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Tina Nassehi
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BCL11A enhancer–edited hematopoietic stem cells persist in rhesus monkeys without toxicity
S Demirci, J Zeng, Y Wu, N Uchida, AH Shen, D Pellin, J Gamer, ...
The Journal of clinical investigation 130 (12), 6677-6687, 2020
332020
High-efficiency lentiviral transduction of human CD34+ cells in high-density culture with poloxamer and prostaglandin E2
N Uchida, T Nassehi, CM Drysdale, J Gamer, M Yapundich, S Demirci, ...
Molecular Therapy-Methods & Clinical Development 13, 187-196, 2019
322019
Busulfan combined with immunosuppression allows efficient engraftment of gene-modified cells in a rhesus macaque model
N Uchida, T Nassehi, CM Drysdale, J Gamer, M Yapundich, ...
Molecular Therapy 27 (9), 1586-1596, 2019
212019
Cas9 protein delivery non-integrating lentiviral vectors for gene correction in sickle cell disease
N Uchida, CM Drysdale, T Nassehi, J Gamer, M Yapundich, J DiNicola, ...
Molecular Therapy-Methods & Clinical Development 21, 121-132, 2021
142021
βT87Q-globin gene therapy reduces sickle hemoglobin production, allowing for ex vivo anti-sickling activity in human erythroid cells
S Demirci, B Gudmundsdottir, Q Li, JJ Haro-Mora, T Nassehi, C Drysdale, ...
Molecular Therapy-Methods & Clinical Development 17, 912-921, 2020
132020
Hematopoietic Stem Cell-Targeted Gene-Addition and Gene-Editing Strategies for β-hemoglobinopathies
CM Drysdale, T Nassehi, J Gamer, M Yapundich, JF Tisdale, N Uchida
Cell Stem Cell 28 (2), 191-208, 2021
112021
Low-dose busulfan reduces human CD34+ cell doses required for engraftment in c-kit mutant immunodeficient mice
A Leonard, M Yapundich, T Nassehi, J Gamer, CM Drysdale, ...
Molecular Therapy-Methods & Clinical Development 15, 430-437, 2019
112019
Preclinical evaluation for engraftment of CD34+ cells gene-edited at the sickle cell disease locus in xenograft mouse and non-human primate models
N Uchida, L Li, T Nassehi, CM Drysdale, M Yapundich, J Gamer, ...
Cell Reports Medicine 2 (4), 100247, 2021
62021
Durable and robust fetal globin induction without Anemia in rhesus monkeys following autologous hematopoietic stem cell transplant with BCL11A Erythroid enhancer editing
S Demirci, J Zeng, Y Wu, N Uchida, J Gamer, M Yapundich, C Drysdale, ...
Blood 134, 4632, 2019
42019
Sustained fetal hemoglobin induction in vivo is achieved by BCL11A interference and coexpressed truncated erythropoietin receptor
N Uchida, F Ferrara, CM Drysdale, M Yapundich, J Gamer, T Nassehi, ...
Science Translational Medicine 13 (591), eabb0411, 2021
32021
Ex vivo immunological evaluation of stable mixed chimeric patients after matched related donor allogeneic transplantation in sickle cell disease
LN Raines, MM Hsieh, T Nassehi, CM Drysdale, JF Tisdale, N Uchida
Cytotherapy 21 (12), 1206-1215, 2019
22019
Truncated erythropoietin receptors confer an in vivo selective advantage in gene-modified erythroid cells expressing fetal hemoglobin due to bcl11a interference
N Uchida, C Drysdale, M Yapundich, J Gamer, T Nassehi, M Wielgosz, ...
Blood 134, 2063, 2019
22019
Preclinical evaluation for engraftment of gene-edited CD34+ cells with a sickle cell disease mutation in a rhesus transplantation model
N Uchida, L Li, T Nassehi, M Yapundich, J Gamer, C Drysdale, ...
Blood 134, 609, 2019
22019
Fetal hemoglobin and F-cell variance in mobilized CD34+ cell-transplanted rhesus monkeys
S Demirci, JJH Mora, M Yapundich, C Drysdale, J Gamer, T Nassehi, ...
Experimental hematology 75, 21-25. e1, 2019
22019
Development of a clinically applicable method for high-efficiency gene correction of plerixafor-mobilized CD34+ cells from patients with sickle cell disease
N Uchida, L Li, JJ Haro-Mora, S Demirci, T Nassehi, J Gamer, C Drysdale, ...
Blood 132, 2191, 2018
22018
Development of Cas9 protein delivery non-integrating lentiviral vectors for gene correction in sickle cell disease
N Uchida, T Nassehi, CM Drysdale, J Gamer, M Yapundich, S Demirci, ...
MOLECULAR THERAPY 28 (4), 395-396, 2020
12020
Durable robust fetal globin induction in rhesus monkeys following BCL11A erythroid enhancer edited autologous hematopoietic stem cell transplant
S Demirci, J Zeng, Y Wu, N Uchida, J Gamer, M Yapundich, C Drysdale, ...
MOLECULAR THERAPY 28 (4), 241-242, 2020
12020
Engraftability of gene-edited sickle cell disease CD34+ cells in xenograft mouse and rhesus transplantation models
N Uchida, L Li, T Nassehi, M Yapundich, J Gamer, C Drysdale, ...
MOLECULAR THERAPY 28 (4), 175-175, 2020
12020
High-Efficiency Lentiviral Transduction of Human CD34+ Cells in High-Density Cell Culture with Poloxamer and Prostaglandin E2 Supplementation
N Uchida, T Nassehi, CM Drysdale, J Gamer, M Yapundich, S Demirci, ...
MOLECULAR THERAPY 27 (4), 325-325, 2019
2019
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