| Predicting new molecular targets for known drugs MJ Keiser, V Setola, JJ Irwin, C Laggner, AI Abbas, SJ Hufeisen, ... Nature 462 (7270), 175-181, 2009 | 1837 | 2009 |
| A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells M Vedadi, D Barsyte-Lovejoy, F Liu, S Rival-Gervier, A Allali-Hassani, ... Nature chemical biology 7 (8), 566-574, 2011 | 547 | 2011 |
| Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs C Wang, H Wu, T Evron, E Vardy, GW Han, XP Huang, SJ Hufeisen, ... Nature communications 5 (1), 4355, 2014 | 277 | 2014 |
| Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65 XP Huang, J Karpiak, WK Kroeze, H Zhu, X Chen, SS Moy, KA Saddoris, ... Nature 527 (7579), 477-483, 2015 | 257 | 2015 |
| Isolation and pharmacological characterization of omega-grammotoxin SIA, a novel peptide inhibitor of neuronal voltage-sensitive calcium channel responses. RA Lampe, PA Defeo, MD Davison, J Young, JL Herman, RC Spreen, ... Molecular pharmacology 44 (2), 451-460, 1993 | 145 | 1993 |
| Fat cell adenylate cyclase system. Enhanced inhibition by adenosine and GTP in the hypothyroid rat. CC Malbon, PJ Rapiejko, TJ Mangano Journal of Biological Chemistry 260 (4), 2558-2564, 1985 | 100 | 1985 |
| Identification of Human Ether-à-go-go Related Gene Modulators by Three Screening Platforms in an Academic Drug-Discovery Setting XP Huang, T Mangano, S Hufeisen, V Setola, BL Roth Assay and drug development technologies 8 (6), 727-742, 2010 | 86 | 2010 |
| Discovery of a Neuroprotective Chemical, (S)-N-(3-(3,6-Dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine [(−)-P7C3-S243], with Improved … J Naidoo, H De Jesus-Cortes, P Huntington, S Estill, LK Morlock, ... Journal of medicinal chemistry 57 (9), 3746-3754, 2014 | 76 | 2014 |
| Improvement of pharmacological properties of irreversible thyroid receptor coactivator binding inhibitors JY Hwang, LA Arnold, F Zhu, A Kosinski, TJ Mangano, V Setola, BL Roth, ... Journal of medicinal chemistry 52 (13), 3892-3901, 2009 | 66 | 2009 |
| Inhibition of K+-evoked [3H] D-aspartate release and neuronal calcium influx by verapamil, diltiazem and dextromethorphan: evidence for non-L/non-N voltage-sensitive calcium … TJ Mangano, J Patel, AI Salama, RA Keith European journal of pharmacology 192 (1), 9-17, 1991 | 59 | 1991 |
| Heart contains two substrates (Mr= 40,000 and 41,000) for pertussis toxin-catalyzed ADP-ribosylation that co-purify with Ns CC Malbon, TJ Mangano, DC Watkins Biochemical and biophysical research communications 128 (2), 809-815, 1985 | 58 | 1985 |
| Characterization of the effects of omega-conotoxin GVIA on the responses of voltage-sensitive calcium channels. RA Keith, TJ Mangano, MA Pacheco, AI Salama Journal of Autonomic Pharmacology 9 (4), 243-252, 1989 | 55 | 1989 |
| Pharmacologic rescue of motor and sensory function by the neuroprotective compound P7C3 following neonatal nerve injury SWP Kemp, M Szynkaruk, KN Stanoulis, MD Wood, EH Liu, MP Willand, ... Neuroscience 284, 202-216, 2015 | 49 | 2015 |
| Structure-based discovery of new antagonist and biased agonist chemotypes for the kappa opioid receptor Z Zheng, XP Huang, TJ Mangano, R Zou, X Chen, SA Zaidi, BL Roth, ... Journal of medicinal chemistry 60 (7), 3070-3081, 2017 | 45 | 2017 |
| HA-966 acts at a modulatory glycine site to inhibit N-methyl-D-aspartate-evoked neurotransmitter release RA Keith, TJ Mangano, BA Meiners, RJ Stumpo, AB Klika, J Patel, ... European journal of pharmacology 166 (3), 393-400, 1989 | 45 | 1989 |
| Effects of stimulus intensity on the inhibition by ω-conotoxin GVIA and neomycin of K+-evoked [3H] norepinephrine release from hippocampal brain slices and synaptosomal calcium … RA Keith, MB Horn, TM Piser, TJ Mangano Biochemical pharmacology 45 (1), 165-171, 1993 | 27 | 1993 |
| 6,7‐Dinitroquinoxaline‐2,3‐Dione Blocks the Cytotoxicity of N‐Methyl‐D‐Aspartate and Kainate, but Not Quisqualate, in Cortical Cultures J Patel, WC Zinkand, AB Klika, TJ Mangano, RA Keith, AI Salama Journal of neurochemistry 55 (1), 114-121, 1990 | 27 | 1990 |
| Stereoselectivity for the (R)‐Enantiomer of HA‐966 (l‐Hydroxy‐3‐Aminopyrrolidone‐2) at the Glycine Site of the N‐Methyl‐d‐Aspartate Receptor Complex LM Pullan, M Britt, MJ Chapdelaine, RA Keith, D LaMonte, TJ Mangano, ... Journal of neurochemistry 55 (4), 1346-1351, 1990 | 26 | 1990 |
| Actions of neomycin on neuronal L-, N-, and non-L/non-N-type voltage-sensitive calcium channel responses RA Keith, TJ Mangano, PA DeFeo, MB Horn, AI Salama Journal of Molecular Neuroscience 3, 147-154, 1992 | 25 | 1992 |
| Structure-Based Design of a Chemical Probe Set for the 5-HT5A Serotonin Receptor A Levit Kaplan, RT Strachan, JM Braz, V Craik, S Slocum, T Mangano, ... Journal of medicinal chemistry 65 (5), 4201-4217, 2022 | 22 | 2022 |
BL RothDepartment of Pharmacology, University of North Carolina Medical SchoolVerified email at med.unc.edu
