Rebecca M. Sappington, PhD
Rebecca M. Sappington, PhD
Associate Professor and Vice Chair for Research, Depts. Biochemistry and Ophthalmology
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The microbead occlusion model: a paradigm for induced ocular hypertension in rats and mice
RM Sappington, BJ Carlson, SD Crish, DJ Calkins
Investigative ophthalmology & visual science 51 (1), 207-216, 2010
Distal axonopathy with structural persistence in glaucomatous neurodegeneration
SD Crish, RM Sappington, DM Inman, PJ Horner, DJ Calkins
Proceedings of the National Academy of Sciences 107 (11), 5196-5201, 2010
Induced autoimmunity to heat shock proteins elicits glaucomatous loss of retinal ganglion cell neurons via activated T-cell-derived fas-ligand
MB Wax, G Tezel, J Yang, G Peng, RV Patil, N Agarwal, RM Sappington, ...
Journal of Neuroscience 28 (46), 12085-12096, 2008
TRPV1: contribution to retinal ganglion cell apoptosis and increased intracellular Ca2+ with exposure to hydrostatic pressure
RM Sappington, T Sidorova, DJ Long, DJ Calkins
Investigative ophthalmology & visual science 50 (2), 717-728, 2009
Interleukin-6 protects retinal ganglion cells from pressure-induced death
RM Sappington, M Chan, DJ Calkins
Investigative ophthalmology & visual science 47 (7), 2932-2942, 2006
Optic neuropathy due to microbead-induced elevated intraocular pressure in the mouse
H Chen, X Wei, KS Cho, G Chen, R Sappington, DJ Calkins, DF Chen
Investigative ophthalmology & visual science 52 (1), 36-44, 2011
Contribution of TRPV1 to microglia-derived IL-6 and NFκB translocation with elevated hydrostatic pressure
RM Sappington, DJ Calkins
Investigative ophthalmology & visual science 49 (7), 3004-3017, 2008
Quantitative correlation of optic nerve pathology with ocular pressure and corneal thickness in the DBA/2 mouse model of glaucoma
DM Inman, RM Sappington, PJ Horner, DJ Calkins
Investigative ophthalmology & visual science 47 (3), 986-996, 2006
Activation of transient receptor potential vanilloid-1 (TRPV1) influences how retinal ganglion cell neurons respond to pressure-related stress
RM Sappington, T Sidorova, NJ Ward, R Chakravarthy, KW Ho, ...
Channels 9 (2), 102-113, 2015
The nitric oxide-guanylate cyclase pathway and glaucoma
LK Wareham, ES Buys, RM Sappington
Nitric Oxide 77, 75-87, 2018
Retina-on-a-chip: a microfluidic platform for point access signaling studies
KH Dodson, FD Echevarria, D Li, RM Sappington, JF Edd
Biomedical microdevices 17, 1-10, 2015
The challenge of regenerative therapies for the optic nerve in glaucoma
DJ Calkins, M Pekny, ML Cooper, L Benowitz, D Calkins, M Cooper, ...
Experimental eye research 157, 28-33, 2017
Morphometric changes in the rat optic nerve following short-term intermittent elevations in intraocular pressure
KM Joos, C Li, RM Sappington
Investigative ophthalmology & visual science 51 (12), 6431-6440, 2010
Short-term increases in transient receptor potential vanilloid-1 mediate stress-induced enhancement of neuronal excitation
C Weitlauf, NJ Ward, WS Lambert, TN Sidorova, KW Ho, RM Sappington, ...
Journal of Neuroscience 34 (46), 15369-15381, 2014
Astrocyte reactivity: a biomarker for retinal ganglion cell health in retinal neurodegeneration
CR Formichella, SK Abella, SM Sims, HM Cathcart, RM Sappington
Journal of clinical & cellular immunology 5 (1), 2014
Interleukin-6 deficiency attenuates retinal ganglion cell axonopathy and glaucoma-related vision loss
FD Echevarria, CR Formichella, RM Sappington
Frontiers in neuroscience 11, 269614, 2017
Pressure-induced regulation of IL-6 in retinal glial cells: involvement of the ubiquitin/proteasome pathway and NFκB
RM Sappington, DJ Calkins
Investigative ophthalmology & visual science 47 (9), 3860-3869, 2006
The microbead occlusion model of ocular hypertension in mice
DJ Calkins, WS Lambert, CR Formichella, WM McLaughlin, ...
Glaucoma: Methods and Protocols, 23-39, 2018
Optic nerve degeneration in a murine model of juvenile ceroid lipofuscinosis
RM Sappington, DA Pearce, DJ Calkins
Investigative ophthalmology & visual science 44 (9), 3725-3731, 2003
Virus-mediated EpoR76E therapy slows optic nerve axonopathy in experimental glaucoma
WS Bond, J Hines-Beard, YPL GoldenMerry, M Davis, A Farooque, ...
Molecular Therapy 24 (2), 230-239, 2016
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