Edze Westra
Edze Westra
Professor of Microbiology, University of Exeter, Biosciences, ESI
Verified email at
Cited by
Cited by
Small CRISPR RNAs guide antiviral defense in prokaryotes
SJJ Brouns, MM Jore, M Lundgren, ER Westra, RJH Slijkhuis, ...
Science 321 (5891), 960-964, 2008
Interference by clustered regularly interspaced short palindromic repeat (CRISPR) RNA is governed by a seed sequence
E Semenova, MM Jore, KA Datsenko, A Semenova, ER Westra, B Wanner, ...
Proceedings of the National Academy of Sciences 108 (25), 10098-10103, 2011
Unravelling the structural and mechanistic basis of CRISPR–Cas systems
J Van Der Oost, ER Westra, RN Jackson, B Wiedenheft
Nature Reviews Microbiology 12 (7), 479-492, 2014
CRISPR immunity relies on the consecutive binding and degradation of negatively supercoiled invader DNA by Cascade and Cas3
ER Westra, PBG van Erp, T KŁnne, SP Wong, RHJ Staals, CLC Seegers, ...
Molecular cell 46 (5), 595-605, 2012
CRISPR-based adaptive and heritable immunity in prokaryotes
J Van der Oost, MM Jore, ER Westra, M Lundgren, SJJ Brouns
Trends in biochemical sciences 34 (8), 401-407, 2009
Structural basis for CRISPR RNA-guided DNA recognition by Cascade
MM Jore, M Lundgren, E Van Duijn, JB Bultema, ER Westra, ...
Nature structural & molecular biology 18 (5), 529-536, 2011
DNA-guided DNA interference by a prokaryotic Argonaute
DC Swarts, MM Jore, ER Westra, Y Zhu, JH Janssen, AP Snijders, ...
Nature 507 (7491), 258-261, 2014
Prophages mediate defense against phage infection through diverse mechanisms
J Bondy-Denomy, J Qian, ER Westra, A Buckling, DS Guttman, ...
The ISME journal 10 (12), 2854-2866, 2016
The CRISPRs, They Are A-Changin': How Prokaryotes Generate Adaptive Immunity
ER Westra, DC Swarts, RHJ Staals, MM Jore, SJJ Brouns, J van der Oost
Annual Reviews of Genetics 46 (1), 311, 2012
CRISPR–Cas systems: beyond adaptive immunity
ER Westra, A Buckling, PC Fineran
Nature Reviews Microbiology 12 (5), 317-326, 2014
H‐NS‐mediated repression of CRISPR‐based immunity in Escherichia coli K12 can be relieved by the transcription activator LeuO
ER Westra, ‹ Pul, N Heidrich, MM Jore, M Lundgren, T Stratmann, ...
Molecular microbiology 77 (6), 1380-1393, 2010
Crystal structure of the CRISPR RNA–guided surveillance complex from Escherichia coli
RN Jackson, SM Golden, PBG van Erp, J Carter, ER Westra, SJJ Brouns, ...
Science 345 (6203), 1473-1479, 2014
Type IE CRISPR-cas systems discriminate target from non-target DNA through base pairing-independent PAM recognition
ER Westra, E Semenova, KA Datsenko, RN Jackson, B Wiedenheft, ...
PLoS genetics 9 (9), e1003742, 2013
Parasite exposure drives selective evolution of constitutive versus inducible defense
ER Westra, S van Houte, S Oyesiku-Blakemore, B Makin, JM Broniewski, ...
Current biology 25 (8), 1043-1049, 2015
Interactions between bacterial and phage communities in natural environments
A Chevallereau, BJ Pons, S van Houte, ER Westra
Nature Reviews Microbiology 20 (1), 49-62, 2022
The diversity-generating benefits of a prokaryotic adaptive immune system
S van Houte, AKE Ekroth, JM Broniewski, H Chabas, B Ashby, ...
Nature 532 (7599), 385-388, 2016
Quorum sensing controls the Pseudomonas aeruginosa CRISPR-Cas adaptive immune system
NM HÝyland-Kroghsbo, J Paczkowski, S Mukherjee, J Broniewski, ...
Proceedings of the National Academy of Sciences 114 (1), 131-135, 2017
Evolutionary ecology of prokaryotic immune mechanisms
S van Houte, A Buckling, ER Westra
Microbiology and Molecular Biology Reviews 80 (3), 745-763, 2016
Clustered regularly interspaced short palindromic repeats (CRISPRs): the hallmark of an ingenious antiviral defense mechanism in prokaryotes
S Al-Attar, ER Westra, J Van Der Oost, SJJ Brouns
Walter de Gruyter 392 (4), 277-289, 2011
Anti-CRISPR phages cooperate to overcome CRISPR-Cas immunity
M Landsberger, S Gandon, S Meaden, C Rollie, A Chevallereau, ...
Cell 174 (4), 908-916. e12, 2018
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