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Rebecca M. Sappington, PhD
Rebecca M. Sappington, PhD
Associate Professor and Vice Chair for Research, Depts. Biochemistry and Ophthalmology
Verified email at wakehealth.edu
Title
Cited by
Cited by
Year
The microbead occlusion model: a paradigm for induced ocular hypertension in rats and mice
RM Sappington, BJ Carlson, SD Crish, DJ Calkins
Investigative ophthalmology & visual science 51 (1), 207-216, 2010
4112010
Distal axonopathy with structural persistence in glaucomatous neurodegeneration
SD Crish, RM Sappington, DM Inman, PJ Horner, DJ Calkins
Proceedings of the National Academy of Sciences 107 (11), 5196-5201, 2010
3812010
Induced autoimmunity to heat shock proteins elicits glaucomatous loss of retinal ganglion cell neurons via activated T-cell-derived fas-ligand
MB Wax, G Tezel, J Yang, G Peng, RV Patil, N Agarwal, RM Sappington, ...
Journal of Neuroscience 28 (46), 12085-12096, 2008
2392008
TRPV1: contribution to retinal ganglion cell apoptosis and increased intracellular Ca2+ with exposure to hydrostatic pressure
RM Sappington, T Sidorova, DJ Long, DJ Calkins
Investigative ophthalmology & visual science 50 (2), 717-728, 2009
2332009
Interleukin-6 protects retinal ganglion cells from pressure-induced death
RM Sappington, M Chan, DJ Calkins
Investigative ophthalmology & visual science 47 (7), 2932-2942, 2006
1962006
Optic neuropathy due to microbead-induced elevated intraocular pressure in the mouse
H Chen, X Wei, KS Cho, G Chen, R Sappington, DJ Calkins, DF Chen
Investigative ophthalmology & visual science 52 (1), 36-44, 2011
1952011
Contribution of TRPV1 to microglia-derived IL-6 and NFκB translocation with elevated hydrostatic pressure
RM Sappington, DJ Calkins
Investigative ophthalmology & visual science 49 (7), 3004-3017, 2008
1732008
Quantitative correlation of optic nerve pathology with ocular pressure and corneal thickness in the DBA/2 mouse model of glaucoma
DM Inman, RM Sappington, PJ Horner, DJ Calkins
Investigative ophthalmology & visual science 47 (3), 986-996, 2006
1402006
Activation of transient receptor potential vanilloid-1 (TRPV1) influences how retinal ganglion cell neurons respond to pressure-related stress
RM Sappington, T Sidorova, NJ Ward, R Chakravarthy, KW Ho, ...
Channels 9 (2), 102-113, 2015
862015
The nitric oxide-guanylate cyclase pathway and glaucoma
LK Wareham, ES Buys, RM Sappington
Nitric Oxide 77, 75-87, 2018
792018
Retina-on-a-chip: a microfluidic platform for point access signaling studies
KH Dodson, FD Echevarria, D Li, RM Sappington, JF Edd
Biomedical microdevices 17, 1-10, 2015
792015
The challenge of regenerative therapies for the optic nerve in glaucoma
DJ Calkins, M Pekny, ML Cooper, L Benowitz, D Calkins, M Cooper, ...
Experimental eye research 157, 28-33, 2017
632017
Morphometric changes in the rat optic nerve following short-term intermittent elevations in intraocular pressure
KM Joos, C Li, RM Sappington
Investigative ophthalmology & visual science 51 (12), 6431-6440, 2010
612010
Short-term increases in transient receptor potential vanilloid-1 mediate stress-induced enhancement of neuronal excitation
C Weitlauf, NJ Ward, WS Lambert, TN Sidorova, KW Ho, RM Sappington, ...
Journal of Neuroscience 34 (46), 15369-15381, 2014
582014
Astrocyte reactivity: a biomarker for retinal ganglion cell health in retinal neurodegeneration
CR Formichella, SK Abella, SM Sims, HM Cathcart, RM Sappington
Journal of clinical & cellular immunology 5 (1), 2014
582014
Interleukin-6 deficiency attenuates retinal ganglion cell axonopathy and glaucoma-related vision loss
FD Echevarria, CR Formichella, RM Sappington
Frontiers in neuroscience 11, 269614, 2017
552017
Pressure-induced regulation of IL-6 in retinal glial cells: involvement of the ubiquitin/proteasome pathway and NFκB
RM Sappington, DJ Calkins
Investigative ophthalmology & visual science 47 (9), 3860-3869, 2006
552006
The microbead occlusion model of ocular hypertension in mice
DJ Calkins, WS Lambert, CR Formichella, WM McLaughlin, ...
Glaucoma: Methods and Protocols, 23-39, 2018
512018
Optic nerve degeneration in a murine model of juvenile ceroid lipofuscinosis
RM Sappington, DA Pearce, DJ Calkins
Investigative ophthalmology & visual science 44 (9), 3725-3731, 2003
472003
Virus-mediated EpoR76E therapy slows optic nerve axonopathy in experimental glaucoma
WS Bond, J Hines-Beard, YPL GoldenMerry, M Davis, A Farooque, ...
Molecular Therapy 24 (2), 230-239, 2016
452016
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