovery of small molecules that disaggregate Alzheimer’s disease tissue derived tau fibrils in vitro PM Seidler, KA Murray, DR Boyer, P Ge, MR Sawaya, CJ Hu, X Cheng, ... Nature communications 13 (1), 5451, 2022 | 79 | 2022 |
| Structure-based inhibitors halt prion-like seeding by Alzheimer’s disease–and tauopathy–derived brain tissue samples PM Seidler, DR Boyer, KA Murray, TP Yang, M Bentzel, MR Sawaya, ... Journal of Biological Chemistry 294 (44), 16451-16464, 2019 | 61 | 2019 |
| Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design Q Cao, WS Shin, H Chan, CK Vuong, B Dubois, B Li, KA Murray, ... Nature chemistry 10 (12), 1213-1221, 2018 | 60 | 2018 |
| Inhibition of synucleinopathic seeding by rationally designed inhibitors S Sangwan, S Sahay, KA Murray, S Morgan, EL Guenther, L Jiang, ... Elife 9, e46775, 2020 | 56 | 2020 |
| Common fibrillar spines of amyloid-β and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors P Krotee, SL Griner, MR Sawaya, D Cascio, JA Rodriguez, D Shi, ... Journal of Biological Chemistry 293 (8), 2888-2902, 2018 | 56 | 2018 |
| Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores Q Cao, DR Boyer, MR Sawaya, R Abskharon, L Saelices, BA Nguyen, ... Nature structural & molecular biology 28 (9), 724-730, 2021 | 46 | 2021 |
| Electronic structure of [Ni (II) S4] complexes from S K-edge X-ray absorption spectroscopy MS Queen, BD Towey, KA Murray, BS Veldkamp, HJ Byker, RK Szilagyi Coordination Chemistry Reviews 257 (2), 564-578, 2013 | 37 | 2013 |
| De novo designed protein inhibitors of amyloid aggregation and seeding KA Murray, CJ Hu, SL Griner, H Pan, JT Bowler, R Abskharon, ... Proceedings of the National Academy of Sciences 119 (34), e2206240119, 2022 | 33 | 2022 |
| Atomic structures of corkscrew‐forming segments of SOD1 reveal varied oligomer conformations S Sangwan, MR Sawaya, KA Murray, MP Hughes, DS Eisenberg Protein Science 27 (7), 1231-1242, 2018 | 24 | 2018 |
| Toward Functional Type III [Fe]‐Hydrogenase Biomimics for H2 Activation: Insights from Computation KA Murray, MD Wodrich, X Hu, C Corminboeuf Chemistry–A European Journal 21 (10), 3987-3996, 2015 | 23 | 2015 |
| Different amyloid-β self-assemblies have distinct effects on intracellular tau aggregation WS Shin, J Di, KA Murray, C Sun, B Li, G Bitan, L Jiang Frontiers in molecular neuroscience 12, 2019 | 20 | 2019 |
| Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2 E Tayeb-Fligelman, X Cheng, C Tai, JT Bowler, S Griner, MR Sawaya, ... BioRxiv, 2021.03. 05.434000, 2021 | 19 | 2021 |
| Extended β-strands contribute to reversible amyloid formation KA Murray, D Evans, MP Hughes, MR Sawaya, CJ Hu, KN Houk, ... ACS nano 16 (2), 2154-2163, 2022 | 17 | 2022 |
| Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils KA Murray, CJ Hu, H Pan, J Lu, R Abskharon, JT Bowler, GM Rosenberg, ... Proceedings of the National Academy of Sciences 120 (7), e2217835120, 2023 | 16 | 2023 |
| Identifying amyloid-related diseases by mapping mutations in low-complexity protein domains to pathologies KA Murray, MP Hughes, CJ Hu, MR Sawaya, L Salwinski, H Pan, ... Nature structural & molecular biology 29 (6), 529-536, 2022 | 14 | 2022 |
| Structure-based inhibitors of tau aggregation. Nat Chem 10: 170–176 PM Seidler, DR Boyer, JA Rodriguez, MR Sawaya, D Cascio, K Murray, ... | 12 | 2018 |
David S. EisenbergPaul Boyer Professor, HHMI-UCLAVerified email at mbi.ucla.edu
